Quercetin and NAC for COVID-19 (2024)

By Dr. Frank Yap, MD -

Quercetin, a natural anti-oxidant, anti-inflammatory and anti-blood clot compound contained in abundance in various fruits and vegetables, is a zinc ionophore. The major benefit of taking quercetin with zinc is that the quercetin will push the zinc into the center of the cell where the zinc can stop the virus from reproducing.

Additionally, Quercetin has been shown to be a potent inhibitor of coronaviruses by inhibiting cellular entry as well as inhibiting proinflammatory cytokines. One of the hallmarks of COVID-19 is an imbalanced immune response cascading to cytokine storms and then hyper inflammation which then can lead to acute respiratory distress syndrome (ARDS). 

Quercetin has been shown to inhibit proinflammatory cytokine production as well as inflammation due to its antioxidant properties, amongst others. By inhibiting destructive inflammation and potentially the entire cascade, quercetin may prevent severe damage to the respiratory system amongst other organs (source). 

Red onions, white onions, cranberries, green tea, tomatoes, apples and other vegetables are among the richest sources of dietary quercetin.

As of January 2024, there have been more than 10 published studies of quercetin and COVID-19 (c19quercetin.com). 

Quercetin is also no. 1 in this COVID-19 prevention studies league table:


Quercetin is also part of the popular FLCCC's I-Prevent Protocol and early treatment I-Care Protocol.

Quercetin - Mechanisms of Action

As noted in this study, quercetin was chosen based on the fact that it has antiviral, anti-blood clotting, anti-inflammatory and antioxidant properties, all of which are important in the treatment of SARS-CoV-2 infection. 
Initially, quercetin gained attention because it’s a zinc ionophore, meaning it shuttles zinc — which has well-known antiviral effects — into your cells just like the drug hydroxychloroquine. 

Some proposed the primary reason hydroxychloroquine and quercetin worked was because of this feature. Of course, you also had to take zinc along with either of them. To effectively act as a zinc ionophore, quercetin also needs vitamin C.

Since then, other studies have shown quercetin has other actions that makes it useful against SARS-CoV-2 as well. 

In some studies, quercetin has also been shown to inhibit the release of inflammatory cytokines, which could help alleviate infection-related symptoms and suppress excessive inflammatory responses from occurring.

Its antioxidant effects may also help prevent tissue damage caused by scavenging free radicals, thereby aiding in the recovery process of viral infections.

NAC (N-Acetyl Cysteine) is a precursor to glutathione. It is an antioxidant and increases glutathione levels in the body (Source). NAC has mucolytic activity, so it helps reduce respiratory mucus levels. Laboratory research suggests that NAC might boost immune system function and suppress viral replication. NAC also decreases levels of interleukin-6 and has other anti-inflammatory effects.

As of January 2024, there have been more than 20 published studies of NAC and COVID-19. For the list of studies, check out c19nac. 

NAC inhibits cellular entry and replication of some respiratory viruses, assists in clearing thickened mucous from the airways, suppresses inflammatory signalling, and may help mitigate viral infection-induced cytokine storm (Ref). NAC may also protect against coagulation problems associated with COVID-19, as it has both anticoagulant (source) and thrombolytic effects (source), meaning it may both prevent clots and break up clots that have already formed.

Consider taking around 500 milligrams/day of NAC, as it helps prevent blood clots and is a precursor for your body to produce the important antioxidant glutathione.

Glutathione is also one of the natural blood thinners as it is known to reverse the build-up of plaque and lessen the tendency of abnormal blood clots.

Quercetin and NAC

Quercetin and NAC are both part of the popular FLCCC's early treatment I-Care Protocol for COVID-19.



Body Kitchen Mega NAC and Quercetin


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