Mebendazole: Hidden Potential and FDA-Approved Hope (2025) - The Wellness Company

Recently, Mel Gibson appeared on The Joe Rogan Experience, where he made a fascinating yet controversial claim — that his friends reportedly overcame cancer using fenbendazole, a veterinary anthelmintic drug. While stories like these spark curiosity, it’s essential to separate anecdotal evidence from established science.

What many people don’t realize is that a closely related drug, mebendazole, is FDA-approved for human use and has been extensively studied for both its antiparasitic and potential anti-cancer effects.

Mebendazole: An FDA-Approved Anthelmintic with Ongoing Cancer Research

Mebendazole was first discovered in 1968 and later marketed as an anthelmintic drug, used to treat a range of parasitical worm infections, including tapeworms, roundworms, and threadworms. It is in the same class as albendazole and others1. However, its potential extends beyond parasites.

As far back as 2002, Mukhopadhyay and colleagues showed that mebendazole was effective in killing lung cancer cell lines. Currently, mebendazole is in Phase I and Phase II clinical trials for pediatric brain cancers (pediatric gliomas) with trials scheduled for completion in April 2025 (2,3).

Mebendazole was pulled from the U.S. market in 2011 for non-safety-related reasons and later reintroduced in 2016 at an astonishingly inflated price. The cost of a standard three-day treatment skyrocketed from $31.92 to $2,656.80. The reason given for the price surge was its outstanding effectiveness and monopoly by a single pharmaceutical company at the time. (Perhaps the 2002 study on lung cancer had something to do with this (4)?

How Mebendazole and Ivermectin Work Together

Mebendazole’s mechanism of action is twofold:
  1. It disrupts microtubules — the structural framework within cells — by binding to tubulin proteins.
  2. It impairs glucose uptake, starving parasites of energy.
Interestingly, these same mechanisms may also make it effective against cancer. By disrupting cell division and depriving cancer cells of their energy supply, mebendazole has demonstrated potential as an anti-cancer agent in laboratory and animal studies.

This is where ivermectin, a Nobel Prize-winning drug, comes into play. Ivermectin enhances mebendazole’s effects by:
  • Blocking multiple pathways cancer cells use to survive
  • Inhibiting metastasis (the spread of cancer)
  • Promoting apoptosis (programmed cell death)
  • Reversing drug resistance, making cancer cells more susceptible to treatment (5,6,7)

Why Mebendazole and not Fenbendazole?

Mebendazole is FDA-approved for human use and has an established safety profile in humans.
Because of this, it has been more extensively tested through ongoing clinical trials
Fenbendazole was found to promote liver tumors in one study.





Why We Make These Medications Available

We believe in providing access to essential medications that have been overlooked or restricted due to monopolization and pricing manipulation — despite their well-documented benefits.

Ivermectin and Mebendazole are powerful, research-backed treatments with established safety profiles, offering promising potential beyond their traditional uses. We make them available because everyone deserves the ability to make informed health decisions without barriers.


Citations:

  1. Centers for Disease Control and Prevention. (2023, January 10). Emerging perspectives on the antiparasitic mebendazole as a repurposed anticancer drug. Retrieved from https://pmc.ncbi.nlm.nih.gov/articles/PMC9862092/
  2. Pantziarka P, Bouche G, Meheus L, Sukhatme V, Sukhatme VP. Repurposing Drugs in Oncology (ReDO)-mebendazole as an anti-cancer agent. Ecancermedicalscience. 2014 Jul 10;8:443. doi: 10.3332/ecancer.2014.443. PMID: 25075217; PMCID: PMC4096024.
  3. Meco D, Attinà G, Mastrangelo S, Navarra P, Ruggiero A. Emerging Perspectives on the Antiparasitic Mebendazole as a Repurposed Drug for the Treatment of Brain Cancers. Int J Mol Sci. 2023 Jan 10;24(2):1334. doi: 10.3390/ijms24021334. PMID: 36674870; PMCID: PMC9862092.
  4. Joo H, Lee J, Maskery BA, Park C, Alpern JD, Phares CR, Weinberg M, Stauffer WM. The Effect of Drug Pricing on Outpatient Payments and Treatment for Three Soil-Transmitted Helminth Infections in the United States, 2010-2017. Am J Trop Med Hyg. 2021 Mar 8;104(5):1851-1857. doi: 10.4269/ajtmh.20-1452. PMID: 33684066; PMCID: PMC8103488.
  5. Guerini AE, Triggiani L, Maddalo M, Bonù ML, Frassine F, Baiguini A, Alghisi A, Tomasini D, Borghetti P, Pasinetti N, Bresciani R, Magrini SM, Buglione M. Mebendazole as a Candidate for Drug Repurposing in Oncology: An Extensive Review of Current Literature. Cancers (Basel). 2019 Aug 31;11(9):1284. doi: 10.3390/cancers11091284. PMID: 31480477; PMCID: PMC6769799.
  6. Sasaki J, Ramesh R, Chada S, Gomyo Y, Roth JA, Mukhopadhyay T. The anthelmintic drug mebendazole induces mitotic arrest and apoptosis by depolymerizing tubulin in non-small cell lung cancer cells. Mol Cancer Ther. 2002 Nov;1(13):1201-9. PMID: 12479701.
  7. Tang M, Hu X, Wang Y, Yao X, Zhang W, Yu C, Cheng F, Li J, Fang Q. Ivermectin, a potential anticancer drug derived from an antiparasitic drug. Pharmacol Res. 2021 Jan;163:105207. doi: 10.1016/j.phrs.2020.105207. Epub 2020 Sep 21. PMID: 32971268; PMCID: PMC7505114.
  8. Shoda, T., Onodera, H., Takeda, M., Uneyama, C., Imazawa, T., Takegawa, K., Yasuhara, K., Watanabe, T., Hirose, M., & Mitsumori, K. (1999). Liver tumor promoting effects of fenbendazole in rats. Toxicologic Pathology, 27(5), 553–562. https://doi.org/10.1177/019262339902700509

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