Simple Steps to Shield Yourself from Mosquito-Borne Threats

By Editorial Team - January 03, 2025

Mosquito-borne diseases pose a significant risk to public health, affecting nearly 80% of the world's population (1). These tiny insects are responsible for spreading viruses and parasites that cause diseases like dengue fever, yellow fever, chikungunya and malaria.

According to the World Health Organization, vector-borne diseases account for more than 17% of all infectious diseases and cause over 700,000 deaths annually (2). The situation has worsened in recent years due to rapid urbanization and population growth, making natural strategies for protection increasingly important.

Mosquito Dangers Lurking in Your Backyard

In the U.S. alone, over 200 types of mosquitoes buzz around, with about 12 species capable of spreading diseases that can make you sick.3 While most mosquitoes are merely a nuisance, it's important to understand the potential threats they carry. The U.S. Centers for Disease Control and Prevention (CDC) warns that you can't tell if a mosquito is infected just by looking at it, which is why protection against all bites is essential.

The most common disease-carrying mosquitoes in the U.S. belong to the Aedes, Culex and Anopheles species.4 These seemingly harmless insects can transmit a variety of viruses and parasites, turning your backyard into a potential health hazard.

It's not just about comfort; it's about safeguarding your health and that of your loved ones. By understanding the risks, you'll be better equipped to take proactive measures to protect yourself and your family from these silent threats.

West Nile Virus and Other Mosquito-Borne Threats

Among the mosquito-borne diseases in the continental U.S., West Nile virus stands out as one of the most prevalent. Transmitted primarily by Culex species mosquitoes, this virus has established itself as a persistent threat across the U.S. What makes West Nile particularly worrisome is its ability to cause severe neurological complications in some cases.

Dengue, chikungunya and Zika viruses have also caused outbreaks in U.S. states and territories, including Florida, Hawaii, Texas, Puerto Rico, the U.S. Virgin Islands and American Samoa. These diseases, primarily spread by Aedes species mosquitoes, cause a range of symptoms from mild fever to severe joint pain.

While less common than some other mosquito-borne diseases, Eastern equine encephalitis5 deserves your attention due to its potential severity. This rare but deadly virus, transmitted primarily by Culiseta melanura mosquitoes, causes inflammation of the brain that can be fatal.

The Insidious Process of Mosquito Disease Transmission

Understanding how mosquitoes transmit diseases can help you appreciate why prevention is so crucial. It's not as simple as a mosquito biting an infected person and then immediately spreading the disease. The process is more complex and insidious. When a female mosquito takes a blood meal from an infected host, it ingests the pathogen — be it a virus or parasite.

But here's the key: the germ must then survive and multiply within the mosquito's body. This process, called the extrinsic incubation period, typically takes two to three weeks. During this time, the pathogen moves from the mosquito's gut to its salivary glands. Only then, when the mosquito bites again, can it transmit the disease through its saliva.

This delay is why mosquito control efforts often focus on eliminating adult mosquitoes that have had time to become infectious. It's also why your vigilance in preventing bites should be constant, as you never know which mosquitoes have completed this incubation period.

Female mosquitoes seek out human blood specifically for reproduction. The proteins and nutrients in your blood are essential for them to produce eggs. These tiny vampires are equipped with a specialized tool called a proboscis — think of it as a natural, ultra-fine hypodermic needle. When a female mosquito lands on your skin, she uses this proboscis to pierce through and navigate until she locates a capillary.

Once she's tapped into your blood supply, she doesn't just take — she gives something in return, though it's far from a fair trade. The mosquito injects her saliva, which contains anticoagulants to keep your blood flowing freely. However, this saliva is also the vehicle for disease transmission, introducing pathogens directly into your bloodstream. As she feeds, your blood fills her abdomen, where it's digested and used to fuel egg production.

Nature's Shield: Plant Oils That Keep Mosquitoes at Bay

Consistent, natural mosquito prevention methods are your best defense against these disease-carrying invaders. A study published in the journal Molecules unveiled the ability of certain plant essential oils to effectively repel mosquitoes, offering a natural alternative to synthetic products.6

Researchers examined oils from five aromatic plants: Lantana camara, Schinus terebinthifolia, Callistemon viminalis, Helichrysum odoratissimum and Hyptis suaveolens. These were tested against three mosquito species known for spreading diseases like dengue, malaria and West Nile virus.

The standout performers? Lantana camara and Schinus terebinthifolia (Brazillian pepper) oils showed exceptional repellent properties, rivaling the effectiveness of DEET, the toxic synthetic repellent.7

Interestingly, different mosquito species reacted differently to the oils, with Culex quinquefasciatus (a carrier of West Nile virus) being the most susceptible to the repellents, followed by Aedes aegypti (dengue vector), while Anopheles gambiae (malaria vector) showed more resistance.

The Science Behind the Scent

You might wonder what makes these plant oils so effective against mosquitoes. The secret lies in their complex chemical composition. For instance, the Lantana camara oil, which showed the highest repellency, contains a mix of compounds including trans-β-caryophyllene, sabinene and 1,8-cineole. These components work together to create a potent mosquito deterrent.

The Schinus terebinthifolia oil, another top performer, boasts a blend of α-pinene, limonene and α-phellandrene. These natural chemicals likely interfere with the mosquitoes' sensory receptors, making it difficult for them to locate their human targets. What's particularly exciting is the longevity of the repellent effect. In some cases, the oils provided protection for up to 180 minutes at higher concentrations.

This extended protection period rivals that of many commercial repellents, suggesting that these natural alternatives are just as practical for everyday use. Moreover, the study found that these oils not only repel adult mosquitoes but also deter females from laying eggs in treated water sources, breaking the mosquito life cycle at multiple points.8

While the study used pure essential oils, it's important to note that these should be properly diluted before application to the skin. You might consider looking for natural repellent products that incorporate these oils, or work with a qualified aromatherapist to create a safe, effective blend.

Beyond personal use, these findings open up exciting possibilities for wider mosquito control strategies, like mosquito traps infused with these natural repellents or public spaces protected by the subtle scent of these plants.

More Traditional Essential Oils as Mosquito Repellents

Another study uncovered the potential of two plants, Citrus macroptera (locally known as Hatkora) and Homalomena aromatica (known as Anchiri), as effective mosquito repellents.9

These plants have been used traditionally by the inhabitants of Mizoram state in India, and now science is backing up their ancestral wisdom. The essential oils extracted from the fruit peel of C. macroptera and the rhizomes of H. aromatica have shown promising results against Aedes aegypti mosquitoes.

The study revealed that H. aromatica oil provided protection for up to 6.16 hours, while C. macroptera oil lasted for 5.16 hours. Compare this to the commonly used DEET, which offers about eight hours of protection.

When these two oils were combined in a 1:1 ratio, they provided protection for 6.33 hours. This natural blend not only repels mosquitoes effectively but also comes with additional benefits, thanks to the presence of limonene, which has antioxidant, anti-inflammatory and neuroprotective properties.

The major components found in both oils are linalool, limonene, terpinen-4-ol and α-terpineol. These compounds interact with the odorant-binding proteins of mosquitoes, essentially confusing their sensory system and making it harder for them to locate you as a potential meal. The researchers conducted molecular docking studies to understand this interaction better.

They found that linalool, which is present in high quantities in H. aromatica oil, had the highest binding energy against the mosquito's odorant-binding protein. This explains why H. aromatica oil showed longer-lasting repellent activity. While limonene had the lowest binding energy, its presence in the oil mixture provides a pleasant scent and additional health benefits, making the blend more appealing for regular use.10

The Power of Environmental Management

One of the most effective ways to shield yourself from mosquito-borne threats is through environmental management. This approach focuses on eliminating mosquito breeding sites and creating an inhospitable environment for these pests. Start by removing standing water around your property, as this is where mosquitoes lay their eggs.

Regularly empty and clean birdbaths, pet water bowls and any containers that collect rainwater. Ensure your gutters are clear and properly draining to prevent water accumulation. Maintain your lawn and garden by keeping grass short and removing excess vegetation where mosquitoes might rest. Consider planting mosquito-repelling plants like citronella grass, marigolds or lavender around your outdoor living areas.

These natural deterrents help create a mosquito-free zone without the use of chemical sprays. You can also install or repair screens on windows and doors to keep mosquitoes out of your home.

In addition, wear light-colored, loose-fitting long sleeves and pants when you're outdoors, especially during dawn and dusk when mosquitoes are most active. These simple clothing choices significantly reduce the amount of exposed skin for mosquitoes to target.

You can also invite nature's mosquito control experts to your yard. Bats are voracious mosquito eaters, capable of consuming up to 1,000 mosquitoes in a single hour.11 Install bat houses in your yard to provide these beneficial creatures with a home. Not only will you be reducing the mosquito population, but you'll also be supporting local wildlife.

Remember, conventional mosquito repellents often contain DEET, a chemical that I've long warned about due to its potential neurotoxic effects. Instead, try natural alternatives like citronella, lemon eucalyptus oil or neem oil. These plant-based repellents are highly effective when used correctly. By embracing these natural methods, you're not only protecting yourself but also contributing to the overall reduction of mosquito populations in your community.

These Natural Remedies May Help With Dengue Recovery

While there are no medications that can cure dengue fever, you can turn to certain foods, herbal remedies and supplements to help naturally strengthen your immune system, increase platelet count and manage symptoms to help facilitate the healing process.

Certain natural remedies have antiviral properties that may help with dengue fever recovery. These include:

1.Carica papaya (Caricaceae) — A 2024 study published in the Asian Plant Research Journal36 says that leaf extracts of this exotic plant, native to Sri Lanka, can "neutralize plasma with the dengue virus, reduce platelet aggregation, and increase the production of the enzyme ALOX12, which promotes platelet production" in dengue patients.

An earlier study, published in the Sri Lankan Journal of Infectious Diseases in 2021,37 found that C. papaya extracts may help inhibit DENV-1 infections, suggesting "the potential of C. papaya leaf extract for future development of antiviral drugs against DENV-1."

2.Euphorbia hirta (Euphorbiaceae) — Also known as "asthma plant," this branched herb only grows up to 70 centimeters high but shows promising potential with its antiviral properties. One analysis published in 202238 notes that clinical investigations of E. hirta among dengue patients ages 30 to 35 years old found that supplementing with this herb helped reduce flu-like symptoms by approximately 70%. According to the study authors:39

"The in vitro analysis of the ethanolic extract of the plant showed remarkable inhibition of plaque formation up to 85% and 34.7% against DENV-1 and DENV-2, respectively."

In the Philippines, where more dengue cases are being reported this year compared to 2023,40 a water decoction made with E. hirta leaves is used to help recover from this condition.41

3.Velvetleaf (Cissampelos pareira) — Native to Sri Lanka, India and the Amazon forest, velvetleaf is a flowering plant that belongs to the Menispermaceae family. A study42 highlights it as one of the botanicals that have shown promise in inhibiting DENV replication, noting that:

"Almost all parts … like aerial parts, roots, and stem barks as well as the whole plants show protective effects against DENV, which are not restricted to DENV-2 or DENV-1 only, but also against type 3 (DENV-3) and type 4 (DENV-4)."

4.Elderberry (Sambucus nigra L.) — Belonging to the family Adoxaceae, elderberry is rich in flavonoids, which are responsible for its antiviral activity. Aside from the extract, elder flowers and leaves were found to have antiviral effects against the DENV-2 strain, at concentrations of 400 micrograms/milliliter (ug/ml).43

5.Garlic (Allium sativum) — Garlic has been widely praised for its antibacterial, antioxidant, anticarcinogenic and other therapeutic properties. One study notes that the organosulfur compounds in this herb, particularly diallyl disulfide (DADS), diallyl sulfide (DAS) and alliin, may significantly inhibit the inflammatory cytokines in DENV-2 infection.44

Nutrition Matters — Boost Your Intake of These Nutrients

Getting enough rest, staying hydrated and consuming a healthy diet are all essential strategies if you’re recovering from a viral disease like dengue fever. During this time, it’s particularly important to get sufficient amounts of healthy nutrients, as some may particularly help speed up the healing process.

A 2021 literature review published in the American Journal of Tropical Medicine and Hygiene45 highlights studies from several countries on how supplementing with certain micronutrients may "offer hypothetical benefits to dengue patients via numerous potential mechanisms, including modulation of the host immune response." Some of the nutrients mentioned include:

Vitamin C — Indian researchers46 found that patients who were given supplemental vitamin C not only had a shorter hospital stay, but also had higher platelet counts than those who did not take the supplement.
Vitamin D — A study from Pakistan47 divided dengue patients into two groups; only those in the first group received vitamin D supplements. The researchers found that ؅those who did not receive the supplement were more likely to develop dengue hemorrhagic fever.
Vitamin E — Researchers from Sri Lanka48 noted that dengue patients who received vitamin E supplements showed "improvements in various clinical and hematological parameters, including significantly higher subsequent platelet counts among patients admitted for thrombocytopenia."
Zinc — A study49 conducted in Thailand found that supplementing with zinc led to a shorter duration of hospitalization among children infected with dengue.

If you consume a healthy, well-balanced diet loaded with whole foods including fruits and vegetables, you’ll have no shortage of these nutrients. For example, kiwi, dragon fruit and papaya are rich in vitamins A, C, E and potassium, all of which may help promote immunity and increase your platelet count naturally.50 As for vitamin D, the best way to boost your levels is to get regular sun exposure as close to solar noon as possible.

Ivermectin for Dengue

PubMed has indexed more than 30 research studies on ivermectin and dengue.

Ivermectin is often recognized – 2nd to penicillin – for having the greatest impact on human health. And its discovery won the Nobel Prize in 2015. Ivermectin has an increasing list of indications due to its antiviral and anti-inflammatory properties, and is included on the WHO’s Model List of Essential Medicines.

Several studies (2020) reported antiviral effects of ivermectin on RNA viruses such as Zika, dengue, yellow fever, West Nile, Hendra, Newcastle, Venezuelan equine encephalitis, chikungunya, Semliki Forest, Sindbis, Avian influenza A, Porcine Reproductive and Respiratory Syndrome, Human immunodeficiency virus type 1, and COVID 19 virus.

Ivermectin inhibits the replication of all 4 DENV serotypes in vitro (Clinical Infectious Diseases 2021).

A 2021 randomized controlled study by Suputtamongkol and colleagues report the findings of a combined phase II and III randomized, double-blind, placebo-controlled trial to test the efficacy of ivermectin as an antiviral drug for dengue.

The trials enrolled a total of 238 patients with dengue—108 in phase 2 and 130 in phase 3 trials. The phase II trial compared 2- and 3-day courses of a once-daily 0.4 mg/kg dose of ivermectin with 3 days of placebo to identify an optimal dosing regimen. The phase III trial followed up on these findings and compared 3-day, once-daily ivermectin dosing with placebo. The primary endpoints were time to virological clearance in the phase II trial and time to fever clearance in the phase III trial. The authors found that, in both trials, time to DENV NS1 antigen clearance was significantly shorter in patients who received doses for 3 days with ivermectin compared with placebo. However, the primary endpoints for both phases II and III trials were not met.

According to the review of this study:

Ivermectin has been shown in experimental models to inhibit both DENV protease as well as translocation of viral proteins into the host nucleus. However, the exact mechanisms have not been defined. Consequently, it is possible that the ivermectin concentrations needed to elicit these inhibitory effects exceeded what can be achieved pharmacokinetically, despite a relative high dose in the phase II and III trials. Thus, while drug repurposing theoretically offers a rapid pathway for discovering new antiviral indications, matching in vitro investigations with drug pharmacokinetics is critical to avoid disappointment during clinical trials.

The possibility that a pharmacokinetic explanation underpinned the current lack of efficacy of ivermectin could be clarified in an ongoing trial of this drug in pediatric patients with dengue (NCT03432442). This trial is exploring an even higher dose (600 μg/kg) of ivermectin as an anti-dengue drug. The final word on repurposing ivermectin as an anti-dengue drug has thus yet to be written.

A 2023 Mexican study by Palacios-Rápalo and colleaques, demonstrated that Ivermectin (IVM) and Atorvastatin (ATV) combination reduced Dengue infection both in vitro and in vivo, suggesting a potential anti-dengue therapy that could be further tested clinically.

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