Zelenko Protocols: COVID-19 Prophylaxis and Treatment (May 2022)
What is the Zelenko protocol? The Zelenko COVID-19 Protocol was developed by Dr Vladimir Zelenko. A retrospective study analyzing Dr Zelenko's patient data was accepted for publication in the International Journal of Antimicrobial Agents after a rigorous peer review process. The study finds that early intervention and treatment of high-risk patients with COVID-19 resulted in significantly fewer hospitalizations and deaths. The treatment consisting of zinc, low-dose hydroxychloroquine (HCQ), and azithromycin, is also referred to as "The Zelenko Protocol." Dr Zelenko has since updated his protocols to incorporate new evidence.
Update: Recently, Ivermectin has come to the fore as a more effective (also long standing, cheap, generic drug), in all three stages of COVID-19. Dr Zelenko has also updated his protocols to incorporate ivermectin as an option for both the prophylactic and treatment protocols as shown below.
IntroductionThis webpage compiles content related to the early outpatient treatment protocol that has been proposed by Dr. Vladimir Zelenko for the SARS-CoV-2 virus. Dr. Zelenko originally risk-stratified patients and treated high-risk patients with hydroxychloroquine, zinc, and azithromycin.
Zelenko Covid-19 Prophylaxis Protocol
Low Risk Patients - Young healthy people do not need prophylaxis against COVID-19. In young and healthy people, this infection causes mild cold-like symptoms. It is advantageous for these patients to be exposed to Covid-19, build up their antibodies and have their immune system clear the virus. This will facilitate the development of herd immunity and help prevent future Covid-19 pandemics. However, if these patients desire prophylaxis against Covid-19, then they should take the protocol noted below.
Moderate Risk Patients - Patients from this category are healthy but have high potential viral-load exposure. This group includes medical personnel, caregivers of high-risk patients, people who use public transportation, first responders and other essential personnel who are crucial to the continued functioning of society. These patients should be encouraged to take prophylaxis against Covid-19 in accordance with the protocol noted below.
High Risk Patients - Patients are considered high risk if they are over the age of 45, or if they are younger than 45 but they have comorbidities, that is, they have other health conditions that put them at risk. These patients have between a 5 to 10% mortality rate if they are infected with Covid-19. These patients should be strongly encouraged to take prophylaxis against Covid-19 in accordance with the protocol noted below.
- Zinc is critical. It helps block the virus from multiplying. Hydroxychloroquine is the carrier taking zinc INTO the cells to do its job.
- Vitamin D3: Preferable in oil capsules for better absorption.
- Inorganic zinc such as zinc sulfate, is not as effective or useable by your body as chelated zinc sources. Zinc lozenges are preferred so that the tissues of the nose and throat are rich in zinc as soon as they encounter the virus
In an effort to make it easier for patients, Dr Zelenko has developed an oral supplement that contains all four key ingredients: vitamin C, quercetin, vitamin D3 and zinc. It’s referred to as 'Z-Stack Supplement'.
Z-Stack Vitamin cocktail provides key ingredients needed in order to help your body fight off this deadly invader. The Z-Stack Vitamins are Kosher certified, GMP certified and made in the USA.
Note: To get 5% OFF, please use this coupon code: DRFRANCIS
Zelenko Protocol - Treatment Plan for Patients with Covid-19 symptoms
Fundamental Principles (Dr Zelenko Protocol When to Start)
Patient CategoriesLow risk patient - Younger than 45, no co-morbidities, and clinically stable
High risk patient - Older than 45, younger than 45 with co-morbidities, or clinically unstable
Treatment OptionsLow risk patients
- Supportive care with fluids, fever control, and rest
- Elemental Zinc 50mg 1 time a day for 7 days (PubMed)
- Vitamin C 1000mg 1 time a day for 7 days
- Vitamin D3 5000iu 1 time a day for 7 days
- Elemental Zinc 50-100mg once a day for 7 days
- Vitamin C 1000mg 1 time a day for 7 days
- Vitamin D3 10000 iu once a day for 7 days or 50000 iu once a day for 1-2 days
- Azithromycin 500mg 1 time a day for 5 days or
- Doxycycline 100mg 2 times a day for 7 days
- Hydroxychloroquine (HCQ) 200mg 2 times a day for 5-7 days and/or
- Ivermectin (IVM) 0.4-0.5mg/kg/day for 5-7 days. Either or both HCQ and IVM can be used, and if one only, the second agent may be added after about 2 days of treatment if obvious recovery has not yet been observed etc. (Find a Doctor)
Editor's Note on Vitamin D3: Preferable in oil capsules for better absorption.
- If you simply cannot get hydroxychloroquine or ivermectin, quercetin is a viable stand-in. Quercetin works best when taken with vitamin C and Bromelain, as vitamin C helps activate it and bromelain helps with the absorption.
- Dexamethasone 6-12mg 1 time a day for 7 days OR Prednisone 20mg twice a day for 7 days, taper as needed (not suitable during viral phase)
- Budesonide 1mg/2cc solution via nebulizer twice a day for 7 days (not suitable during viral phase)
- Blood thinners (i.e. Lovenox, Eliquis, Xarelto, Pradaxa, Aspirin) (Amazon)
- Colchicine 0.6mg 2-3 times a day for 5-7 days (MedRxiv 2021)
- Monoclonal antibodies
- Home IV fluids and oxygen
- Curcumin: 500 mg twice a day (Ref) (Amazon)
- Fluvoxamine: 50 mg twice daily for 10–14 days. Add to ivermectin if: 1) minimal response after 2 days of ivermectin; 2) in regions with more aggressive variants; 3) treatment started on or after day 5 of symptoms or in pulmonary phase; or 4) numerous co-morbidities/risk factors. Avoid if patient is already on an SSRI (selective serotonin reuptake inhibitor).
- If you can’t get fluvoxamine (Luvox), using 30mg once a day of fluoxetine (Prozac) is equally effective (equivalent to 50mg twice a day of fluvoxamine).
- Pulse Oximeter: Monitoring your oxygen saturation with a pulse oximeter and to go to the hospital if you get below 94%. (Amazon)
- Mouthwash: 3 x daily – gargle (do not swallow) antiseptic mouthwash with cetylpyridinium chloride (e.g. Crest, Scope mouthwash™), ListerineTM with essential oils, or povidone/iodine 1 % solution as alternative (Betadine® Antiseptic Sore Throat Gargle™). (Ref)
- Nasal Spray: Xlear Nasal Spray with Xylitol (Ref) (Amazon)
- Aspirin: 325 mg/day unless contraindicated. (Amazon) (not suitable during viral phase)
- Bromhexine 8 mg three times a day (Ref) (Lazada Malaysia*)
About Dr Vladimir ZelenkoHe graduated with a B.A. degree with high honors in Chemistry from Hofstra University. After receiving an academic scholarship to attend S.U.N.Y. at Buffalo School of Medicine, he earned his M.D. degree in May 2000. Dr. Zelenko completed his family medicine residency at South Nassau Communities Hospital in Oceanside, N.Y. in May 2004. Since then, Dr. Zelenko has practiced family medicine in New York’s Hudson Valley. He has been described by his patients as like a family member to thousands of families, and is a medical adviser to the volunteer ambulance corps in Kiryas Joel, New York.
When asked about studies that seemed to discredit the efficacy of
HCQ in treating the Chinese coronavirus, Zelenko explained “You don’t fire a gun without a bullet in it and then say the
gun doesn’t work when you don’t kill the target. The studies that
were done on HCQ did not include the use of Zinc. HCQ is what
opens the cell and enables Zinc to attack the virus. One is not
effective without the other, or without a suitable substitute for
HCQ. The studies were designed to fail.”
Dr. Zelenko says that both prophylaxis measures and actual case treatments need to be customized to the individual. As a general rule, he says, those people who are in the higher risk groups, both by age and by other pre-existing conditions, require more aggressive actions on both the preventative and diagnostic side.
“This virus remains relatively stable inside the host for about the first five days,” Zelenko says. “After that it starts to multiply rapidly. It also starts to migrate from sinus to lungs and cardio areas where involvement becomes more severe and treatment becomes more difficult. The key is early intervention.” Zelenko again mentioned his 84% success rate in high-risk patients.
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