Treatment for Long Haulers Syndrome (November 2022)

If you’re still coping with symptoms three months or more after being infected with COVID-19, you’re considered a COVID long-hauler. Post-COVID recovery clinics are being launched nationwide to address this still-growing need. Multiple studies have shown that the SARS-CoV-2 spike protein is a highly toxic and inflammatory protein, capable of causing pathologies in its hosts.

The presence of spike protein has been strongly linked with long COVID. Studies have shown that spike proteins are often present in symptomatic patients, sometimes even months after infections.

As of November 14, 2022, federal data published by the US CDC found that 14.6% (National Estimate) of adults who previously had a COVID-19 infection are currently experiencing symptoms of long COVID.

Of those adults with long COVID, 81% report that their long-term symptoms from the condition have reduced their ability to carry out day-to-day activities. A quarter of the adults with long COVID said that the limitations were “significant.”

The highest rate of daily activity limitations come from the 18-29 age group, while the lowest rate comes from the 40-49 age group.

The survey’s results mean that over 18 million adult Americans are currently experiencing symptoms of long COVID and 15 million have problems performing daily activities because of it.

The data helps to round out the picture of long COVID, a condition the CDC defines as a “wide range of new, returning or ongoing health problems people can experience four or more weeks after first being infected with the virus that causes COVID-19.”

The federal numbers mostly align with estimates from the Brookings Institution that 16 million working age Americans – aged 18 to 65 – are currently experiencing long COVID.

The Brookings report also looked at how long COVID is affecting American lives, finding that up to 4 million working-age adults are out of a job due to long COVID.

However, according to a study published in the Journal of Infectious Diseases in November 2022, the global prevalence of post-COVID syndrome four months after the infection was estimated at 49% of all patients. About 54% of hospitalized patients had long-hauler symptoms; about 34% of non-hospitalized patients had symptoms. A very important point to note here is that a severe disease (hospitalized patients) tend to lead to long COVID as opposed to a mild disease (non hospitalized patients).

Among those who were hospitalized, only 26% fully recovered after five months (R), and nearly half still had symptoms one year later (R). Those who needed mechanical ventilation were 58% less likely to heal fully; obese people were half as likely to recover fully (R). At the two-year mark, 55% of hospitalized patients had at least one COVID-19 symptom, compared to 68% six months after infection. Patients generally had poorer health two years later and still experienced pain, fatigue, problems with sleeping and mental health issues. They went to a doctor more often, had ongoing difficulty exercising, and experienced poor quality of life (R).

As we learn more about post-COVID syndrome, however, the definition has been refined to be more accurate and useful:

• Subacute or ongoing COVID-19 (post-acute COVID-19 syndrome): symptoms continuing beyond four weeks from acute infection, up to 12 weeks.
• Post-acute sequelae of COVID-19 (PASC): symptoms persisting beyond the four weeks after acute infection.
• Post-COVID-19 syndrome (long COVID, long-hauler’s syndrome): chronic ongoing COVID-19 symptoms beyond 12 weeks from acute infection.

With 200-plus symptoms linked to long COVID, treatment starts by pinpointing specific medical conditions and referring patients to the right clinicians. These might be lung specialists, heart specialists or brain rehabilitation experts. Patients need a carefully designed but flexible long haul COVID treatment protocol tailored to their particular symptoms and needs.

Understanding long haulers syndrome and the possible treatments is a vast and dynamic subject. Given the lack of specific treatments of long-haul COVID-19 syndrome, we have compiled and curated relevant and useful information and evidence from various sources about long haulers syndrome. As with most of our articles, the information will evolve as more clinical evidence accumulates. 

In this Article:

• Symptoms of Long Haulers Syndrome
• FLCCC I-Recover Protocol
• Diet and Nutrition
• Intermittent fasting
• Exercise
• Post-Vaccination Long Haulers?
• COVID Spike Protein Treatment for Kids

Symptoms of Long Haulers Syndrome

While the CDC tracks the prevalence of 26 common post-COVID conditions affecting a significant body system, more than 50 long-term effects, particularly fatigue, headache, attention disorders, shortness of breath and hair shedding, are now attributed to long-hauler’s syndrome (R).

Although those hospitalized for COVID-19 are at greater risk of long-hauler’s syndrome, moderate, mild or even asymptomatic illness can also lead to debilitating post-COVID symptoms.

A study published in May 2022, using U.S. health insurance records suggests that over 75% of people with long-hauler’s syndrome were never hospitalized for COVID. After the acute illness was over, nearly 25% of these patients had ongoing respiratory symptoms, chiefly shortness of breath and cough; 17% had fatigue, brain fog, and exhaustion that got worse with physical or mental activity. Abnormal heartbeats and sleep disorders were also common.

An international study showed that fatigue is the most common long-hauler’s syndrome, affecting 80% of all patients. Post-exertional malaise affects 73%, cognitive dysfunction affects 58%, sensorimotor symptoms such as loss of smell affect 56%, headache affects 54%, and memory issues affect 51% (R). A year after infection, common persistent symptoms include fatigue (reported by 82% of patients), brain fog (written by 67%), and headache (reported by 60%) (R).
 

Clinical signs and symptoms can be grouped in the following clusters. The reason for this grouping is to allow organ specific targeted therapy/individualized therapy. 

1. Respiratory: shortness of breath, congestion, persistent cough, etc. 

2. Neurological/psychiatric: brain fog, malaise, tiredness, headaches, migraines, depression, inability to focus/concentrate, altered cognition, insomnia, vertigo, panic attacks, tinnitus, anosmia, phantom smells, parosmia etc. 

3. Musculoskeletal: myalgias, fatigue, weakness, joint pains, inability to exercise, post-exertional malaise, inability to perform normal activities of daily life (ADL’s), muscle mass loss

4. Cardiovascular: Palpitations, arrhythmias, Raynaud like syndrome, hypotension, and tachycardia on exertion. 

5. Autonomic: Postural tachycardia syndrome (POTs), abnormal sweating. 

6. GIT disturbance: Anorexia, diarrhea, bloating, vomiting, nausea, etc. 

7. Dermatologic: Itching, rashes, dermatographia, hair loss.

8. Mucus membranes: Running nose, sneezing, Burning and itchy eyes.

9. Auditory: tinnitus, hearing loss and vertigo. (R, R)

10. Endocrine dysfunction: adrenal gland dysfunction., thyroid dysfunction, estrogen and progesterone dysfunction, testosterone dysfunction.

If you’ve had COVID-19, especially if it was a severe case, be aware that blood clots and heart problems, including heart attack, can occur for 90 days or more. It’s believed that remnants of the virus remain in the nervous system, the lungs, the heart and other organs.

If the symptoms include major shortness of breath, cough with blood in it or pain on one side when you take a deep breath, it could be due to a late pulmonary embolism or a blood clot going to the lungs. Please visit your medical doctor or the nearest 24-hr medical emergency center immediately.

FLCCC I-Recover Protocol for Long Covid

The FLCCC (Front Line COVID-19 Critical Care Alliance) was formed by leading critical care specialists in March 2020, at the beginning of the Coronavirus pandemic, dedicated to developing highly effective treatment protocols to prevent the transmission of COVID-19 and to improve the outcomes for patients ill with the disease.

Though there are many long haulers treatment protocols out there, we consider and recommend the I-Recover for Long Covid protocol as one of the best.

Given the lack of clinical trials of long-haul COVID-19 syndrome, these recommendations are based on the abnormal changes within the body associated with the COVID-19 disease and post viral illnesses along with the collective experience of FLCCC members.

This protocol has also been used to treat post-vaccine inflammatory syndromes with similar success. As with all FLCCC Alliance protocols, the components, doses, and durations will evolve as more clinical data accumulates. 

The I-Recover protocol for long COVID has been updated and below is their latest version (version 3: Sep 6, 2022). Do not confuse this I-Recover protocol for long haul COVID with another I-Recover protocol for post-vaccine syndrome that was launched in May 2022, by FLCCC. One is for post covid long haulers and the other, for post vaccine syndrome.

Treatment must be individualized according to each patient’s presenting symptoms and disease syndromes. It is likely that not all patients will respond equally to the same intervention; a particular intervention may be life-saving for one patient and totally ineffective for another. Early treatment is essential; it is likely that the response to treatment will be attenuated when treatment is delayed. 

First-line treatments (In order of priority; not all required):

• Prednisone: 10–15mg daily for 3 weeks. Taper to 10mg for three days, then 5mg for three days and then stop.
• Ivermectin: 0.2 - 0.3 mg/kg body weight. (R) (Find a Doctor)
• Low dose naltrexone (LDN): Begin with 1 mg daily and increase to 4.5mg as required. May take 2–3 months for full effect.
• Intermittent daily fasting and/or periodic daily fasts: Fasting promotes autophagy, the body’s protective mechanism to remove misfolded, foreign and damaged proteins. It also promotes mitophagy and the release of stem cells. It is likely that promoting autophagy will aid in the removal of the spike protein. NOTE: Hydroxychloroquine inhibits autophagy and should be avoided in patients undergoing intermittent fasting.
• Spermidine and/or Resveratrol: These compounds have been demonstrated to augment autophagy. Wheatgerm, mushrooms, grapefruit, apples and mango are high natural sources of spermidine. A bio-enhanced formulation containing trans-resveratrol from Japanese Knotwood Root appears to have good bio-availability.
• Melatonin: 8mg at night (slow release/extended release preferred) with attention to sleep hygiene. Increase dose from 1mg as tolerated (may cause severe nightmares at high dosages). 
• Vitamin D: The majority of those with post-COVID-19 syndrome continue to have hypovitaminosis D. See tables 1 or 2 for vitamin D supplementation.
• Omega-3 fatty acids: Vascepa, Lovaza or DHA/EPA 4g per day. Omega-3 fatty acids play an important role in the resolution of inflammation by inducing resolvin production. [Ref, Ref] 
• Curcumin (turmeric): 500 mg twice daily. Has anti-inflammatory and immunomodulating properties and has been demonstrated to repolarize macrophages. 
• Aspirin — 81 milligrams a day.

2nd Line Therapies

If symptoms do not improve after 1-2 weeks continue steroids, Omega-3 fatty acids and LDN and add second line therapies as below.

• Fluvoxamine (low dose): 25mg once daily. Stop if the symptoms increase. Caution with the use of other antidepressants and psychiatric drugs. Taper and discontinue once symptoms improve.
• Hydroxychloroquine (HCQ): 200 mg twice daily for 1-2 weeks, then reduce as tolerated to 200 mg daily. HCQ is the preferred second line agent. With long term usage, the dose should be reduced (100 mg or 150 mg daily) in patients weighing less than 61 kg (135 lbs).
• Intravenous Vitamin C: 25 g/week, together with oral Vitamin C 1000 mg (1 gram) 2-3 times daily. Oral Vitamin C is important to provide nutrients for the microbiome. Total daily doses of 8-12 g have been well-tolerated, however chronic high doses have been associated with the development of kidney stones, so the duration of therapy should be limited. Wean IV Vitamin C as tolerated.
• Mitochondrial energy optimizer with pyrroloquinoline quinone (e.g., Life Extension Energy Optimizer or ATP 360®). 
• N-acetyl cysteine (NAC): 600-1500 mg/day.

3rd Line Therapies

• Maraviroc (Pfizer’s CCR5 antagonist): 300mg PO twice a day If 6–8 weeks have elapsed and significant symptoms persist, consider either getting an InCellDx test to assess long hauler index profile prior to initiating or can consider initiating empirically. Note maraviroc can be expensive and it has risk for significant side effects and drug interactions. 
• Non-invasive brain stimulation (NIBS): using transcranial direct current stimulation or transcranial magnetic stimulation. NIBS is painless, extremely safe, and easy to administer. NIBS is offered by many Physical Medicine and Rehabilitation Centers. Patients may also purchase an FDA-approved device for home use.

The options below are from the I-Recover protocol for long haulers version 2: Jan 20, 2022. We have included here for your reference.

Optional adjunctive therapies (in order of priority)

• Nigella Sativa: which like curcumin has anti-inflammatory and immunomodulating properties.
• Atorvastatin: 20–40mg once daily. Caution in patients with Postural Orthostatic Tachycardia Syndrome (POTS); may exacerbate symptoms.
• Kefir, probiotic yogurt and/or Bifidobacterium Probiotics (e.g., Daily Body Restore) together with Prebiotics (e.g. XOS Prebiotic, Bio Nutrition Pre-Biotic) to normalize the microbiome. Prolonged dysbiosis has been reported following COVID-19 infection. (R)
• Behavioral modification, mindfulness therapy and psychological support may help improve survivors’ overall well-being and mental health. 
• Luteolin 100–200mg day or Quercetin 250mg day (or mixed flavonoids). Luteolin and quercetin have broad spectrum anti-inflammatory properties. These natural flavonoids inhibit mast cells, and have been demonstrated to reduce neuroinflammation. [R]
• H1 receptor blockers (for mast cell activation syndrome): Loratadine 10mg daily, or Cetirizine 5–10mg daily, or Fexofenadine 180mg — daily. 
• H2 receptor blockers (for mast cell activation syndrome): Famotidine 20–40mg, or Nizatidine 150mg — twice daily as tolerated. 
• Montelukast: 10mg/day (for mast cell activation syndrome). Caution as may cause depression in some patients. 
• Anti-androgen therapy: Spironolactone 50–100mg twice a day, and Dutasteride 1mg daily. 

Mast cell stabilisers: rupadatadine, quercetin or luteolin.

Republished from: https://covid19criticalcare.com/covid-19-protocols/i-recover-long-covid-treatment/

Be on the Lookout for Blood Clots for 90 Days

If you’ve had COVID-19, especially if it was a severe case, be aware that blood clots and heart problems, including heart attack, can occur for 90 days or more. It’s believed that remnants of the virus remain in the nervous system, the lungs, the heart and other organs.

If the symptoms include major shortness of breath, cough with blood in it or pain on one side when you take a deep breath, it could be due to a late pulmonary embolism or a blood clot going to the lungs. “We’ve seen this on more than one occasion,” Dr Peter McCullough said.

In this case, McCullough recommends a chest CT with contrast and, if a blood clot is found, oral blood thinners for three to six months. McCullough also uses full-dose aspirin — 325 milligrams a day — in almost everyone with long COVID syndrome who doesn’t have a major blood clot, in addition to other medications.

Aside from a CT scan to rule out pulmonary embolism if you’re having symptoms and possibly a D-dimer test, McCullough suggests a high-sensitivity C-reactive protein (CRP) test, which provides a general index of inflammation. Keep in mind, though, as McCullough said:

“This pursuit of a blood clot is very important. I’ve seen multiple cases now where blood clots have been missed … this is now almost a daily occurrence, particularly within the first 90 days after COVID-19. I think after that period of time it becomes progressively less likely.”

Related: Anti Spike Protein Effect of Ivermectin

Diet and Nutrition

No amount of supplements can replace a good diet and similarly, no amount of supplements can reverse a bad diet.

It is believed that eating fruits, vegetables, and getting physical exercise is beneficial to thrombotic status—especially in those who are at risk of thrombotic diseases.

In many countries including the United States, recommendation for an antithrombotic diet and adequate physical exercise have been proposed by health authorities.

“Diet can be a source of inflammation, and whatever we can do to lower [inflammation] will allow the immune system to work better,” says Elizabeth Boham, MD, MS, RD, a functional-medicine physician and medical director at the UltraWellness Center in Lenox, Mass.

She recommends her patients limit their intake of refined carbohydrates and focus on whole foods rich in protein, fiber, healthy fats, and the micronutrients the immune system needs to thrive.

Supporting a good nutrient baseline is also key. “We see a significant amount of nutrient deficiencies and insufficiencies in the United States,” Boham says. Notably, insufficient levels of zinc and selenium are associated with worse outcomes from viral infections. Good sources of zinc include oysters, hemp seeds and pumpkinseeds, beans, nuts, and animal protein; sources of selenium include mushrooms, Brazil nuts, and seafood.

“Make sure you’re getting eight to 12 servings of phytonutrients a day from vegetables, fruits, spices, herbs, and tea,” she advises. Phytonutrients such as EGCG (epigallocatechin gallate, a polyphenol found in green tea) and curcumin (found in turmeric) can decrease inflammation and rebalance the immune system. 

Another key diet related advice is what NOT to eat. Cut down on processed food, sugar, adulterated vegetables oils and trans fats.

Related: 10 Natural Key Supplements for Long Haulers

Nutraceutical Therapy by Mode of Action

Antithrombotic Therapy (Ref)

In general, there are two classes of antithrombotic drugs: anticoagulants and antiplatelet drugs. Anticoagulants act on the clotting cascade and keep it from completion while antiplatelet medicines inhibit the platelets from activating and attaching to each other and the endothelium.

Dr. Jordan Vaughn, internal medicine specialist in Birmingham, Alabama, says it’s key to start antithrombotic treatment in affected patients as early as possible.

“In the acutely ill from COVID-19, it was the sickest that I put on anticoagulation to prevent them from hospitalization. Starting them on DOAC and antiplatelet therapy was the foundation of keeping the hypoxic COVID-19 patient requiring hospitalization,” Dr. Vaughn said.

“After reading and understanding the COVID-19 associated coagulopathy, it was critical to understand this pathophysiology and manage this unique disease state because all of them are hypercoagulable. In acute severe COVID, I would treat patients with antithrombotic therapy and have them come back every few days to see if their symptoms improve.”

“In those that I would start anticoagulation, I started to notice that not only did they get better, but very few of them came back with long-term complications. So it seemed to me that, theoretically, it was like whatever we’re doing differently and treating these patients that are typically sicker was actually improving their symptoms in acute phase and also for the most part prevented the post-acute sequela that often came later in patients that were never acutely severe.”

Dr. Vaughn said he selects some coagulation lab tests to see if his patients were elevated in those factors at all.

“It was after the success of antiplatelet and anticoagulation in the acute treatment of COVID that I started to wonder about utilizing it in post acute sequelae COVID (PASC), and was led by diligent research to the work of Jaco Laubscher, Resia Pretorious, and Doug Kell.”

“It was as if a light bulb went off when I read their work. It profoundly changed how I look at both acute covid, but most importantly long COVID/PASC and their work was instrumental to truly helping suffering patients.”

Whether the cause of blood clots is the virus or vaccine, the symptoms do not differ much because the foundational cause is the spike protein.

Thus, when treating syndromes involving microclotting and local tissue hypoxia, regardless of the source of spike protein, the mess to clean up is the same.

It has been also reported that suitable and closely monitored “triple” anticoagulant therapy leads to the removal of the microclots and also removes symptoms.

It is a dual antiplatelet therapy (DAPT) (Ciopidogrel 75 mg and Aspirin 75 mg) once a day and direct oral anticoagulant (DOAC) (Apixiban 5 mg twice a day). In addition, it is important to include stomach protection with a medicine like a h2 blocker or a proton pump inhibitor.

At this point, the length of treatment is unknown and usually relies on a careful history of the patient’s interactions with the spike protein, time since last exposure, history of underlying autoimmune dysfunction, and overall functional symptomatology.

Dr. Vaughn’s treatments are driven by these factors, and typically lasts from one to three months. His hope is for a robust clinical trial soon to further inform length and identify additional surrogate clinical markers for clinicians to use to identify patients that would benefit from treatment.

Nutraceuticals for Thrombotic Conditions (Ref)

There are a variety of dietary supplements that may have a beneficial effect for thrombotic conditions (R).

Meanwhile, many of these compounds also have anti-inflammatory, anti-oxidative, and autophagy-boosting effects which are beneficial for COVID-related symptoms as well.

Flavonoids

Resveratrol has antiplatelet properties. It is a naturally occurring flavonoid primarily found in grapes, red wine, and peanuts.

A dose-dependent inhibitory effect of resveratrol on platelet aggregation has been observed in cellular and animal models.

Furthermore, resveratrol’s multiple effects of lowering of oxidative stress and inflammation, enhancing metabolic capacity, increasing nitric oxide synthesis by endothelial cells, and promoting autophagy are beneficial for patients with COVID related clotting issues as well.

A major component in green tea, epigallocatechin-3 gallate (EGCG) is believed to actively inhibit platelets in humans. EGCG targets multiple pathways to achieve this role.

Genistein, a tyrosine kinase inhibitor, is an inhibitor of platelet aggregation and has effects in preventing thrombotic occlusion in blood vessels. It is found predominantly in soy products.

Genistein’s primary mechanism at least includes to inhibit platelet aggregation induced by collagen,; and antagonistic effects for thromboxane receptors.

Garlic

The compounds of adenosine, allicin, and paraffinic polysulfides appear to be responsible for the inhibitory effect of garlic on platelet aggregation.

Derived from the cleavage of alliin by alliin lyase, allicin inhibits platelet activity in vitro without affecting cyclooxygenase, lipoxygenase, thromboxane, vascular prostacyclin synthase, or cyclic AMP levels.

Antioxidants

Well known for its antioxidant function, vitamin E has multiple beneficial properties for clotting conditions.

For example, it improves the activity of endothelium-derived nitric oxide, improves endothelial function in part due to the inhibition of protein kinase C (PKC), and inhibits platelet aggregation.

Vitamin E has been shown to decrease platelet adhesion to collagen, fibrinogen, and fibronectin, and increase platelet sensitivity to prostaglandin E1.

Selenium is a trace element and an essential component of glutathione peroxidase enzymes, protecting cells from oxidative stress. A deficiency in selenium is associated with an increased risk of arterial thrombosis.

Selenium has an effect of inhibiting platelet aggregation, primarily through inhibiting those substances forming blood clots.

Drug Interactions

The impact of dietary supplements on normal hemostasis and antithrombotic therapy should be given consideration.

Supplements that have been reported to affect normal coagulation and platelet activity and/or have been reported to possibly interact with coumarin anticoagulants include danshen, garlic , ginkgo, American ginseng, Asian ginseng.

However, most of these reports are either theoretical or consist of individual cases.

Intermittent Fasting

Intermittent daily fasting or periodic daily fasts has a profound effect on promoting immune system homeostasis, partly by stimulating autophagy and clearing misfolded and foreign proteins, promoting mitophagy and improving mitochondrial health, as well as increasing stem cell production. [R] Intermittent fasting likely has an important role in promoting the breakdown and elimination of the spike protein. 

FLCCC has launched i-Recover protocol for post-vaccine syndrome which include intermittent fasting as one of the most important first line treatments.

Some functional providers also believe intermittent fasting or time-restricted eating can help rejuvenate the immune system. Restricting feeding to shortened windows helps stimulate mitophagy (the removal of damaged mitochondria), Patrick Hanaway, MD, senior advisor to the CEO of the Institute for Functional Medicine, explains.

Fasting also supports the turnover of damaged cells throughout the body, making room for new, healthy mitochondria and cells to take their place.

Time-restricted eating can take a variety of forms. One of the most popular is simply eating all your day’s meals within an eight-hour window, then going 16 hours without food or calories. 

Exercise could help moderate the effects of Long COVID

Researchers from Pennington Biomedical Research Center (LA, USA) and the University of Pittsburgh (PA, USA) recently published their hypothesis on exercise as a moderator of persistent neuroendocrine symptoms of COVID-19, detailing how exercise could help counteract the detrimental inflammatory effects of Long COVID that cause sequelae such as depression and new-onset diabetes (Exercise and Sport Sciences Reviews: April 2022).

Vaccine Related Side Effects

On 26 May 2021, the COVID-19 subcommittee of the WHO Global Advisory Committee on Vaccine Safety (GACVS) issued a statement reviewing initial reports of mild myocarditis following COVID-19 mRNA vaccines. They also pointed out that "available data suggest that the immediate course of myocarditis and pericarditis following vaccination is generally mild and responds to conservative treatment (e.g. rest, treatment with non-steroidal anti-inflammatory drugs etc)."

For post vaccine syndrome treatment protocol, check out the I-Recover Post Vaccine Treatment Protocol.

Note: Low dose aspirin (75 mg) for two weeks post vaccination to reduce risk of clotting (patrickholford.com, drmalcolmkendrick.org).

COVID Jab Injuries Treatment for Kids

According to Dr. Michelle Perro, a pediatrician with more than 30 years of experience:

“If you're making spike [protein], even though kids don't have a lot of ACE2 receptors, those spikes are everywhere. In mice, it is shown that they cross the blood-brain barrier. They're disseminated, and then they tend to focus in your area of weakness.

They go into fat-loving tissues, they go into the ovaries, they seem to go everywhere. So, binding the spike protein, that's one aspect, and there are different things you can do, both pharmaceutical and non-pharmaceutical.

My favorite is ivermectin for the spike. I was giving kids 12 milligrams, initially, once a day. I went up to 12 mg twice a day for Omicron, but it depends on the size of the kid. For bigger kids, it’s 18 mg twice a day.

I didn't see any toxicity with ivermectin. I've used ivermectin before, mostly for parasitic infections, and I never had any problem with ivermectin. I have not used hydroxychloroquine before, but now, for Omicron, I would use hydroxychloroquine, 200 mg twice a day.

I use a lot of quercetin and zinc together ... To decrease inflammation, especially IL6, you also want to use a lot of immunomodulators, and a lot of supplements can do that.”

To learn more, see DrMichellePerro.com, and GMOscience.org, which is the non-profit she cofounded in 2014. 

Moving Forward

One of the pandemic’s few bright spots is the way it’s accelerated telehealth services. Patients now can have unprecedented access to a broad range of healthcare providers across the nation. 

Find healthcare providers:

• List of Doctors that will prescribe Ivermectin and Hydroxychloroquine
• List of Pharmacies that will fill Ivermectin
• www.ifm.org/find-a-practitioner (Functional Medicine)
• Post-COVID Care Centers (PCCC) by Survivor Corps

If you have symptoms that include major shortness of breath, cough with blood in it or pain on one side when you take a deep breath, it could be due to a late pulmonary embolism or a blood clot going to the lungs. Please visit your medical doctor or the nearest 24-hr medical emergency center immediately.

Z-Dtox Supplement 

Dr. Vladimir Zelenko’s groundbreaking work on the immune system has led to this exciting breakthrough.

Your immune system can be weakened by over 300 different primary immunodeficiency disorders, poor diet, lack of sleep, and adverse reactions to various vaccines.

That’s where Z-DTOX comes in! Z-Dtox is Dr. Zelenko’s proprietary combination of NAC, EGCG, Zinc, Vitamin C, and Vitamin D.

Ingredients:

• Epigallocatechin gallate (EGCG) is an extract of green tea and is a powerful zinc Ionophore (zinc delivery system).
• N-acetyl cysteine (NAC) is a supplement form of cysteine. It may prevent blood clots and is an antioxidant.
• Zinc is critical for immune cell development. Dozens of different enzymes in the body rely on zinc.
• Vitamin C is an essential nutrient involved in the repair of tissue and the enzymatic production of certain neurotransmitters.
• Vitamin D is a group of fat-soluble secosteroids responsible for increasing intestinal absorption of calcium, magnesium, and phosphate, and many other biological effects.

Z-Dtox is more powerful than Z-Stack. It has EGCG instead of Quercetin, NAC, and higher dose Zinc. It is more appropriate for higher risk patients. For example, those people that have a dysfunctional immune system, risk of blood clots, older people and those with chronic medical conditions.

Z-Dtox also has 60 servings per container instead of 30 servings per container for Z-Stack.

Where to buy Z-Dtox: Z-Dtox is available on Dr Zelenko's website. Here is the link: Z Dtox Supplement 

Note: To get 5% OFF, please use this coupon code: DRFRANCIS

Related:

• Long Haulers: World Council for Health Reveals Spike Protein Detox

• FLCCC I-MASK+ Prevention and Early Outpatient Protocol

• Bruce Patterson Long Hauler Protocol
  
  

Disclaimers: 

• This post is not medical advice. This post is for informational and educational purposes only.
• Always see or talk to your doctor before taking these drugs, supplements and over the counter products. Be aware that most of the 'treatment' dosages are above the recommended dietary allowance (RDA) and therefore such dosages should not be maintained on a long term basis. 
• Our aim here isn't to replace your doctors' advice. It is intended as a sharing of knowledge and information. Do take note that supplements are not 100% protective or curative against COVID-19.
• You still need to follow the advice given by CDC, WHO and your local authority in terms of local guidelines such as mask wearing, social distancing, vaccination and avoiding crowds. It's better to combine multiple strategies in order to defend yourself against this virus.
• According to US NIH: "...Guidelines should not be considered mandates. The choice of what to do or not to do for an individual patient is ultimately decided by the patient and their provider."

Related: 

Omicron and Long Haul Syndrome

How to Detox Spike Protein from Body