Prophylaxis for COVID-19 (Prevention Protocols) - FLCCC I-MASK+ and Zelenko 2022

By Dr. Frank Yap, MD -
Prophylaxis is a treatment given to prevent a disease. A prophylactic treatment is a treatment that you take while you are still healthy, in order to prevent getting ill. The main strategy for prevention endorsed by most health authorities is vaccination. Get vaccinated if possible.

If you have not yet been vaccinated, the following prevention protocols have components that have been proven to reduce the risk of getting a COVID infection.



FLCCC-I-MASK+ Prevention Protocol

For prevention, the Front Line COVID-19 Critical Care Working Group (FLCCC) I-MASK+ protocol recommends (updated June 30, 2021):
  • Vitamin D3: 1000–3000 IU/day. Note RDA (Recommended Daily Allowance) is 800–1000 IU/day. The safe upper-dose daily limit is likely < 4000 IU/day. Vitamin D deficiency has been associated with an increased risk of acquiring COVID-19 and from dying from the disease. Vitamin D supplementation may therefore prove to be an effective and cheap intervention to lessen the impact of this disease, particularly in vulnerable populations, i.e. the elderly and obese. (Amazon)
  • Vitamin C: 500 - 1,000 mg BID (twice daily) 
  • Quercetin: 250 mg daily. It is likely that vitamin C and quercetin have synergistic prophylactic benefit. Quercetin should be used with caution in patients with hypothyroidism and TSH levels should be monitored. (Amazon)
  • Melatonin: 6 mg before bedtime (causes drowsiness). (Amazon)
  • Zinc: 30 - 40 mg/day (elemental zinc). Zinc lozenges are preferred. (Amazon)
  • Ivermectin prophylaxis dosage:
    • prevention for high-risk individuals: 0.2 mg/kg per dose (take with or after meals) — one dose today, repeat after 48 hours, then one dose weekly. 
    • Post COVID-19 exposure prevention: 0.2 mg/kg per dose (take with or after meals)  — one dose today, repeat after 48 hours.
High risk Individuals: > 60 years with co-morbidities (hypertension, diabetes, chronic lung disease, chronic kidney disease), obesity, long term care facilities, etc.

Post COVID-19 exposure: To use if a household member is COVID-19 positive, or you have prolonged exposure to a COVID-19 positive patient without wearing a mask.

Precautionary Note: Ivermectin has a number of potentially serious drug-drug interactions. Please check for potential drug interaction at Ivermectin Drug Interactions - Drugs.com. The most important drug interactions occur with cyclosporin, tacrolimus, anti-retroviral drugs, and certain anti-fungal drugs. 

Due to the possible drug interaction between quercetin and ivermectin (may increase ivermectin levels), these drugs should not be taken simultaneously (i.e. should be staggered morning and night). 

Ivermectin is also lipophilic and therefore, bioavailability is maximised on a full stomach; or best to be taken with meal.

Related: List of Doctors that will prescribe Ivermectin

Dr. Zelenko COVID-19 Prophylaxis

Protocol for Low and Moderate Risk Patients:
Protocol for High Risk Patients:
  • Elemental Zinc 25mg once a day 
  • Vitamin D3 5000iu 1 time a day 
  • Hydroxychloroquine (HCQ) 200mg 1 time a day for 5 days, then 1 time a week (Find a Doctor)
  • If HCQ is unavailable, then use the Protocol for Low and Moderate Risk Patients.
Vitamin D For All

Over 100 Scientists, Doctors, & Leading Authorities Call For Increased Vitamin D Use To Combat COVID-19 – “Research shows low vitamin D levels almost certainly promote COVID-19 infections, hospitalizations, and deaths. Given its safety, we call for immediate widespread increased vitamin D intakes.”

They recommend:
* 10,000 IU of Vitamin D3 every day for 3 weeks,
followed by
* 4,000 IU of Vitamin D3 every day thereafter.

Some researchers are simply recommending high levels of vitamin D as a prophylaxis. The list of 40+ studies here show that vitamin D has the effect of reducing risk of infection, of a severe case, and of death from Covid-19. 

Editor's Notes: 
  • Optional: Curcumin: 500 mg twice a day (Ref) (Amazon)
  • Optional:  Betadine Mouth Wash 2 - 3 times a day (Amazon)
  • Vitamin D3: The vitamin D3 dosage in the Zelenko and the 'Vitamin D for All' protocols are relatively higher than the I-MASK+ protocol. If you intend to take it on a long term basis, we suggest that you take the lower dose range.
  • Although ivermectin and hydroxychloroquine are relatively safe drugs, they are still synthetic chemicals that can have side effects. Vitamin D, C, Zinc and Quercetin are nutrients that your body require for optimal health. Nutrients are safer alternatives especially if your risk is low e.g. age below 50 and no other chronic illness. Discuss with your doctor on the benefit vs risk for each treatment.
  • The use of HCQ is highly controversial (Page 16 of FLCCC Alliance – COVID-19 Management Protocol - version May 25, 2021). The best scientific evidence from randomized controlled trials suggests that HCQ has limited/no proven benefit for post exposure prophylaxis, for the early symptomatic phase and in hospitalized patients. Considering, the unique pharmacokinetics of HCQ it is unlikely that HCQ would be of benefit in patients with COVID-19 infection (it takes 5–10 days to achieve adequate plasma and lung concentrations). Finally, it should be recognized that those studies which are widely promoted to support the use of HCQ are severely methodologically flawed. 
  • You still need to follow the advice given by CDC, WHO and your local authority in terms of local guidelines such as mask wearing, social distancing and avoiding crowds. It's better to use multiple strategies in order to defend yourself and your loved ones against this virus, rather than depending only on a single strategy.
Disclaimer: Always see your doctor before taking these supplements. Be aware that most of the 'treatment' dosages are above the recommended dietary allowance (RDA) and therefore such dosages should not be maintained on a long term basis. 

Our aim here isn't to replace your doctors' advice. It is intended as a sharing of knowledge and information. Do take note that supplements are not 100% protective or curative against COVID-19. 

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