Povidone Iodine and Coronavirus: A frontline defense against COVID-19 (2022)

Povidone Iodine has been well documented as one of the most effective of all antimicrobials available. Hospitals and medical facilities worldwide use povidone-iodine as a standard of care in infection control, even though it contains very small amounts of Iodine. Povidone Iodine (PVP-1) has been in commercial use since 1955 and is on the World Health Organization’s list of essential medicines.

Source: https://www.who.int/groups/expert-committee-on-selection-and-use-of-essential-medicines/essential-medicines-lists

PVP-1 contains 31,600 ppm of iodine compounds, but it is only I2 that is the biocidal species responsible for its antimicrobial activity. I2 occurs in trace quantities of 2–3 ppm, but even at these levels, it is considered the best at destroying bacteria, viruses, and fungi. All the other aspects of PVP-1 only contribute to its toxicity, staining, and unpleasant taste.

For more than 50 years, PVP-1 has been used as an essential medicine in hospitals and health-care clinics as a scrub for surgeries as well as hand disinfection for surgical personnel. It has been an integral antiseptic as a wound disinfectant.

PVP-1 has also been shown to be highly effective in the treatment of periodontal disease. Jørgen Slots wrote that it is a valuable antiseptic in its treatment of periodontal disease and a variety of other oral infections. His research has shown that it kills all periodontal pathogens in vitro within 15–20 seconds. Slots also says that it exhibits a wide viricidal spectrum, covering both nonenveloped and enveloped viruses, including the periodontopathogenic cytomegalovirus.


David Derry, MD, PhD, author of Iodine: The Forgotten Weapon Against Influenza Viruses, says that after 30 million people were killed by the 1918 Spanish flu pandemic, there was much research funded to discover which agents were effective against influenza viruses. Washing hands with a standard 70% alcohol is effective against most bacteria, but it was shown to have little effect against viruses. Masks used in 1918 showed barely detectable benefits in holding back the influenza viruses. More than 25 years of research has proven that iodine was the most effective agent. Aerosol iodine was found to kill viruses in sprayed mists. Oral preparations were also shown to be effective, along with handwashing using mild iodine solutions. Derry said research showed that iodine incorporated into masks, aerosols, and oral preparations could all help kill influenza viruses. His conclusions state that free iodine (molecular iodine) is the best way to combat an influenza outbreak.


In a study by the Institute for Antiviral Research at Utah State University, it was demonstrated that the COVID-19 virus can be completely inactivated with a 30-second exposure to a 100 ppm molecular iodine (I2) mouthrinse.1 This in vitro study opens the door for further research and the need to review past and current research about the efficacy of I2 as an antimicrobial therapeutic agent. Molecular iodine is the only species of iodine that is antimicrobial.

Source: https://pubchem.ncbi.nlm.nih.gov/patent/US2018360048

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Nobel prize winner Sir Frank Macfarlane Burnet and Joyce D. Stone showed that when mice were exposed to lethal doses of influenza, a control group with iodine rubbed on their snouts survived while the unprotected mice died. They suggested that “it may be worth considering iodine vapor as a practical means of limiting indoor infection during an influenza epidemic.”

Research has continued to show iodine to be effective against viruses. In 1943, Dunham and MacNeal demonstrated that vaccinia virus could be killed with a 3% tincture of iodine. In 1955, Louis Gershenfeld found that tincture of iodine was the most the effective antiseptic found to quickly destroy the poliovirus. He reported that he developed a mouthwash capable of killing the virus using concentrations of free iodine. These landmark studies and others demonstrate iodine’s efficacy as an antiviral.9

Source: Iodine: the forgotten weapon against influenza viruses

Recently, much research has been published on the effects PVP-1 has on the COVID-19 virus and its rapid inactivation upon exposure. Multiple studies have shown that povidone-iodine with its small amount of I2 has quick and effective antiviral qualities and is sufficient to be used as a proactive preventive therapy against COVID-19. It has many uses including hand and skin sanitizing, oral rinsing, throat spraying, gargling, and nasal spraying to inactivate the virus.


  1. doi:10.1007/s40121-018-0200-7
  2. doi:10.1186/s12879-015-1111-9
  3. doi:10.2139/ssrn.3563092

Currently, the most common source of iodine disinfection is PVP-1, but there are limitations of use due to its staining, toxicity, and taste. This new generation of iodine products is now available and has eliminated these negative effects by isolating, stabilizing, and concentrating the bioactive I2. This has enormous implications in the management and treatment of many microbial-sourced diseases. Since I2 has been proven to completely inactivate the COVID-19 virus, it seems prudent that it be used in medical and dental environments.


Most doctors know the need to focus now on early treatment as the most immediate and practical way to reduce hospitalizations and death. However, some doctors and media channels argue that there is very little evidence to support the use of povidone-iodine to prevent or treat COVID-19.

There are 20 published studies supporting povidone-iodine for COVID-19. You can check out the list below (c19pvpi.com).

Povidone-iodine is ranked no. 4 in this COVID-19 early treatment mortality drug league table below. However, this is based on only 1 study.



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