Best NAD+ Supplements 2021

What is NAD+ and What is its Function?

Nicotinamide adenine dinucleotide (NAD) is a coenzyme found in all living cells. It exists in two forms: an oxidized form and a reduced form, which are NAD+ and NADH (H for hydrogen).

It is central to energy metabolism and maintaining proper cell function. It plays a crucial role for our mitochondria function, which turn food and oxygen into energy for our body to use. NAD+ also supports the function of sirtuins. Sirtuins are proteins that help protect cells from age-related decline, regulate biological pathways and turn certain genes on and off. However, NAD+ levels decline with age which drive the aging process.


The key question is what ratio of NAD+ does your body need compared to NADH. While the optimal NAD to NADH ratio remains elusive, research suggests that a generally higher NAD to NADH ratio is favorable. 

When it comes to a plain NAD label, it’s not wrong to be identified as a NAD booster. Generating more NAD+ will naturally generate more NADH. However, the specificity of NAD+ is more indicative of what your cells are truly building when using NAD+ boosting supplements.

Read more at NAD+ and NADH: What's the Difference?

How can I increase my NAD+ naturally?

- Exercise

- Reduce sun exposure

- Spend more time in warm places, like hot tubs or saunas

- Consume more food with Vitamin B like avacoados, steam fish or milk

- Consume fermented food and drinks which contain NAD+ like sauerkraut and kombucha

- Intermittent fasting : Popular fasting plans often include 16- to 24-hour fasting periods twice a week, followed by healthy meals. This eating pattern triggers body shock, which can boost your natural supply of NAD+.

- Ketosis Diets : a low-carb, high-protein, healthy fats food plan.

Do NAD+ Supplements Work?

The answer may not be a single or straightforward one. NAD+ is a ubiquitous and fundamental molecule, involved in many biological pathways and cellular operations. Its ingestion could lead to a mix of positive and negative outcomes, the balance of which might depend on context. NAD+ precursors, consumed orally, may be taken up by some tissues more than others. And different cell types are known to employ distinct metabolic programs, which could lead to tissue-specific responses to NAD+.

Listed below are some of the best NAD+ Supplements in the market.

Best NAD Supplements 2021

1. Tru Niagen

- Reduces the cellular effects of aging by elevating NAD+, a key coenzyme your body uses for healthy cellular metabolism.
- Nicotinamide Riboside for Energy, Metabolism, Vitality, Muscle Health, Healthy Aging, Cellular Repair 
- Unlike NMN, our key ingredient Niagen was successfully notified two times as an NDI (New Dietary Ingredient) and reviewed as GRAS (Generally Recognized As Safe) under the United States notification programs.
- 120 count / Serving Size: 2 Capsules - Servings Per Container: 60

Everyday Renewal
Tru Niagen takes repair down to the foundation of our health, your cells. Every day, our cells are exposed to environmental toxins, hazardous compounds, and pathogens. These environmental factors and pathogens attempt to attack our DNA. Tru Niagen helps counteract this damage by activating tiny repair enzymes called sirtuins.

Fight Daily Stressors
Things like poor diet, alcohol consumption, lack of sleep, sun-exposure, and lack of exercise can be taxing on the body. These stressors affect us on the cellular level, putting our cells into overdrive in order to repair the damage. Tru Niagen helps combat these metabolic stressors.

Fitness Support
Tru Niagen helps fuel your workout and helps you recover after. It gives you fuel by supercharging your cells—focusing on continuous energy, not jolts of energy. After your workout is over, Tru Niagen helps you recover from intense exercise by boosting NAD+, a key coenzyme needed for cellular repair.

Lasting Energy
Tru Niagen promotes natural energy production deep in your cells. There are no stimulants like caffeine added. Tru Niagen helps provide every day sustaining energy through your body's natural energy-generating mechanisms.

While this is not a scientific review I have been taking Niagen in one form or another non stop for several years. I have been gradually increasing my doses with what I can only describe as a profound effect. Without a doubt I feel younger than 46. I also think I look younger than most people my age. I certainly don't feel my age and have a ton of energy every single day. I also try to eat plenty of vegetables with lots of non meat proteins along with limited meat consumption. I am not a health nut but basically try to stay away excess sugars and processed foods whenever I can. I also do a hard bike ride once or twice a week. I think this also helps the entire aging process some.

4.5 out of 5 - 2,408 global ratings

2. Toniiq NMN Powder

- Boost NAD+ Levels - Nicotinamide Mononucleotide Powder Supplement

- Highly Purified Form of NMN Powder 
- Our NMN powder contains an unprecedented purity level of 99+% (other NMN supplements and NAD supplement products won't disclose their purity levels).
- Fully Stabilized - NMN typically needs to be kept cold (fridge or freezer) because of its short shelf life. Our NMN formula comes in a completely shelf-stable non-refrigerated form and is packaged and sold in black sealed bottles that block light, moisture, and oxygen to ensure maintained and maximum potency.
- Toniiq products are produced in a GMP-certified and NSF-approved state-of-the-art manufacturing facility right here in the USA.
- We test each batch both ourselves and through a third-party independent laboratory to ensure our ingredients contain the correct standardized level of purity and active ingredients. We also test each batch for any possible additives, contaminants, and impurities to ensure the highest level of quality.

I have been using Toniiq NMN along with Resveratrol for about 7 and a half months now. I started taking these for longevity purposes after reading about them in Lifespan. Unexpectedly, I started to see my male pattern baldness reversing about 4 months in; I was not expecting this. Based on the regrowth process speed, it appears I'll reverse 8 years of hair loss in less than a year! My barber is totally floored that hair follicles can come back to life. I can only assume the cells in the rest of my body are rejuvenating as well.

I had been taking the NMN in pill form, but the powder seems to be a much better value. It has a slight tart flavor which I actually enjoy. I've only been using this new form for a short time, but I expect to continue to see the same results.

4.6 out of 5 - 295 global ratings

3. aSquared Nutrition Nicotinamide with Resveratrol

aSquared Nutrition's maximum strength Nicotinamide supplement is enhanced with Resveratrol to promote cellular health & repair, normal NAD levels, longevity and anti-aging. Our unique formula helps your cells metabolize & synthesize nutrients more effectively to boost energy. 

- 120 capsules per bottle
- 500mg of Nicotinamide per Capsule / 100mg of Resveratrol powder per Capsule
- Contains 500mg of Non-Flush vitamin B3 per vegetable capsule, and is enhanced with 100mg of Resveratrol powder (7% potency yield) to promote cellular health & repair, normal NAD levels, longevity and anti-aging. 
- Made in USA
- All Natural, Non-GMO, and Vegetarian
- Third Party Tested for Quality & Purity
- Supplement Pills to Support NAD, Anti Aging Skin Cell Health & Energy
- Complex contains powerful antioxidants and anti-inflammatory properties to combat poor aging. 
- Resveratrol is not suitable for people undergoing blood-thinning medication

Nicotinamide + Resveratrol Formula Benefits

- Promotes Cellular Health & Repair 
- Supports DNA Health & Wellness 
- Supports Longevity & Anti-Aging 
- Helps Boost Energy Levels 
- Supports Upregulation of Sirtuin Pathway 
- Supports Normal NAD / NAD+ Levels 
- Powerful Antioxidant Properties 
- Helps Boost Skin & Immune Health 
- Contains Anti-Inflammatory Properties 
- Helps Brain Health & Cognition 

This product is probably about as close as you can get to the niagen supplements, like Thorne ResveraCel, without actually containing niagen or using the patented process. Nicotinamide is a form of niacin easily processed by the body. And it contains bonus resveratrol. I've only been taking these two weeks, but I've found these supplements give me some mental boost/clarity and physical energy. My skin seems more elastic. I have less appetite (my usual tendency is to over eat) and sleep better. I've lost a couple of pounds. One side effect I get is upset stomach, but the seller/manufacturer claims this will go away with time. Overall, while these supplements are no "miracle cure," I think they are providing some benefit, and I will continue to take them. I'll reevaluate once I've made it through the first bottle.

TWO MONTH UPDATE: I still feel that I am benefiting from this product. Stomach upset has diminished. I have less joint pain. I have more energy and mental clarity. Better sleep. Skin feels younger. No additional weight loss.

4.5 out of 5 - 1,284 global ratings

4. Thorne Research ResveraCel

- Each capsule contains ChromaDex's proprietary Nicotinamide Riboside (NR) ingredient, Niagen, in addition to Resveratrol, Quercetin Phytosome, and Betaine. 
- The ingredients in this product are complexed with Time-Sorb, a time-release matrix.
- Supports healthy aging and helps regulate metabolism
- Resveratrol and quercetin increase the activity of sirtuins
- Betaine provides important methylation factors

- Flavors, colors, preservatives, and sweeteners derived from natural sources. 
- No gluten, Genetically Modified Organisms (known as GMOs), artificial preservatives, stearates, wheat, rye, barley, eggs, or nuts. This product does not contain dairy, soy, corn, yeast, sugar, or magnesium stearate.
- No unnecessary binders, coatings, disintegrants, fillers, or lubricants (including magnesium stearate) that could impair absorption.
- Adheres to the FDA’s current Good Manufacturing Practices (cGMPs) and has the highest number of NSF Certified for Sport products which tests for more than 200 banned substances for elite athletic competitions.

My husband and I are in our 60s and have been taking these capsules for a few weeks. We both started with 2 capsules daily and experienced an increase in energy and in focus. We also both had trouble remaining asleep at night and had strange dreams. We have decreased our consumption of the capsules to one per day and have had a resolution to the sleep problems. We both continue to enjoy an increase in energy and in focus. We have reordered this Thorne product and are very satisfied with the results. It would be best to start with one capsule per day and work up from there until you find your own correct dosage.

4.5 out of 5 - 1,282 global ratings

5. Nutricost Niacinamide

Niacinamide is a popular form of Vitamin B3, but without the often uncomfortable feeling known as "Niacin Flush". Vitamin B3 is most often found in meats like tuna and beef. However, in order to get a similar amount of Vitamin B3, you would have to eat large amounts of tuna and beef or other sources containing Vitamin B3.

- 240 Capsules of Niacinamide Per bottle / 1 Capsule per serving
- 500mg of Vitamin B3 (Niacinamide) Per Capsule
- No "Niacin Flush"
- Non-GMO, Gluten Free, Soy Free, and Made in a GMP Compliant, FDA Registered Facility

After a recent news article about this being a favorite supplement in Australia for sun damage protection, I asked my dermatologist about it. She said it might help prevent me getting as many 'barnacles' as she calls them. You know, those nasty, old-age, sun-damage, crunchy brown or white patches all over your body. (I have many). I'm still on my first bottle but after about two weeks the most amazing thing happened. I happened to scratch an area near one of my barnacles and it just flaked off in my hand. Since then, many more have succumbed. Not all; just some. But I'm happy. Even one less of those ugly bumps is an improvement.

4.6 out of 5 - 7,381 global ratings

6. NMN Max NAD+ Booster Supplements

-120 Tablets / 500 mg each Tablet/ 4 Months Supply
- Can be chewed or used sublingually (under the tongue). 
- Nicotinamide mononucleotide (NMN) is a derivative of the B-vitamin niacin that is known to promote health and longevity by serving as a precursor to NAD+. NAD+ is required for our longevity genes to work. 
- NMN Boosts Energy Metabolism; Promotes Healthy Brain Function; Anti-Aging & DNA Repair.
- Made without any chemical solvents, artificial ingredients, colors, preservatives or additives.
- Lozenges allow NMN to be absorbed directly into the blood vessels in the mouth and under the tongue, which can greatly increase the bioavailability of NMN and enhance the absorption of NMN in the blood.

Why Choose Sublingual NMN Lozenges?
* NMN Mood Enhancer
* NMN Help Weight Loss
* NMN Boost NAD+ Level
* NMN Energize Your Body
* Enhance Immune System
* NMN Promote Anti-Aging
* NMN Improve Sleep Quality
* Optimize Energy Metabolism
* Support Cardiovascular Health

I've been taking NMN for about six months. I can feel the difference - I have more energy, and when I exercise I build more muscle mass.

4.8 out of 5 - 180 global ratings

7. Komprocha NMN + Trans-Resveratrol

- Powerful Antioxidant & Anti-Aging Supplements for Heart, Immune & Skin Health

- Trans-Resveratrol (600mg) + NMN(500mg) +Black Pepper Extract (50mg)
- 60 capsules (Two daily)

- Komprocha NMN Trans-Resveratrol increases activity of the sirtuins – SIRT1 and SIRT3, in particular. In some study, resveratrol was shown to be the most potent natural activator of the sirtuins proteins. It has a positive effect on all three major longevity pathways.

- NMN nicotinamide mononucleotide is the direct precursor of NAD+ molecules, repair DNA and generate cell energy. 
- Taking NMN supplement will help to replenish NAD in the body. 
- Black pepper extract can effectively increase the bioavailability and increase the absorption rate of the main components. Enhanced absorption to slowing resveratrol breakdown.

- Third party lab tested for Trans-Resveratrol purity. And Our NMN Resveratrol Capsules comes in a completely shelf-stable non-refrigerated form, And the unique ENTERIC CAPSULE to highly reduce unnecessary component loss and ensure maximum absorption of NMN Resveratrol.

52 year old active male with weight lifting regularly for 20 years. My wife is 50. Day 3 and I started having flights of creative thought and exponential energy. My Focus was so strong I no longer needed breaks to keep going. Take in the morning on a empty stomach. Any drag by afternoon take an additional. I can only assume a complete cell reversal in 30 days for a healthier overall look.

My wife had been dealing with anxiety and it’s all gone. This might be one of the most significant additions to a health regiment.

If you are a male over 40 supplement with DHEA 50 - 100mg a day. DHEA is a precursor to testosterone. Combine NMN and those 2 for the ultimate feel good combo. I am lost for words on this breakthrough supplement.

4.8 out of 5 - 280 global ratings

8. Eco Cert NMN Plus

- Naturally Boost NAD+ Levels for Mental Performance & Anti Aging Supplement

- BOOST NAD+ LEVELS. Each time you take NMNPLUS, it will help replenish your body’s NAD.

- FULLY STABILIZED & ENHANCED ABSORPTION: Our NMN comes in a completely shelf-stable non-refrigerated form and is packaged and sold in opaque bottles and desiccant packs to protect it from light and moisture. 

- Unique ENTERIC CAPSULE to highly reduce unnecessary component loss and ensure maximum absorption of NMN.

- SLOWS AGING PROCESS. It can provide cellular energy optimization & health span support to enhance body functions and reduce disease risk. 

- Improves mood, support mental performance, and fight cognitive decline. 

- Take ONE capsule per day with food or a glass of water as you like. 

- Suitable for vegetarians and vegans, without traces of animal products. No GMO or Preservatives, No Artiļ¬cial Color, No Flavor or Sweetener, No Sugar, No Starch, No Milk, No Corn, No Soy, No Wheat, No Tree Nut, No Peanut, No Egg, No Lactose, No Gluten, No Yeast, No Fish, No Shellfish, No Sodium.

I loved the way it’s making me feel. I don’t feel sluggish and tired. I believe it’s replaced vitamins my body was lacking. I don’t eat many greens in my daily diet, and this definitely made my body improve. Because I felt more energetic I also moved around a lot more and felt like maybe I was losing some weight. I really like that I don’t get any nasty taste when burping either. It’s as if I didn’t take anything. I enjoy your products very much.

4.5 out of 5 - 824 global ratings



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