Best Protein Powder for Weight Loss and Muscle Gain Male 2023

Higher-protein diets have been promoted over the past 20 years for being an effective strategy to treat or prevent obesity through body weight control. Modulations in energy metabolism, appetite, and energy intake are thought to be partially responsible for these improvements.

How Protein Powder Helps in Weight Loss and Muscle Gain?

i. May Reduce Hunger and Appetite

Ghrelin is an orexigenic hormone that induces food intake by increasing hunger, and its plasma concentration is decreased by protein intake. Studies found that liquid preloads containing protein rather than glucose significantly suppressed ghrelin release.

In conclusion, dietary protein elevates GLP-1, CCK, and PYY levels, which are secreted in the gut and diminish appetite while also decreasing ghrelin levels, which increases appetite. Such changes in the release of satiety hormones constitute an important mechanism of HPD-induced weight loss. (Source)

ii. May Promote Lean Body Mass and Reduce Fat Mass

Protein shakes may temporarily boost your metabolism. It can also help you gain muscle, particularly if you follow it with strength exercise and a low-calorie diet. 

A study showed that consumption of a diet with higher protein was more effective than consumption of a diet with lower protein in promoting increases in lean body mass and losses of fat mass when combined with a high volume of resistance and anaerobic exercise. 

Whey Protein vs Casein Protein

Whey and casein are the two main milk derivatives available to those who want milk proteins. Let’s dig deeper, what’s the differences between these two types!

Whey vs Casein Protein
Whey is the “faster” protein because its amino acids are quickly absorbed by out body. As a result, it serves as a good source of protein for a pre- or post-workout snack. While casein is the “slower” protein since it’s digested more slowly. Therefore, people might choose to consume casein before fasting or sleeping.

Is Casein or Whey Better for Weight Loss?
A study compared weight loss diet with either whey or casein supplements on overweight men for 12 weeks, showed that those taking casein supplements lost an average of 8% of their body weight. Those taking whey lost an average of 4%.

However, another study showed no significant difference between whey and casein for weight loss, making them equally as good for weight loss.

Best Protein Powder for Weight Loss and Muscle Gain Male

A. Best Whey Protein Powder

1. Optimum Nutrition Gold Standard 100% Whey Protein Powder (Chocolate Peanut Butter)

Optimum Nutrition Gold Standard 100% Whey Protein Powder (Chocolate Peanut Butter)


Whey Protein Isolates (WPI) are the purest form of whey protein that currently exists. By using WPI as the primary ingredient along with premium ultra-filtered whey protein concentrate (WPC) in Gold Standard 100% Whey, we’re able to pack 24 grams of protein into every serving to support your muscle building needs after training.

ON’s attention to detail extends to mixability. This superior quality powder instantly mixes using a shaker or a glass and spoon.

Whey Protein Isolate (WPI) Main Ingredient
– Over 4 Grams of Glutamine & Glutamic Acid in Each Serving
– 24g of Whey Protein
– 5.5g of Naturally Occurring BCAAs

4.7 out of 5 – more than 68,100 global ratings

Optimum Nutrition Gold Standard 100% Whey Protein Powder Reviews
I've Used Whey protein for years. I love that it's doctor recommended. It's especially great to have after a workout because it has nutrients that are designed for muscle growth and muscle repair. Despite the price still worth it because the container lasts a long time so the cost balances out. Additionally, since I started making protein shakes I have lost over 35 pounds and look and feel much better.

2. Dymatize Elite 100% Whey Protein Powder (Vanilla)

Dymatize Elite 100% Whey Protein Blend Powder


Elite Whey provides 25 grams of 100% Whey Protein per serving. Whey is considered to be the best source of protein due to its high Biological Value (BV), Amino Acid Profile, and fast absorption to give your body what it needs to build muscle and recover. 

Each serving of Elite Whey delivers 5.5 grams of Branched-Chain Amino Acids (BCAAs), which are depleted during intense training. BCAAs help promote the building of protein, as well as help with speeding recovery. Elite Whey also delivers 2.7 grams of L-Leucine, the BCAA that is directly involved in activating muscle protein synthesis, the process that builds your muscles and allows you to get stronger.

4.6 out of 5 - more than 16,000 global ratings

I've been using Dymatize protein for about two years now. Excellent protein content and BCAA's. Does it taste like a Hershey's chocolate bar? NO! Is it disgusting to drink? NO! Does it help you build muscle? YES! Stop whining, put your purse down, lift heavy and drink your protein!

3. Jocko Mölk Protein Powder (Chocolate Peanut Butter)

Jocko Mölk Protein Powder (Chocolate Peanut Butter)


– Jocko Mölk
Designed and engineered with a time-release blend of whey concentrate, whey isolate, micellar casein, and egg. This whey isolate protein powder slowly digests in your system and fuels muscle growth and muscle recovery all day long.

– Amino Acids
Blended with a plethora of amino acids, the building blocks of protein, these necessary components help your body with building muscle and regulating immune function. Check out the amino acid profile on the bottle!

– Digestive Enzymes & Probiotics
With added digestive enzymes and probiotics to fuel growth and muscle recovery all day long, Mölk’s complex mix of digestive enzymes and probiotics keeps your gut in check and ensures everything moves smoothly.

– Grass-fed Protein, No Hormones or Soy
We’ve developed the best protein powder from four different types of protein: whey protein concentrate and isolate, casein, and egg. Our whey protein powder comes from happy, grass-fed cows and is soy- and hormone-free.

– Sugar Free Chocolate Peanut Butter Flavor
Get your protein shake without the unwanted sugar. Mölk is sweetened with monk fruit only. It has no added sugar, no artificial sweeteners, and no added flavors.

4.7 out of 5 – more than 4,750 global ratings

Jocko Mölk Protein Powder Reviews
The flavor is great, is does get altered with Amino acids like glutamine, I wouldn't mix the two after workout. I like that it has less calories and sodium than other proteins. Definitely a easy way to get protein and easy to drink. I have used for about two month and notice a difference in muscle mass and strength. Very easy to drink and I never get the full feeling like drinking a shake or from gaining water weight. Very lean and my preferred protein, will try other flavors.

4. Ghost Whey Protein Powder

Ghost Whey Protein Powder


– Versatile and Delicious AF
GHOST WHEY protein combines a premium, fully disclosed whey protein blend, a few natural digestive enzymes, and out-of-this-world Peanut Butter Cereal Milk flavor. 26 servings.

– 26g Whey Protein
Every scoop of GHOST Peanut Butter Cereal Milk Whey contains 26G of pure, fully disclosed whey protein. Flip the tub around for a breakdown of exactly how many grams of whey protein isolate, concentrate, and hydrolysate are in every scoop.

– Soy and Gluten Free
While most brands use soy lecithinated whey protein, we opted to use only sunflower lecithinated whey protein. Why? For starters, soy is one of the common allergens on the market today. Additionally, soy contains phytoestrogens that mimic the body’s natural estrogen hormones, which isn’t great for anyone. And ZERO gluten. Enough said.

– Total Transparency
All GHOST products feature a transparent label that fully discloses the dose of each active ingredient. Zero proprietary blends means you know what you’re getting in each and every scoop.

4.5 out of 5 – more than 3,000 global ratings

Ghost Whey Protein Powder Reviews
If you’re bulking up or building muscle and want a good base for your protein shake. This is one of my favorites for that. Flavor is there, just wish I could have a little bit more of those larger chunks of the cookies part of the cookies n creme. But all in all, it’s great. It doesn’t taste so badly like those other protein shakes where you can feel the artificial-ness of the flavor. Also use it for other things like in overnight oats or in baking. Definitely grabbing another when I run out.

5. Jay Robb Whey Isolate Protein Powder

Jay Robb Whey Isolate Protein Powder


– The Real Whey
Jay Robb Whey Isolate Powder is a clean, delicious, and protein-packed way to promote your health goals.

– Build + Repair
Whey protein helps fuel the process to build new muscle faster and support metabolism.

– Nutrition Made Delicious
Nourishing your body is easy and outrageously delicious with flavors like vanilla, chocolate, strawberry, and more.

– Easy to Blend
Our easy-to-mix formula simplifies getting your protein on the run, in the gym, or at home

4.6 out of 5 – more than 4,950 global ratings

Jay Robb Whey Isolate Protein Powder Reviews
I love everything about the Jay Robb Whey Vanilla Isolate Protein Powder. It tastes great, mixes well with water, milk or milk substitute and the protein quality is high. Since incorporating this as an additional protein source, I feel more energetic and hope it enables me to increase my muscle mass.

B. Best Casein Protein Powder

6. Dymatize Elite Casein Protein Powder (Vanilla)

Dymatize Elite Casein Protein Powder (Vanilla)


Dymatize Elite Casein provides 25 grams of slow digesting Casein protein per serving. Dymatize 100% Casein is specifically designed to digest more slowly in your body than other rapid release protein sources, such as whey. This slow digestion is a result of the natural pH sensitivity of Casein protein in the digestive track.

Because of the natural thickening effect of Dymatize 100% Casein in the low pH environment of the stomach, a prolonged and steady release of protein is obtained. In fact, the resulting digestion can take more than twice as long as other forms of protein. This delayed digestion is often desirable, especially at bedtime or other periods when your body may go for an extended period without food.

4.6 out of 5 – more than 6,650 global ratings

Dymatize Elite Casein Protein Powder Reviews
I have the chocolate flavor and I love it, tastes the best with water. I am a huge sugar addict and it helps with my sugar cravings so I can have this instead of brownies or something. I am working out and trying to eat well so I am not sure the exact difference its making as far as building muscle because I do see results but I have also made dramatic changes. My favorite part of this is the help I get with my sugar cravings and it motivates me to workout since I kind of use it as a reward for myself at the end of the day.

7. Optimum Nutrition Gold Standard 100% Micellar Casein Protein Powder (Cookies and Cream)

Optimum Nutrition Gold Standard 100% Micellar Casein Protein Powder (Cookies and Cream)


Faster digesting protein is desirable immediately before and after exercise to help refuel recovering muscles, but slow digestion and absorption may be more beneficial at other times including bedtime when your body typically goes for hours without food.

Casein products are acid sensitive and thicken in the stomach. Compared to some other proteins, it can take longer for our gold standard 100% casein to be broken down into its amino acid subcomponents. By using only premium micellar casein as a protein source, we’ve created a formula that sets the standard for slow digesting protein support.

4.7 out of 5 – more than 900 global ratings

Seeking Health Histamine Block Reviews
Has helped my muscle gain and weight loss, and no longer wake up starving. Mixes well and tastes great ON is the best!

8. Ascent Native Fuel Casein Protein Powder (Chocolate)

Ascent Native Fuel Casein Protein Powder (Chocolate)


– Zero Artificial Ingredients
Ascent Micellar Casein contains zero artificial ingredients or flavors. It is naturally sweetened and contains 0g of sugar. Ascent is also Gluten Free, and Informed Sport Labeled – meaning it’s free of any banned substances.

– Slow Digesting, Repair While You Sleep
Ascent Micellar Casein is a slow-digesting protein, taking up to 6-8 hours to digest. Take before bed for sustained recovery to help prevent muscle loss during sleep. Ascent Micellar Casein is a great low calorie, low sugar option that can help with muscle repair and recovery.

– Perfect Nighttime Recovery Snack
Simply mix one scoop of Ascent Micellar Casein with 5oz of liquid (we recommend almond milk) and you have a delicious high-protein pudding. Best served chilled!

4.5 out of 5 – more than 1,800 global ratings

Ascent Native Fuel Casein Protein Powder Reviews
I really like the taste of this protein, it’s just right. I drink it right before I go bed after working out. My metabolism is really high so it’ll take me a while to gain muscle, but this should help out!


a. Protein Powder Side Effects

Protein powders are considered safe, but if you consume a lot of it, you may experience digestive adverse effects.

Dairy-based protein powder may cause stomach distress, bloating, and gas if you are lactose intolerant or otherwise sensitive to lactose. Choose a plant-based protein powder instead, or try with whey protein isolate, which has a lower lactose content than other dairy protein powders.

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