Glyphosate exposure to Chronic Kidney Disease of unknown etiology (CKDu) in Sri Lankan farmers

Since 1980, the American Association for the Advancement of Science (AAAS) — the world's largest scientific society and publisher of several journals, including Science — has presented an annual award for Scientific Freedom and Responsibility to "scientists, engineers or their organizations, whose exemplary actions have demonstrated scientific freedom and responsibility in challenging circumstances." As explained on the AAAS website:1

"The types of actions worthy of this award include acting to protect the public's health, safety or welfare; focusing public attention on important potential impacts of science and technology on society by their responsible participation in public policy debates; or providing an exemplary model in carrying out the social responsibilities of scientists, engineers or in defending the professional freedom of scientists and engineers.

Some awardees have risked their freedom and even physical safety by their actions, while others have been honored for their advocacy and their leadership."

2019 Award Winners

In 2019, the AAAS was slated to present the Scientific Freedom and Responsibility award to two human health researchers who have published papers linking glyphosate exposure to chronic kidney disease of unknown etiology (CKDu) in Sri Lankan farmers:

  • Dr. Sarath Gunatilake,2 former chair of the health science department at the University of California, whose areas of expertise include occupational and environmental health research.
  • Channa Jayasumana, Ph.D.,3 a faculty member of Medicine and Allied Sciences at the Rajarata University of Sri Lanka, who conducts research into nephrotoxins (kidney toxins) and the causes and treatments for chronic kidney disease.

Their paper "Glyphosate, Hard Water and Nephrotoxic Metals: Are They the Culprits Behind the Epidemic of Chronic Kidney Disease of Unknown Etiology in Sri Lanka?"4 was published in 2014, followed by "Simultaneous Exposure to Multiple Heavy Metals and Glyphosate May Contribute to Sri Lankan Agricultural Nephropathy,"5 and "Drinking Well Water and Occupational Exposure to Herbicides Is Associated With Chronic Kidney Disease in Padavi-Sri Pura, Sri Lanka,"6 in 2015.

In the third paper listed, the team found people who drank water from wells where glyphosate and heavy metal concentrations are higher had a fivefold increased risk of CKDu.

Award Winners Are Both Outspoken Critics of Glyphosate

Both Gunatilake and Jayasumana have previously taken a strong stance against glyphosate-based herbicides, highlighting the dangers of herbicide adjuvants. In a 2018 Daily Mirror article,7 Gunatilake noted that adjuvants added to glyphosate-based herbicides "are 1,000 times more toxic than glyphosate itself." He went on to say:

"The point I'm trying to raise is that glyphosate without adjuvants is not very useful. Therefore, manufacturers have added these toxic chemicals into glyphosate and nobody is talking about them! Over the last 25 years, the pesticide industry had us hoodwinked by referring only to glyphosate and not to the adjuvants or additives included in these herbicides."
Jayasumana, meanwhile, provided testimony8 at the yearlong International Monsanto Tribunal,9 which began December 2015, asserting that glyphosate use has resulted in ecocide.

In its February 4, 2019 press release,10,11 (which has since been removed from its website12), AAAS stated Gunatilake and Jayasumana "faced death threats and claims of research misconduct while working to determine the cause of a kidney disease epidemic that has claimed tens of thousands of lives in their home country of Sri Lanka and around the world. Ultimately, their advocacy led to the culprit, an herbicide called glyphosate, being banned in several affected countries."

Jessica Wyndham, director of the AAAS Scientific Responsibility, Human Rights and Law Program, said:13

"To right a wrong when significant financial interests are at stake and the power imbalance between industry and individual is at play takes the unique combination of scientific rigor, professional persistence and acceptance of personal risk demonstrated by the two scientists recognized by this year's award."

Award Retracted Amid Controversy on Glyphosate's True Danger

According to Gunatilake and Jayasumana, consumption of glyphosate-contaminated water may contribute to chronic kidney disease by facilitating the transport of heavy metals such as arsenic and cadmium into the kidneys.14

The AAAS award announcement incited a rash of criticisms by defenders of glyphosate, leading the AAAS to issue another statement just two days later, saying the organization is "taking steps to reassess the 2019 Award for Scientific Freedom and Responsibility, after concerns were voiced by scientists and members. This award will not be presented … as originally planned while we further evaluate the award selection."

(Incidentally, AAAS CEO Rush Holt announced his retirement that same day.15) One outspoken critic was Kevin Folta — a pro-GMO University of Florida professor caught intentionally hiding his funding from Monsanto — who claimed that the pair's 2014 paper merely "presented a hypothesis. There were no data. There were no experiments. It was a semi-well-crafted hypothesis that could be tested."16 In a commentary, rebuts Folta's claims, saying:

"Folta's claim that there are 'no data' in the paper is false. There are plenty of data in this and the authors' follow-up papers — from epidemiological and case-control studies, as well as geographical surveys — that support the idea that glyphosate herbicides should be withdrawn from use as a precautionary measure until they can be proven safe.

Are these data conclusive? No. They point to an association. It's true that the link between glyphosate exposure and chronic kidney disease will always remain a 'hypothesis' until it is proven in controlled long-term animal feeding studies …

The truth is that they are unlikely to be done, due to the massive expense and the unwillingness of industry and governments to fund studies that could show that they were responsible for exposing people to poisons over many years."

Should an Award Be Revoked Based on Controversial Findings?

True, Gunatilake and Jayasumana's theory is just one of dozens of hypotheses for what might be causing chronic CKDu.17,18,19 (Cadmium toxicity is on that list, though.) Overall, it doesn't appear as though any one given influence can explain all, or even most, cases of CKDu, so the search for answers continues.

The problem with the AAAS' revocation is that whether the research findings are absolutely "true" is not entirely relevant for this particular award. As tweeted by Jack Heinemann,20 a professor at the University of Canterbury in New Zealand, whose research topics include horizontal gene transfer, GMO risk assessment, conflicts of interest in research and sustainable agriculture:21

"Whether or not the link between glyphosate (or formulation) and kidney disease is right misses the point. A scientific freedom award is given for persecution. If you only give it for proven science, it would be delayed decades and it would only benefit those who persecute."

Gunatilake and Jayasumana are relatively cautious in their own conclusions, describing the link between glyphosate and CKDu as follows:22

"A strong association between the consumption of hard water and the occurrence of this special kidney disease has been observed, but the relationship has not been explained consistently. Here, we have hypothesized the association of using glyphosate, the most widely used herbicide in the disease endemic area and its unique metal chelating properties.

The possible role played by glyphosate-metal complexes in this epidemic has not been given any serious consideration by investigators for the last two decades … Although glyphosate alone does not cause an epidemic of chronic kidney disease, it seems to have acquired the ability to destroy the renal tissues … when it forms complexes with a localized geo environmental factor (hardness) and nephrotoxic metals."

Former AAAS President Is Now Biotech Shill

While it may seem cynical to cry foul at every turn, industry influence and conflicts of interest have become so commonplace these days that it simply cannot be ignored. In a recent tweet, science journalist Paul D. Thacker23 (who also had a hand in writing the Open Payments Act, which mandates the disclosure of compensation from the pharmaceutical and medical industry) noted:24

"If you ever worried that science was being warped by corporate interests, this backpedal by AAAS in giving an award to pesticide researcher [sic] should lay that to rest. Answer seems to be 'yes.'"

In a series of tweets, Thacker also points out links between former AAAS president Nina Fedoroff and the biotech industry, which has become well-known for pressuring medical journals and other organizations to revoke and discredit undesirable research and/or journalism.25

In 2015, Fedoroff, a plant molecular biologist, joined the OFW Law firm — which lobbies for the agrochemical industry — as senior science adviser for agriculture policy, global food security and government affairs.26

On its website in 2022, OFW plainly states that Fedoroff advises on “issues of agriculture, particularly the use of genetically modified organisms (GMO).”

To see how she now promotes herbicides for these crops, you need look no further than some of the glowing, feel-good articles she’s written about the so-called pluses of GMO crops, such as one she wrote for Genetic Literacy Project in 2020.27 It’s clear she’s fully on-board with GMO crops as well as the poisons they need to grow.

She was also present at the 2017 release of "Little Black Book of Junk Science,"28 a book by the American Council on Science and Health (ACSH), a chemical industry front group that I've written about on several occasions, and was a chosen speaker at a GMO Answers symposium cosponsored by Scientific American in 2016.29,30

Curiously, the “Little Black Book” is still available on different book sales sites such as Amazon, but has been removed from the ACSH website, as evidenced by the dead link for reference 27 in my sources list at the end of this article.

GMO Answers was created by the PR firm Ketchum, which works on behalf of the Council for Biotechnology Information31 to improve the public image of GMOs. U.S. Right to Know has previously called attention to a video ad in which the firm talks about how it doubled positive GMO coverage using online social media monitoring.32

AAAS Has 'Mixed Record on Public Interest Issues'

Considering how strong professional ties can be, even when officially severed, it doesn't seem farfetched to suspect Fedoroff's association with AAAS and the agrochemical industry might have an influence. GM Watch also notes:33

"The AAAS has a mixed record when it comes to public interest issues. In 2013 the AAAS' board of directors issued a statement opposing the labeling of GM foods in the U.S. … The AAAS was at the time chaired by Nina Fedoroff, who has close ties to the GMO industry.

But in an incident that showed that the AAAS is not monolithic but contains scientists who do not toe the GMO lobby's line, a group of scientists and physicians that included many long-standing AAAS members condemned the AAAS board of directors' statement as 'an Orwellian argument that violates the right of consumers to make informed decisions.'

They pointed to evidence showing that Roundup, the herbicide used on most GM crops, could pose risks that consumers might reasonably want to avoid. Sadly, the AAAS board seems more likely than its membership to have the power to decide on the fate of the award that was to be given to the Sri Lankan scientists."

Latest GMO Monopoly Driven by Fear

While glyphosate-based herbicides still dominate the global market, rapidly mounting weed tolerance has led to the introduction of dicamba-based herbicides and a new crop of genetically engineered (GE) plants designed to withstand it. Dicamba is an incredibly potent toxin, and dicamba drift damaged or destroyed an estimated 3.6 million acres across the U.S.34 between 2016 and 2017 alone.

This included not only fields growing nondicamba-resistant crops but also trees. In response, the U.S. Environmental Protection Agency placed some restrictions on dicamba usage. For instance, special training is required to apply the herbicide, and its application is prohibited when wind speeds are greater than 10 mph. Farmers are also asked to assess the risk that spraying could have on nearby crops, as well.

Despite this, reports of damage from dicamba drift continued through 2018. What's worse, many farmers reported feeling they have no choice but to buy Monsanto-Bayer's GE dicamba-tolerant seeds, or else they risk having their crop destroyed by dicamba drift from their neighbors.

Randy Brazel, a soybean grower, told NPR35 he had little choice but to switch to dicamba-tolerant soybeans after one of his neighbors called saying he was making the switch. NPR writes:

"[D]icamba fumes from fields of Xtend soybeans have curled up the leaves of sycamore trees and millions of acres of traditional soybeans across much of the Midwest and South. Brazel wasn't willing to take the risk of that happening to his crops.

He canceled his entire order and bought the new dicamba-tolerant soybeans instead. 'Then I have to get on the phone and call every other neighbor and say, 'Listen, I did not want to do this. But I am going to be forced to go dicamba.' Well, then that forces all those neighbors to call all their neighbors. And eventually what you have is a monopoly,' he says."

In some parts of the U.S., protecting your crop from dicamba damage from neighbors is part of the sales pitch for the dicamba-resistant Xtend soybeans, NPR reports. In response to this mounting pressure to switch or lose your farm, a lawsuit has been filed against Monsanto on behalf of farmers, arguing the dicamba-tolerant seeds violate antitrust law.

As noted by NPR, "The lawsuit claims that the company understood that the risk of drifting dicamba could drive competitors out of the market."

Bayer (which bought Monsanto in May, 2018) asked for the lawsuit to be dismissed, but in 2020, a jury not only ordered a $265 million judgment against Bayer,36 but a U.S. appeals court also blocked them from selling any more dicamba.37 Subsequently, in May 2021, Bayer set aside $300 million to cover multiple farmers' claims and their attorneys’ fees.38

That hasn’t ended Bayer’s plans for dicamba, however, as in March 2022, a federal district court judge in Arizona ordered the EPA to file a report on its dicamba investigations by May 15, 2022, in answer to a request by the Center for Food Safety and Center for Biological Diversity to “vacate the registration of three dicamba herbicides: XtendiMax (Bayer), Engenia (BASF) and Tavium (Syngenta).”39

Substantial Amounts of Glyphosate Found in Food

The sad fact of the matter is, if you're eating nonorganic foods, especially processed food, then you're eating glyphosate on a regular basis. Farmers apply nearly 5 billion pounds (over 2 billion kilograms) of glyphosate to farm crops each year, worldwide.40 Approximately 300 million pounds are applied on U.S. farmland.

Testing has revealed 70% of Americans had detectable levels of glyphosate in their system in 2016; between 1993 and 2016, the glyphosate levels in people's bodies increased by 1,208%.41 A recent investigation by journalist Carey Gillam42 revealed Roundup has been found in virtually all foods tested, including granola and crackers.

The Health Research Institute Labs (HRI Labs) has also conducted glyphosate testing, finding the chemical in Ben & Jerry's ice cream.43 Other foods typically contaminated with glyphosate include grains, legumes, beans, orange juice and wine.

HRI's testing also revealed people who eat oats on a regular basis have twice as much glyphosate in their system as people who don't (likely because oats are desiccated with glyphosate before harvest). Meanwhile, people who eat organic food on a regular basis have an 80% lower level of glyphosate than those who rarely eat organic.

Glyphosate May Affect Your Health in Several Ways

Glyphosate actually has a glycine molecule as part of its structure (hence the "gly" in glyphosate). Glycine is a very common amino acid your body uses to make proteins. Laboratory investigations by research scientist Anthony Samsel found that glyphosate becomes part of animal proteins and particular the collagens which form 25% to 35% of our bodies structural proteins.

Samsel and his coauthor senior scientist at MIT, Stephanie Seneff, also believe your body can substitute glyphosate and its metabolite AMPA into peptides and proteins, which results in damaged peptides and proteins being produced.

Glycine also plays a role in quenching inflammation, and is used up in the detoxification process. As a result of glyphosate toxicity, many of us may not have enough glycine for efficient detoxification. According to research published in the journals Entropy in 2013 and in the Journal of Biological Physics and Chemistry in 2017, the main toxic effects of glyphosate are related to these facts that it:44,45,46

  • Inhibits human digestive enzymes leading to malabsorption with numerous health consequences. Glyphosate was found by Samsel contained with purified digestive enzymes pepsin, trypsin and lipase. Further analysis by high performance liquid chromatograph of lipase found glyphosate to chemically bond and irreversibly inhibit this enzyme.
  • Hormone-sensitive lipase in humans is responsible for lipid hydrolysis and cholesterol ester hydrolysis. Impaired function has been linked with atherosclerosis, obesity and type 2 diabetes among others
  • Inhibits the shikimate pathway, found in gut bacteria in both humans and animals
  • Interferes with the function of cytochrome P450 enzymes, required for activation of vitamin D in the liver, and the creation of both nitric oxide and cholesterol sulfate, the latter of which is needed for red blood cell integrity
  • Chelates important minerals, including iron, cobalt and manganese. Manganese deficiency, in turn, impairs mitochondrial function and can lead to glutamate toxicity in the brain
  • Interferes with the synthesis of aromatic amino acids and methionine, which results in shortages in critical neurotransmitters and folate
  • Disrupts sulfate synthesis and sulfate transport

Glyphosate also disrupts, destroys, impairs or inhibits:47

  • The microbiome, thanks to its antibiotic activity
  • Sulfur metabolism
  • Methylation pathways
  • Pituitary release of thyroid stimulating hormone, which can lead to hypothyroidism

How to Test Your Glyphosate Level

The chemical has also been linked to an increased risk of Non-Hodgkin lymphoma and lung cancer.48 Considering the possible dangers of glyphosate, it would make sense to minimize your exposure, and if you have high levels already, to take steps to detoxify it.

HRI Labs has developed home test kits for both water and urine, and if you have elevated levels, you can drive out the glyphosate by taking an inexpensive glycine supplement.

Solutions for Glyphosate Toxicity

As the realities of glyphosate toxicity grow, there are steps you can take to protect yourself, starting with limiting your exposure by eating organic or biodynamically grown food as much as possible. Consuming organic, unpasteurized apple cider vinegar is another strategy, as it contains acetobacter, which can break down glyphosate.

"We make salad dressing [with apple cider vinegar]," Stephanie Seneff, a senior research scientist at the Massachusetts Institute of Technology, says. "We have salad for dinner and I think it can actually help you to break down whatever glyphosate is in your mouth, because it will get right to work turning glyphosate into useful phosphorous. It completely gets rid of it."

Seneff also suggests eating garlic and cruciferous vegetables, which are good sources of sulfur. Glycine supplementation may also be a good option to help detoxify glyphosate. To eliminate glyphosate, you need to saturate your body with glycine.

Dr. Dietrich Klinghardt, who is a specialist in metal toxicity and its connection to chronic infections, recommends taking 1 teaspoon (4 grams) of glycine powder twice a day for a few weeks and then lower the dose to one-fourth teaspoon (1 gram) twice a day. This forces the glyphosate out of your system, allowing it to be eliminated through your urine.

Collagen is naturally rich in glycine, but if going this route, I recommend looking for organic grass fed collagen only. Organic bone broth is another excellent source of glycine-rich collagen.

Sources and References

This original article was previously published February 20, 2019 on, and has been updated with new information.




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