Hydroxychloroquine for COVID-19: Meta-analysis of 197 Studies (February 2021)

By Dr. Frank Yap, MD -

 At-A-Glance:

  • HCQ (Hydroxychloroquine) is not effective when used very late with high dosages over a long period (RECOVERY/SOLIDARITY), effectiveness improves with earlier usage and improved dosing. 
  • Early treatment consistently shows positive effects. 
  • Negative evaluations typically ignore treatment time, often focusing on a subset of late stage studies.

Introduction
We analyze all significant studies concerning the use of HCQ (or CQ) for COVID-19. Search methods, inclusion criteria, effect extraction criteria (more serious outcomes have priority), all individual study data, PRISMA answers, and statistical methods are detailed in Appendix 1. We present random-effects meta-analysis results for all studies, for studies within each treatment stage, for mortality results only, after exclusion of studies with critical bias, and for Randomized Controlled Trials (RCTs) only. Typical meta analyses involve subjective selection criteria and bias evaluation, requiring an understanding of the criteria and the accuracy of the evaluations. However, the volume of studies presents an opportunity for an additional simple and transparent analysis aimed at detecting efficacy.
If treatment was not effective, the observed effects would be randomly distributed (or more likely to be negative if treatment is harmful). We can compute the probability that the observed percentage of positive results (or higher) could occur due to chance with an ineffective treatment (the probability of >= k heads in n coin tosses, or the one-sided sign test / binomial test). Analysis of publication bias is important and adjustments may be needed if there is a bias toward publishing positive results. For HCQ, we find evidence of a bias toward publishing negative results.
Figure 2 shows stages of possible treatment for COVID-19. Pre-Exposure Prophylaxis (PrEP) refers to regularly taking medication before being infected, in order to prevent or minimize infection. In Post-Exposure Prophylaxis (PEP), medication is taken after exposure but before symptoms appear. Early Treatment refers to treatment immediately or soon after symptoms appear, while Late Treatment refers to more delayed treatment.
Results
Early treatment.
 100% of early treatment studies report a positive effect, with an estimated reduction of 66% in the effect measured (death, hospitalization, etc.) from the random effects meta-analysis, RR 0.34 [0.27-0.44].
Late treatment.
 Late treatment studies are mixed, with 73% showing positive effects, and an estimated reduction of 25% in the random effects meta-analysis. Negative studies mostly fall into the following categories: they show evidence of significant unadjusted confounding, including confounding by indication; usage is extremely late; or they use an excessively high dosage.
Pre-Exposure Prophylaxis.
 77% of PrEP studies show positive effects, with an estimated reduction of 36% in the random effects meta-analysis. Negative studies are all studies of systemic autoimmune disease patients which either do not adjust for the different baseline risk of these patients at all, or do not adjust for the highly variable risk within these patients.
Post-Exposure Prophylaxis.
 83% of PEP studies report positive effects, with an estimated reduction of 33% in the random effects meta-analysis.
Results by treatment stage


Randomized Controlled Trials (RCTs)
Randomized Controlled Trials (RCTs) minimize one source of bias and can provide a higher level of evidence. Results restricted to RCTs are shown in Figure 7, Figure 8, and Table 2. Even with the small number of RCTs to date, they confirm efficacy for early treatment. Prophylaxis and early treatment studies show 29% improvement in random effects meta-analysis, RR 0.71 [0.54‑0.94], p = 0.015. Early treatment RCTs show 49% improvement, RR 0.51 [0.30‑0.88], p = 0.015.
Evidence supports incorporating non-RCT studies. [Concato] find that well-designed observational studies do not systematically overestimate the magnitude of the effects of treatment compared to RCTs. [Anglemyer] summarized reviews comparing RCTs to observational studies and found little evidence for significant differences in effect estimates. [Lee] shows that only 14% of the guidelines of the Infectious Diseases Society of America were based on RCTs. Limitations in an RCT can easily outweigh the benefits, for example excessive dosages, excessive treatment delays, or Internet survey bias could easily have a greater effect on results. Ethical issues may prevent running RCTs for known effective treatments. For more on the problems with RCTs see [Deaton, Nichol].
Discussion
Publication bias.
 Publishing is often biased towards positive results, which we would need to adjust for when analyzing the percentage of positive results. Studies that require less effort are considered to be more susceptible to publication bias. Prospective trials that involve significant effort are likely to be published regardless of the result, while retrospective studies are more likely to exhibit bias. For example, researchers may perform preliminary analysis with minimal effort and the results may influence their decision to continue. Retrospective studies also provide more opportunities for the specifics of data extraction and adjustments to influence results.
For HCQ, 87.8% of prospective studies report positive effects, compared to 75.0% of retrospective studies, indicating a bias toward publishing negative results. Figure 10 shows a scatter plot of results for prospective and retrospective studies.
Figure 11 shows the results by region of the world, for all regions that have > 5 studies. Studies from North America are 3.8 times more likely to report negative results than studies from the rest of the world combined, 52.3% vs. 13.7%, two-tailed z test -5.36, p = 0.00000008. [Berry] performed an independent analysis which also showed bias toward negative results for US-based research.
The lack of bias towards positive results is not very surprising. Both negative and positive results are very important given the current use of HCQ for COVID-19 around the world, evidence of which can be found in the studies analyzed here, government protocols, and news reports, for example [AFP, AfricaFeeds, Africanews, Afrik.com, Al Arabia, Al-bab, Anadolu Agency, Anadolu Agency (B), Archyde, Barron's, Barron's (B), BBC, Belayneh, A., Bianet, CBS News, Challenge, Dr. Goldin, Efecto Cocuyo, Expats.cz, Face 2 Face Africa, Filipova, France 24, France 24 (B), Franceinfo, Global Times, Government of China, Government of India, Government of Venezuela, GulfInsider, Le Nouvel Afrik, LifeSiteNews, Medical World Nigeria, Medical Xpress, Medical Xpress (B), Middle East Eye, Ministerstva Zdravotnictví, Ministry of Health of Ukraine, Ministry of Health of Ukraine (B), Morocco World News, Mosaique Guinee, Nigeria News World, NPR News, Oneindia, Pan African Medical Journal, Parola, Pilot News, PledgeTimes, Pleno.News, Q Costa Rica, Rathi, Russian Government, Russian Government (B), Teller Report, The Africa Report, The Australian, The BL, The East African, The Guardian, The Indian Express, The Moscow Times, The North Africa Post, The Tico Times, Ukrinform, Vanguard, Voice of America].
We also note a bias towards publishing negative results by certain journals and press organizations, with scientists reporting difficulty publishing positive results [Boulware, Meneguesso]. Although 153 studies show positive results, The New York Times, for example, has only written articles for studies that claim HCQ is not effective [The New York Times, The New York Times (B), The New York Times (C)]. As of September 10, 2020, The New York Times still claims that there is clear evidence that HCQ is not effective for COVID-19 [The New York Times (D)]. As of October 9, 2020, the United States National Institutes of Health recommends against HCQ for both hospitalized and non-hospitalized patients [United States National Institutes of Health].
Treatment details.
 We focus here on the question of whether HCQ is effective or not for COVID-19. Studies vary significantly in terms of treatment delay, treatment regimen, patients characteristics, and (for the pooled effects analysis) outcomes, as reflected in the high degree of heterogeneity. However, early treatment consistently shows benefits. 100% of early treatment studies report a positive effect, with an estimated reduction of 66% in the effect measured (death, hospitalization, etc.) in the random effects meta-analysis, RR 0.34 [0.27-0.44].
Conclusion
HCQ is an effective treatment for COVID-19. The probability that an ineffective treatment generated results as positive as the 197 studies to date is estimated to be 1 in 768 trillion (p = 0.0000000000000013).
100% of early treatment studies report a positive effect, with an estimated reduction of 66% in the effect measured (death, hospitalization, etc.) using a random effects meta-analysis, RR 0.34 [0.27-0.44].

Appendix 1. Methods and Study Results
We performed ongoing searches of PubMed, medRxiv, ClinicalTrials.gov, The Cochrane Library, Google Scholar, Collabovid, Research Square, ScienceDirect, Oxford University Press, the reference lists of other studies and meta-analyses, and submissions to the site c19study.com, which regularly receives submissions of both positive and negative studies upon publication. Search terms were hydroxychloroquine or chloroquine and COVID-19 or SARS-CoV-2, or simply hydroxychloroquine or chloroquine. Automated searches are performed every hour with notifications of new matches. All studies regarding the use of HCQ or CQ for COVID-19 that report an effect compared to a control group are included in the main analysis. This is a living analysis and is updated regularly.
We extracted effect sizes and associated data from all studies. If studies report multiple kinds of effects then the most serious outcome is used in calculations for that study. For example, if effects for mortality and cases are both reported, the effect for mortality is used, this may be different to the effect that a study focused on. If symptomatic results are reported at multiple times, we used the latest time, for example if mortality results are provided at 14 days and 28 days, the results at 28 days are used. Mortality alone is preferred over combined outcomes. Outcomes with zero events in both arms were not used. Clinical outcome is considered more important than PCR testing status. For PCR results reported at multiple times, where a majority of patients recover in both groups, preference is given to results mid-recovery (after most or all patients have recovered there is no room for an effective treatment to do better). When results provide an odds ratio, we computed the relative risk when possible, or converted to a relative risk according to [Zhang]. Reported confidence intervals and p-values were used when available, using adjusted values when provided. If multiple types of adjustments are reported including propensity score matching (PSM), the PSM results are used. When needed, conversion between reported p-values and confidence intervals followed [Altman, Altman (B)], and Fisher's exact test was used to calculate p-values for event data. If continuity correction for zero values is required, we use the reciprocal of the opposite arm with the sum of the correction factors equal to 1 [Sweeting]. If a study separates HCQ and HCQ+AZ, we use the combined results were possible, or the results for the larger group. Results are all expressed with RR < 1.0 suggesting effectiveness. Most results are the relative risk of something negative. If a study reports relative times, the results are expressed as the ratio of the time for the HCQ group versus the time for the control group. If a study reports the rate of reduction of viral load, the results are based on the percentage change in the rate. Calculations are done in Python (3.9.1) with scipy (1.5.4), pythonmeta (1.11), numpy (1.19.4), statsmodels (0.12.1), and plotly (4.14.1).
The forest plots are computed using PythonMeta [Deng] with the DerSimonian and Laird random effects model (the fixed effect assumption is not plausible in this case).
We received no funding, this research is done in our spare time. We have no affiliations with any pharmaceutical companies or political parties.
We have classified studies as early treatment if most patients are not already at a severe stage at the time of treatment, and treatment started within 5 days after the onset of symptoms, although a shorter time may be preferable. Antivirals are typically only considered effective when used within a shorter timeframe, for example 0-36 or 0-48 hours for oseltamivir, with longer delays not being effective [McLean, Treanor].
References
2.
Abdulrahman et al., medRxiv, doi:10.1101/2020.11.25.20234914, The efficacy and safety of hydroxychloroquine in COVID19 patients : a multicenter national retrospective cohort , https://www.medrxiv.org/content/10.1101/2020.11.25.20234914v1.
3.
Abella et al., JAMA Internal Medicine, doi:doi:10.1001/jamainternmed.2020.6319, Efficacy and Safety of Hydroxychloroquine vs Placebo for Pre-exposure SARS-CoV-2 Prophylaxis Among Health Care Workers, https://jamanetwork.com/journals/j..ternalmedicine/fullarticle/2771265.
5.
AFP, India backs hydroxychloroquine for virus prevention, https://www.msn.com/en-ph/news/wor..us-prevention/ar-BB14EloP?ocid=st2.
6.
AfricaFeeds, Kenya approve the use of Chloroquine to treat COVID-19 patients, https://africafeeds.com/2020/04/01..oquine-to-treat-covid-19-patients/.
7.
Africanews, Coronavirus patients on chloroquine heal faster - Senegalese medic, https://www.africanews.com/2020/04..uine-heal-faster-senegalese-medic/.
8.
Afrik.com, Edouard Philippe emporté par le Covid, Didier Raoult, l’hydroxychloroquine et le… remdésivir, https://www.afrik.com/edouard-phil..ydroxychloroquine-et-le-remdesivir.
9.
Águila-Gordo et al., Revista Española de Geriatría y Gerontología, doi:10.1016/j.regg.2020.09.006, Mortality and associated prognostic factors in elderly and very elderly hospitalized patients with respiratory disease COVID-19, https://www.sciencedirect.com/science/article/pii/S0211139X20301748.
10.
Agusti et al., Enfermedades Infecciosas y Microbiología Clínica, doi:10.1016/j.eimc.2020.10.023, Efficacy and safety of hydroxychloroquine in healthcare professionals with mild SARS-CoV-2 infection: prospective, non-randomized trial, https://www.sciencedirect.com/scie../article/abs/pii/S0213005X20304134.
11.
Al Arabia, Bahrain among first countries to use Hydroxychloroquine to treat coronavirus, https://english.alarabiya.net/en/N..xychloroquine-to-treat-coronavirus.
12.
Al-bab, Covid-19: Algeria and Morocco continue using chloroquine despite concerns, https://al-bab.com/blog/2020/05/co..using-chloroquine-despite-concerns.
14.
Alberici et al., Kidney Int., 98:1, 20-26, July 1, 2020, doi:10.1016/j.kint.2020.04.030 (preprint 5/10), A report from the Brescia Renal COVID Task Force on the clinical characteristics and short-term outcome of hemodialysis patients with SARS-CoV-2 infection, https://www.kidney-international.o..cle/S0085-2538(20)30508-1/fulltext.
15.
Almazrou et al., Saudi Pharmaceutical Journal, doi:10.1016/j.jsps.2020.09.019, Comparing the impact of Hydroxychloroquine based regimens and standard treatment on COVID-19 patient outcomes: A retrospective cohort study, https://www.sciencedirect.com/science/article/pii/S1319016420302334.
16.
Alqassieh et al., F1000Research, Preprint, Clinical characteristics and predictors of the duration of hospital stay in COVID-19 patients in Jordan, https://f1000research.com/articles/9-1439.
17.
Altman, D., BMJ, doi:10.1136/bmj.d2304, How to obtain the P value from a confidence interval, https://www.bmj.com/content/343/bmj.d2304.
19.
An et al., medRxiv, doi:10.1101/2020.07.04.20146548, Treatment Response to Hydroxychloroquine and Antibiotics for mild to moderate COVID-19: a retrospective cohort study from South Korea, https://www.medrxiv.org/content/10.1101/2020.07.04.20146548v1.
20.
Anadolu Agency, Nigeria goes on with hydroxychloroquine clinical trial, https://www.aa.com.tr/en/africa/ni..hloroquine-clinical-trials/1854814.
21.
Anadolu Agency (B), Cuba: Early hydroxychloroquine potent against COVID-19, https://www.aa.com.tr/en/americas/..ne-potent-against-covid-19/1905650.
23.
Annie et al., Pharmacotherapy, doi:10.1002/phar.2467, Hydroxychloroquine in hospitalized COVID‐19 patients: Real world experience assessing mortality, https://accpjournals.onlinelibrary.wiley.com/doi/10.1002/phar.2467.
24.
Aparisi et al., medRxiv, doi:10.1101/2020.10.06.20207092, Low-density lipoprotein cholesterol levels are associated with poor clinical outcomes in COVID-19, https://www.medrxiv.org/content/10.1101/2020.10.06.20207092v1.
25.
Archyde, China approves chloroquine (instead of hydroxychloroquine) against covid-19, https://www.archyde.com/china-appr..droxychloroquine-against-covid-19/.
26.
Arleo et al., medRxiv, doi:10.1101/2020.10.26.20219154, Clinical Course and Outcomes of coronavirus disease 2019 (COVID-19) in Rheumatic Disease Patients on Immunosuppression: A case Cohort Study at a Single Center with a Significantly Diverse Population, https://www.medrxiv.org/content/10.1101/2020.10.26.20219154v1.
27.
Arshad et al., Int. J. Infect. Dis., July 1 2020, doi:10.1016/j.ijid.2020.06.099, Treatment with Hydroxychloroquine, Azithromycin, and Combination in Patients Hospitalized with COVID-19, https://www.ijidonline.com/article/S1201-9712(20)30534-8/fulltext.
28.
Ashinyo et al., Pan African Medical Journal, 37:1, doi:10.11604/pamj.supp.2020.37.1.25718, Clinical characteristics, treatment regimen and duration of hospitalization among COVID-19 patients in Ghana: a retrospective cohort study, https://www.panafrican-med-journal.com/content/series/37/1/9/full/.
29.
Ashraf et al., medRxiv doi:10.1101/2020.04.20.20072421.t, COVID-19 in Iran, a comprehensive investigation from exposure to treatment outcomes, https://www.researchgate.net/publi..rom_exposure_to_treatment_outcomes.
31.
Axfors et al., medRxiv, doi:10.1101/2020.09.16.20194571, Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19: an international collaborative meta-analysis of randomized trials, https://www.medrxiv.org/content/10.1101/2020.09.16.20194571v1.
32.
Ayerbe et al., Internal and Emergency Medicine, doi:0.1007/s11739-020-02505-x, The association of treatment with hydroxychloroquine and hospital mortality in COVID-19 patients, https://link.springer.com/article/10.1007/s11739-020-02505-x.
33.
Barbosa et al., Preprint, Clinical outcomes of hydroxychloroquine in hospitalized patients with COVID-19: a quasi-randomized comparative study, https://www.sefq.es/_pdfs/NEJM_Hydroxychlorquine.pdf.
34.
Barnabas et al., Annals of Internal Medicine, doi:10.7326/M20-6519, Hydroxychloroquine for Post-exposure Prophylaxis to Prevent Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Randomized Trial, https://www.acpjournals.org/doi/10.7326/M20-6519.
36.
Barron's (B), Amid Global Controversy, Greece Moves Forward With Chloroquine, https://www.barrons.com/news/amid-..rward-with-chloroquine-01591781707.
37.
BBC, Coronavirus: How Turkey took control of Covid-19 emergency, https://www.bbc.com/news/world-europe-52831017.
38.
Behera et al., medRxiv, doi:10.1101/2020.10.29.20222661v1, Role of ivermectin in the prevention of COVID-19 infection among healthcare workers in India: A matched case-control study, https://www.medrxiv.org/content/10.1101/2020.10.29.20222661v1.
39.
Belayneh, A., Off-Label Use of Chloroquine and Hydroxychloroquine for COVID-19 Treatment in Africa Against WHO Recommendation, https://www.dovepress.com/off-labe..eer-reviewed-fulltext-article-RRTM.
40.
Berenguer et al., Clinical Microbiology and Infection, doi:10.1016/j.cmi.2020.07.024, Characteristics and predictors of death among 4035 consecutively hospitalized patients with COVID-19 in Spain, https://www.clinicalmicrobiologyan..cle/S1198-743X(20)30431-6/fulltext.
42.
Bernaola et al., medRxiv, doi:10.1101/2020.07.17.20155960, Observational Study of the Efficiency of Treatments in Patients Hospitalized with Covid-19 in Madrid, https://www.medrxiv.org/content/10.1101/2020.07.17.20155960v1.
43.
Berry et al., SSRN, Berry, doi:10.2139/ssrn.3707327., Unfavorable Hydroxychloroquine COVID-19 Research Associated with Authors Having a History of Political Party Donations, https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3707327.
44.
Bhattacharya et al., medRxix, doi:10.1101/2020.06.09.20116806, Pre exposure Hydroxychloroquine use is associated with reduced COVID19 risk in healthcare workers, https://www.medrxiv.org/content/10.1101/2020.06.09.20116806v1.
45.
Bianet, Turkey begins distributing hydroxychloroquine to homes in capital city amid bed shortage, https://bianet.org/english/health/..-in-capital-city-amid-bed-shortage.
46.
Bielza et al., Journal of the American Medical Directors Association, doi:10.1016/j.jamda.2020.12.003, Clinical characteristics, frailty and mortality of residents with COVID-19 in nursing homes of a region of Madrid, https://www.sciencedirect.com/science/article/pii/S1525861020310525.
47.
Boari et al, Biosci. Rep., doi:10.1042/BSR20203455, Prognostic factors and predictors of outcome in patients with COVID-19 and related pneumonia: a retrospective cohort study, https://portlandpress.com/bioscire..cle/doi/10.1042/BSR20203455/226985.
48.
Borba et al., JAMA Network Open, doi:10.1001/jamanetworkopen.2020.8857, Chloroquine diphosphate in two different dosages as adjunctive therapy of hospitalized patients with severe respiratory syndrome in the context of coronavirus (SARS-CoV-2) infection: Preliminary safety results of a randomized, double-blinded, phase IIb clinical trial (CloroCovid-19 Study), https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2765499.
50.
Boulware (B) et al., NEJM, June 3 2020, doi:10.1056/NEJMoa2016638, A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19, https://www.nejm.org/doi/full/10.1056/NEJMoa2016638.
51.
Bousquet et al., Aging, 12:12, 11306-11313, doi:10.18632/aging.103583, ADL-dependency, D-Dimers, LDH and absence of anticoagulation are independently associated with one-month mortality in older inpatients with Covid-19, https://www.aging-us.com/article/103583/text.
52.
Budhiraja et al., medRxiv, doi:10.1101/2020.11.16.20232223, Clinical Profile of First 1000 COVID-19 Cases Admitted at Tertiary Care Hospitals and the Correlates of their Mortality: An Indian Experience, https://www.medrxiv.org/content/10.1101/2020.11.16.20232223v1.
53.
Cadegiani et al., medRxiv, doi:10.1101/2020.10.31.20223883, Early COVID-19 Therapy with Azithromycin Plus Nitazoxanide, Ivermectin or Hydroxychloroquine in Outpatient Settings Significantly Reduced Symptoms Compared to Known Outcomes in Untreated Patients, https://www.medrxiv.org/content/10.1101/2020.10.31.20223883v1.
54.
Cangiano et al., Aging, doi:10.18632/aging.202307, Mortality in an Italian nursing home during COVID-19 pandemic: correlation with gender, age, ADL, vitamin D supplementation, and limitations of the diagnostic tests, https://www.aging-us.com/article/202307/text.
55.
Capsoni et al., Research Square, doi:10.21203/rs.3.rs-113418/v1, CPAP Treatment In COVID-19 Patients: A Retrospective Observational Study In The Emergency Department, https://www.researchsquare.com/article/rs-113418/v1.
56.
Cassione et al., Annals of the Rheumatic Diseases, doi:10.1136/annrheumdis-2020-217717, COVID-19 infection in a northern-Italian cohort of systemic lupus erythematosus assessed by telemedicine, https://ard.bmj.com/content/early/..05/23/annrheumdis-2020-217717.info.
57.
Catteau et al., Int. J. Antimicrobial Agents, doi:10.1016/j.ijantimicag.2020.106144, Low-dose Hydroxychloroquine Therapy and Mortality in Hospitalized Patients with COVID-19: A Nationwide Observational Study of 8075 Participants, https://www.sciencedirect.com/scie../article/abs/pii/S0924857920303423.
58.
Cavalcanti et al., NEJM, July 23, 2020, doi:10.1056/NEJMoa2019014, Hydroxychloroquine with or without Azithromycin in Mild-to-Moderate Covid-19, https://www.nejm.org/doi/full/10.1056/NEJMoa2019014.
59.
CBS News, Turkey claims success treating virus with drug touted by Trump, https://www.msn.com/en-au/news/wor..h-drug-touted-by-trump/ar-BB13oMXS.
61.
Chari et al., Blood, doi:10.1182/blood.2020008150, Clinical features associated with COVID-19 outcome in multiple myeloma: first results from the International Myeloma Society data set, https://www.sciencedirect.com/science/article/pii/S0006497120839044.
62.
Chatterjee et al., Indian J. Med. Res., June 20, 2020, doi:10.4103/ijmr.IJMR_2234_20, Healthcare workers & SARS-CoV-2 infection in India: A case-control investigation in the time of COVID-19, https://www.ijmr.org.in/article.as..ge=459;epage=467;aulast=Chatterjee.
63.
Chen et al., medRxiv, doi:10.1101/2020.06.19.20136093, Efficacy and safety of chloroquine or hydroxychloroquine in moderate type of COVID-19: a prospective open-label randomized controlled study, https://www.medrxiv.org/content/10.1101/2020.06.19.20136093v1.
64.
Chen (B) et al., PLOS ONE, doi:10.1371/journal.pone.0242763, A Multicenter, randomized, open-label, controlled trial to evaluate the efficacy and tolerability of hydroxychloroquine and a retrospective study in adult patients with mild to moderate Coronavirus disease 2019 (COVID-19), https://journals.plos.org/plosone/..le?id=10.1371/journal.pone.0242763.
65.
Chen (C) et al., PLOS ONE, doi:10.1371/journal.pone.0242763, A Multicenter, randomized, open-label, controlled trial to evaluate the efficacy and tolerability of hydroxychloroquine and a retrospective study in adult patients with mild to moderate Coronavirus disease 2019 (COVID-19), https://journals.plos.org/plosone/..le?id=10.1371/journal.pone.0242763.
66.
Chen (D) et al., medRxiv doi:10.1101/2020.03.22.20040758, Efficacy of hydroxychloroquine in patients with COVID-19: results of a randomized clinical trial, https://www.medrxiv.org/content/10.1101/2020.03.22.20040758v3.
67.
Chen (E) et al., J. Zhejiang University (Med Sci), doi:10.3785/j.issn.1008-9292.2020.03.03, A pilot study of hydroxychloroquine in treatment of patients with common coronavirus disease-19 (COVID-19), http://www.zjujournals.com/med/EN/..cleFile.do?attachType=PDF&id=41137.
68.
Choi et al., International Journal of Infectious Diseases, doi:10.1016/j.ijid.2020.10.062, Comparison of antiviral effect for mild-to-moderate COVID-19 cases between lopinavir/ritonavir versus hydroxychloroquine: A nationwide propensity score-matched cohort study, https://www.sciencedirect.com/science/article/pii/S1201971220322669.
71.
Cordtz et al., Rheumatology, doi:10.1093/rheumatology/keaa897, Incidence and severeness of COVID-19 hospitalisation in patients with inflammatory rheumatic disease: a nationwide cohort study from Denmark, https://academic.oup.com/rheumatol...1093/rheumatology/keaa897/6053804.
72.
Cravedi et al., American Journal of Transplantation, doi:10.1111/ajt.16185, COVID‐19 and kidney transplantation: Results from the TANGO International Transplant Consortium, https://onlinelibrary.wiley.com/doi/full/10.1111/ajt.16185.
74.
Davido et al., Int. J. Antimicrobial Agents, 2020, doi:10.1016/j.ijantimicag.2020.106129, Impact of medical care including anti-infective agents use on the prognosis of COVID-19 hospitalized patients over time, https://www.sciencedirect.com/science/article/pii/S0924857920303125.
77.
Deng, H., PyMeta, Python module for meta-analysis, http://www.pymeta.com/.
78.
Derwand et al., International Journal of Antimicrobial Agents, doi:10.1016/j.ijantimicag.2020.106214 (preprint 7/3), COVID-19 Outpatients – Early Risk-Stratified Treatment with Zinc Plus Low Dose Hydroxychloroquine and Azithromycin: A Retrospective Case Series Study, https://www.sciencedirect.com/science/article/pii/S0924857920304258.
79.
Desbois et al., Research Square, doi:10.21203/rs.3.rs-41653/v1, Prevalence and clinical features of COVID-19 in a large cohort of 199 patients with sarcoidosis, https://www.researchsquare.com/article/rs-41653/v1.
80.
Dhibar et al., International Journal of Antimicrobial Agents, doi:10.1016/j.ijantimicag.2020.106224, Post Exposure Prophylaxis with Hydroxychloroquine (HCQ) for the Prevention of COVID-19, a Myth or a Reality? The PEP-CQ Study, https://www.sciencedirect.com/science/article/pii/S0924857920304350.
81.
Di Castelnuovo et al., European J. Internal Medicine, doi:10.1016/j.ejim.2020.08.019, Use of hydroxychloroquine in hospitalised COVID-19 patients is associated with reduced mortality: Findings from the observational multicentre Italian CORIST study, https://www.sciencedirect.com/scie../article/abs/pii/S0953620520303356.
82.
Dr. Goldin, Summary of HCQ usage in India from an MD in India, https://www.facebook.com/groups/hy..oquine/permalink/2367454293560817/.
83.
Dubee et al., medRxiv, doi:10.1101/2020.10.19.20214940, A placebo-controlled double blind trial of hydroxychloroquine in mild-to-moderate COVID-19, https://www.medrxiv.org/content/10.1101/2020.10.19.20214940v1.
84.
Dubernet et al., J. Global Antimicrobial Resistance, doi:10.1016/j.jgar.2020.08.001, A comprehensive strategy for the early treatment of COVID-19 with azithromycin/hydroxychloroquine and/or corticosteroids: results of a retrospective observational study in the French overseas department of Reunion Island, https://www.sciencedirect.com/science/article/pii/S221371652030206X.
85.
Efecto Cocuyo, Venezuela empieza a usar la cloroquina para tratar COVID-19, anuncia Jorge Rodríguez, https://efectococuyo.com/coronavir..-covid-19-anuncia-jorge-rodriguez/.
86.
Esper et al., Prevent Senior Institute, São Paulo, Brazil, Empirical treatment with hydroxychloroquine and azithromycin for suspected cases of COVID-19 followed-up by telemedicine, https://www.dropbox.com/s/5qm58cd4..20journal%20manuscript%20final.pdf.
87.
Expats.cz, Czech Health Ministry permits temporary use of hydroxychloroquine to treat COVID-19, https://news.expats.cz/weekly-czec..ne-in-hospitals-to-treat-covid-19/.
88.
Face 2 Face Africa, Djibouti, others warned about chloroquine despite big COVID-19 recoveries, https://face2faceafrica.com/articl..ne-despite-big-covid-19-recoveries.
89.
Faíco-Filho et al., Braz J Microbiol, doi:10.1007/s42770-020-00395-x (preprint 6/21), No benefit of hydroxychloroquine on SARS-CoV-2 viral load reduction in non-critical hospitalized patients with COVID-19, https://link.springer.com/article/10.1007/s42770-020-00395-x.
90.
Falcone et al., Open Forum Infectious Diseases, doi:10.1093/ofid/ofaa563, Role of low-molecular weight heparin in hospitalized patients with SARS-CoV-2 pneumonia: a prospective observational study, https://academic.oup.com/ofid/adva..e/doi/10.1093/ofid/ofaa563/5992463.
92.
Ferri at al., Clinical Rheumatology, doi:0.1007/s10067-020-05334-7, COVID-19 and rheumatic autoimmune systemic diseases: report of a large Italian patients series, https://link.springer.com/article/10.1007/s10067-020-05334-7.
93.
Filipova et al., Health Science Journal, Is there a Correlation between Changes in Hydroxychloroquine Use and Mortality Rates from COVID-19?, https://www.hsj.gr/medicine/is-the..nd-mortalityrates-from-covid19.pdf.
94.
Fonseca et al., Travel Medicine and Infectious Disease, doi:10.1016/j.tmaid.2020.101906, Risk of Hospitalization for Covid-19 Outpatients Treated with Various Drug Regimens in Brazil: Comparative Analysis, https://www.sciencedirect.com/scie../article/abs/pii/S1477893920304026.
95.
Fontana et al., Clinical Kidney Journal, 13:3, 334–339, doi:10.1093/ckj/sfaa084, SARS-CoV-2 infection in dialysis patients in northern Italy: a single-centre experience, https://academic.oup.com/ckj/article/13/3/334/5860798.
96.
France 24, Covid-19: In Cameroon, chloroquine therapy hailed by French expert becomes state protocol, https://www.france24.com/en/202005..ench-expert-becomes-state-protocol.
97.
France 24 (B), Covid-19 : au Cameroun, la méthode Raoult érigée en protocole d'État, https://www.france24.com/fr/202005..ig%C3%A9e-en-protocole-d-%C3%A9tat.
98.
Franceinfo, Ces pays africains qui ont décidé de continuer à soigner le Covid-19 avec l'hydroxychloroquine, https://www.francetvinfo.fr/monde/..-l-hydroxychloroquine_3983239.html.
99.
Fried et al., Clinical Infectious Disease, doi:10.1093/cid/ciaa1268, Patient Characteristics and Outcomes of 11,721 Patients with COVID19 Hospitalized Across the United States, https://academic.oup.com/cid/advan..e/doi/10.1093/cid/ciaa1268/5898276.
100.
Frontera et al., Research Square, doi:10.21203/rs.3.rs-94509/v1, Treatment with Zinc is Associated with Reduced In-Hospital Mortality Among COVID-19 Patients: A Multi-Center Cohort Study, https://www.researchsquare.com/article/rs-94509/v1.
101.
Garcia-Albeniz et al., medRxiv, doi:10.1101/2020.09.29.20203869, Brief communication: A meta-analysis of randomized trials of hydroxychloroquine for the prevention of COVID-19, https://www.medrxiv.org/content/10.1101/2020.09.29.20203869v2.
102.
Gautret et al., Int. J. of Antimicrobial Agents, doi:10.1016/j.ijantimicag.2020.105949 (preprint 3/17), Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial, https://www.sciencedirect.com/scie../article/abs/pii/S0924857920300996.
103.
Geleris et al., NEJM, May 7, 2020, doi:10.1056/NEJMoa2012410, Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19, https://www.nejm.org/doi/full/10.1056/NEJMoa2012410.
104.
Gendebien et al., Annals of the Rheumatic Diseases, doi:10.1136/annrheumdis-2020-218244, Systematic analysis of COVID-19 infection and symptoms in a systemic lupus erythematosus population: correlation with disease characteristics, hydroxychloroquine use and immunosuppressive treatments, https://ard.bmj.com/content/early/2020/06/25/annrheumdis-2020-218244.
105.
Gendelman et al., Autoimmunity Reviews, 19:7, July 2020, doi:10.1016/j.autrev.2020.102566, Continuous Hydroxychloroquine or Colchicine Therapy Does Not Prevent Infection With SARS-CoV-2: Insights From a Large Healthcare Database Analysis, https://www.sciencedirect.com/science/article/pii/S1568997220301282.
106.
Gentry et al., Lancet Rheumatology, doi:10.1016/S2665-9913(20)30305-2, Long-term hydroxychloroquine use in patients with rheumatic conditions and development of SARS-CoV-2 infection: a retrospective cohort study, https://www.thelancet.com/journals../PIIS2665-9913(20)30305-2/fulltext.
107.
Gianfrancesco et al., Annals of the Rheumatic Diseases, 79:7, 859-866, doi:10.1136/annrheumdis-2020-217871, Characteristics associated with hospitalisation for COVID-19 in people with rheumatic disease: data from the COVID-19 Global Rheumatology Alliance physician-reported registry, https://europepmc.org/article/med/32471903.
108.
Global Times, Chinese medical expert decorated by Djibouti for COVID-19 prevention, https://www.globaltimes.cn/content/1189839.shtml.
109.
Goenka et al., SSRN, doi:10.2139/ssrn.3689618, Seroprevalence of COVID-19 Amongst Health Care Workers in a Tertiary Care Hospital of a Metropolitan City from India, https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3689618.
110.
Goldman et al., NEJM, doi:10.1056/NEJMoa2015301, Remdesivir for 5 or 10 Days in Patients with Severe Covid-19, https://www.nejm.org/doi/10.1056/NEJMoa2015301.
111.
Gönenli et al., Research Square, doi:0.21203/rs.3.rs-107937/v1, Prophylactic use of Hydroxychloroquine among Physicians working in Pandemic Hospitals, https://www.researchsquare.com/article/rs-107937/v1.
112.
Gonzalez et al., medRxiv, doi:10.1101/2020.08.18.20172874, The Prognostic Value of Eosinophil Recovery in COVID-19: A Multicentre, Retrospective Cohort Study on Patients Hospitalised in Spanish Hospitals, https://www.medrxiv.org/content/10.1101/2020.08.18.20172874v1.
113.
Government of China, 关于印发新型冠状病毒肺炎诊疗方案（试行第八版）的通知, http://www.nhc.gov.cn/yzygj/s7653p..df12bd4b46e5bd28ca7f9a7f5e5a.shtml.
114.
Government of India, The caregiver and all close contacts of such cases should take HCQ prophylaxis, https://www.mohfw.gov.in/pdf/RevisedHomeIsolationGuidelines.pdf.
115.
Government of Venezuela, THERAPEUTIC MANAGEMENT GUIDE FOR COVID-19 PATIENTS AND CONTACTS, http://www.mpps.gob.ve/index.php/sistemas/descargas.
116.
Grau-Pujol et al., Research Square, doi:10.21203/rs.3.rs-72132/v1, Pre-exposure prophylaxis with hydroxychloroquine for COVID-19: initial results of a double-blind, placebo-controlled randomized clinical trial, https://www.researchsquare.com/article/rs-72132/v1.
119.
Guisado-Vasco, Clinical characteristics and outcomes among hospitalized adults with severe COVID-19 admitted to a tertiary medical center and receiving antiviral, antimalarials, glucocorticoids, or immunomodulation with tocilizumab or cyclosporine: A retrospective observational study (COQUIMA cohort), https://www.sciencedirect.com/science/article/pii/S2589537020303357.
120.
Guisado-Vasco (B), Clinical characteristics and outcomes among hospitalized adults with severe COVID-19 admitted to a tertiary medical center and receiving antiviral, antimalarials, glucocorticoids, or immunomodulation with tocilizumab or cyclosporine: A retrospective observational study (COQUIMA cohort), https://www.sciencedirect.com/science/article/pii/S2589537020303357.
121.
GulfInsider, Coronavirus: Bahrain’s Therapeutic Medication Proved Effective, https://www.gulf-insider.com/coron..eutic-medication-proved-effective/.
122.
Güner et al., Journal of Infection and Public Health, doi:10.1016/j.jiph.2020.12.017, Comparing ICU Admission Rates of Mild/Moderate COVID-19 Patients Treated with Hydroxychloroquine, Favipiravir, and Hydroxychloroquine plus Favipiravir, https://www.sciencedirect.com/science/article/pii/S1876034120307735.
123.
Gupta et al., JAMA Intern. Med., doi:10.1001/jamainternmed.2020.3596, Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US, https://jamanetwork.com/journals/j..ternalmedicine/fullarticle/2768602.
124.
Heberto et al., IJC Heart & Vasculature, doi:10.1016/j.ijcha.2020.100638, Implications of myocardial injury in Mexican hospitalized patients with coronavirus disease 2019 (COVID-19), https://www.sciencedirect.com/science/article/pii/S2352906720303365.
126.
Hong et al., Infect. Chemother., 2020, doi:10.3947/ic.2020.52.e43, Early Hydroxychloroquine Administration for Rapid Severe Acute Respiratory Syndrome Coronavirus 2 Eradication, https://icjournal.org/DOIx.php?id=10.3947/ic.2020.52.3.396.
127.
Huang et al., Annals of the Rheumatic Diseases 2020:79, 1163-1169, doi:10.1136/annrheumdis-2020-217425, Clinical characteristics of 17 patients with COVID-19 and systemic autoimmune diseases: a retrospective study, https://ard.bmj.com/content/79/9/1163.
128.
Huang (B) et al., National Science Review, nwaa113, doi:10.1093/nsr/nwaa113, Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19, https://academic.oup.com/nsr/advan..le/doi/10.1093/nsr/nwaa113/5848167.
129.
Huang (C) et al., National Science Review, nwaa113, doi:10.1093/nsr/nwaa113, Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19, https://academic.oup.com/nsr/advan..le/doi/10.1093/nsr/nwaa113/5848167.
131.
Huh et al., International Journal of Infectious Diseases, doi:10.1016/j.ijid.2020.12.041, Association of prescribed medications with the risk of COVID-19 infection and severity among adults in South Korea, https://www.sciencedirect.com/science/article/pii/S1201971220325650.
132.
Huh (B) et al., medRxiv, doi:10.1101/2020.05.04.20089904, Association of previous medications with the risk of COVID-19: a nationwide claims-based study from South Korea, https://www.medrxiv.org/content/10.1101/2020.05.04.20089904v2.
133.
IHU Marseille, Meta-analysis on chloroquine derivatives and COVID-19 mortality, https://www.mediterranee-infection..9-mortality-october20-2020-update/.
134.
Ip et al., BMC Infectious Diseases, doi:10.1186/s12879-021-05773-w (preprint 8/25), Hydroxychloroquine in the treatment of outpatients with mildly symptomatic COVID-19: A multi-center observational study, https://bmcinfectdis.biomedcentral..rticles/10.1186/s12879-021-05773-w.
135.
Ip (B) et al., PLOS ONE, doi:10.1371/journal.pone.0237693, Hydroxychloroquine and Tocilizumab Therapy in COVID-19 Patients - An Observational Study, https://journals.plos.org/plosone/..le?id=10.1371/journal.pone.0237693.
136.
Izoulet M., SSRN, doi:10.2139/ssrn.3575899, Countries which Primarily Use Antimalarial Drugs As COVID-19 Treatment See Slower Dynamic of Daily Deaths, https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3575899.
137.
Jung et al., Clinical Microbiology and Infection, doi:10.1016/j.cmi.2020.12.003, Effect of hydroxychloroquine pre-exposure on infection with SARS-CoV-2 in rheumatic disease patients: A population-based cohort study, https://www.sciencedirect.com/science/article/pii/S1198743X20307527.
139.
Kamran et al., medRxiv, doi:10.1101/2020.07.30.20165365, Clearing the fog: Is HCQ effective in reducing COVID-19 progression: A randomized controlled trial, https://www.medrxiv.org/content/10.1101/2020.07.30.20165365v1.
140.
Kelly et al., British Journal of Clinical Pharmacology, doi:10.1111/bcp.14482, Clinical outcomes and adverse events in patients hospitalised with COVID‐19, treated with off‐label hydroxychloroquine and azithromycin, https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bcp.14482.
141.
Khurana et al., medRxiv, doi:10.1101/2020.07.21.20159301, Prevalence and clinical correlates of COVID-19 outbreak among healthcare workers in a tertiary level hospital, https://www.medrxiv.org/content/10.1101/2020.07.21.20159301v1.
142.
Kim et al., medRxiv, doi:10.1101/2020.05.13.20094193, Treatment Response to Hydroxychloroquine, Lopinavir/Ritonavir, and Antibiotics for Moderate COVID 19: A First Report on the Pharmacological Outcomes from South Korea, https://www.medrxiv.org/content/10..20.05.13.20094193v1?versioned=true.
143.
Kirenga et al., BMJ Open Respiratory Research, doi:10.1136/bmjresp-2020-000646, Characteristics and outcomes of admitted patients infected with SARS-CoV-2 in Uganda, https://bmjopenrespres.bmj.com/content/7/1/e000646.
144.
Komissarov et al., medRxiv, doi:10.1101/2020.06.30.20143289, Hydroxychloroquine has no effect on SARS-CoV-2 load in nasopharynx of patients with mild form of COVID-19, https://www.medrxiv.org/content/10.1101/2020.06.30.20143289v1.
145.
Konig et al., Annals of the Rheumatic Diseases, doi:10.1136/annrheumdis-2020-217690, Baseline use of hydroxychloroquine in systemic lupus erythematosus does not preclude SARS-CoV-2 infection and severe COVID-19, https://ard.bmj.com/content/early/2020/05/20/annrheumdis-2020-217690.
147.
Ladapo et al., medRxiv, doi:10.1101/2020.09.30.20204693, Randomized Controlled Trials of Early Ambulatory Hydroxychloroquine in the Prevention of COVID-19 Infection, Hospitalization, and Death: Meta-Analysis, https://www.medrxiv.org/content/10.1101/2020.09.30.20204693v1.
148.
Lagier et al., Travel Med. Infect. Dis. 101791, Jun 25, 2020, doi:10.1016/j.tmaid.2020.101791, Outcomes of 3,737 COVID-19 patients treated with hydroxychloroquine/azithromycin and other regimens in Marseille, France: A retrospective analysis, https://www.sciencedirect.com/science/article/pii/S1477893920302817.
149.
Lambermont et al., Critical Care Explorations, doi:10.1097/CCE.0000000000000305, Predictors of Mortality and Effect of Drug Therapies in Mechanically Ventilated Patients With Coronavirus Disease 2019: A Multicenter Cohort Study, https://journals.lww.com/ccejourna..rtality_and_Effect_of_Drug.10.aspx.
151.
Lano et al., Clinical Kidney Journal, 13:5, October 2020, 878–888, doi:10.1093/ckj/sfaa199, Risk factors for severity of COVID-19 in chronic dialysis patients from a multicentre French cohort, https://academic.oup.com/ckj/article/13/5/878/5934808.
152.
Laplana et al., PLOS ONE, doi:10.1371/journal.pone.0243598, Lack of protective effect of chloroquine derivatives on COVID-19 disease in a Spanish sample of chronically treated patients, https://journals.plos.org/plosone/..le?id=10.1371/journal.pone.0243598.
153.
Lauriola et al., Clinical and Translational Science, doi:10.1111/cts.12860, Effect of combination therapy of hydroxychloroquine and azithromycin on mortality in COVID‐19 patients, https://ascpt.onlinelibrary.wiley.com/doi/abs/10.1111/cts.12860.
154.
Le Nouvel Afrik, Covid-19 : pourquoi les Marocains décèdent plus en Europe qu’au Maroc, https://www.afrik.com/covid-19-pou..ecedent-plus-en-europe-qu-au-maroc.
155.
Lecronier et al., Critical Care, 24:418, 2020, doi:10.1186/s13054-020-03117-9, Comparison of hydroxychloroquine, lopinavir/ritonavir, and standard of care in critically ill patients with SARS-CoV-2 pneumonia: an opportunistic retrospective analysis, https://ccforum.biomedcentral.com/articles/10.1186/s13054-020-03117-9.
156.
Lee et al., Arch Intern Med., 2011, 171:1, 18-22, doi:10.1001/archinternmed.2010.482, Analysis of Overall Level of Evidence Behind Infectious Diseases Society of America Practice Guidelines, https://jamanetwork.com/journals/j..nternalmedicine/fullarticle/226373.
157.
Li et al., Science China Life Sciences, doi:10.1007/s11427-020-1871-4, Evaluation of the efficacy and safety of hydroxychloroquine in comparison with chloroquine in moderate and severe patients with COVID-19, https://link.springer.com/article/10.1007/s11427-020-1871-4.
158.
Li (B) et al., Research Square, doi:10.21203/rs.3.rs-119202/v1, Treatment of COVID-19 patients with hydroxychloroquine or chloroquine: A retrospective analysis, https://www.researchsquare.com/article/rs-119202/v1.
159.
LifeSiteNews, Doctors insist this cheap, safe drug is “key to preventing huge loss of life” from Wuhan virus, https://www.lifesitenews.com/news/..huge-loss-of-life-from-covid-virus.
162.
Ly et al., International Journal of Antimicrobial Agents, doi:10.1016/j.ijantimicag.2020.106219 (preprint 8/21), Pattern of SARS-CoV-2 infection among dependant elderly residents living in retirement homes in Marseille, France, March-June 2020, https://www.sciencedirect.com/scie../article/abs/pii/S0924857920304301.
163.
Lyngbakken et al., Nature Communications, doi:10.1038/s41467-020-19056-6, A pragmatic randomized controlled trial reports lack of efficacy of hydroxychloroquine on coronavirus disease 2019 viral kinetics, https://www.nature.com/articles/s41467-020-19056-6.
164.
Macias et al., medRxiv, 10.1101/2020.05.16.20104141, Similar incidence of Coronavirus Disease 2019 (COVID-19) in patients with rheumatic diseases with and without hydroxychloroquine therapy, https://www.medrxiv.org/content/10.1101/2020.05.16.20104141v1.
166.
Mahévas et al., BMJ 2020, 369, doi: https://doi.org/10.1136/bmj.m1844, Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen: observational comparative study using routine care data, https://www.bmj.com/content/369/bmj.m1844.
167.
Maldonado et al., Nefrología, doi:10.1016/j.nefro.2020.09.002, COVID-19 incidence and outcomes in a home dialysis unit in Madrid (Spain) at the height of the pandemic, https://www.sciencedirect.com/science/article/pii/S0211699520301661.
168.
Mallat et al., Medicine (Baltimore), doi:10.1097/MD.0000000000023720 (preprint 5/2), Hydroxychloroquine is associated with slower viral clearance in clinical COVID-19 patients with mild to moderate disease: A retrospective study, https://journals.lww.com/md-journa..sociated_with_slower_viral.34.aspx.
169.
Martinez-Lopez et al., Blood Cancer Journal, doi:10.1038/s41408-020-00372-5, Multiple Myeloma and SARS-CoV-2 Infection: Clinical Characteristics and Prognostic Factors of Inpatient Mortality, https://www.nature.com/articles/s41408-020-00372-5.
170.
Matangila et al., PLOS ONE, doi:10.1371/journal.pone.0244272, Clinical characteristics of COVID-19 patients hospitalized at Clinique Ngaliema, a public hospital in Kinshasa, in the Democratic Republic of Congo: A retrospective cohort study, https://journals.plos.org/plosone/..le?id=10.1371/journal.pone.0244272.
171.
Mathai et al., J. Marine Medical Society, doi:10.4103/jmms.jmms_115_20, Hydroxychloroquine as pre-exposure prophylaxis against COVID-19 in health-care workers: A single-center experience, https://www.marinemedicalsociety.in/preprintarticle.asp?id=300159.
172.
McGrail et al., medRxiv, doi:10.1101/2020.07.17.20156521, COVID-19 Case Series at UnityPoint Health St. Luke’s Hospital in Cedar Rapids, IA, https://www.medrxiv.org/content/10.1101/2020.07.17.20156521v1.
173.
McLean et al., Open Forum Infect. Dis. September 2015, 2:3, doi:10.1093/ofid/ofv100, Impact of Late Oseltamivir Treatment on Influenza Symptoms in the Outpatient Setting: Results of a Randomized Trial, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525010/.
175.
Medical Xpress, Senegal says hydroxychloroquine virus treatment is promising, https://medicalxpress.com/news/202..xychloroquine-virus-treatment.html.
176.
Medical Xpress (B), Amid global controversy, Greece moves forward with chloroquine, https://medicalxpress.com/news/202..ontroversy-greece-chloroquine.html.
177.
Membrillo de Novales et al., Preprints 2020, 2020050057, doi:10.20944/preprints202005.0057.v1, Early Hydroxychloroquine Is Associated with an Increase of Survival in COVID-19 Patients: An Observational Study, https://www.preprints.org/manuscript/202005.0057.
178.
Meneguesso, A., Médica defende tratamento precoce da Covid-19, https://www.youtube.com/watch?v=X5FCrIm_19U.
179.
Middle East Eye, Coronavirus: Turkey says hydroxychloroquine dramatically reduces pneumonia cases, https://www.middleeasteye.net/news..roquine-malaria-treatment-progress.
181.
Ministerstva Zdravotnictví, Rozhodnutí o dočasném povolení neregistrovaného humánního léčivého přípravku HYDROXYCHLOROQUINE SULFATE TABLETS, https://www.mzcr.cz/rozhodnuti-o-d..ydroxychloroquine-sulfate-tablets/.
182.
Ministry of Health of Ukraine, ПРОТОКОЛ «НАДАННЯ МЕДИЧНОЇ ДОПОМОГИ ДЛЯ ЛІКУВАННЯ КОРОНАВІРУСНОЇ ХВОРОБИ (COVID-19)» , https://www.dec.gov.ua/wp-content/..04/2020_762_protokol_covid19-f.pdf.
183.
Ministry of Health of Ukraine (B), «НАДАННЯ МЕДИЧНОЇ ДОПОМОГИ ДЛЯ ЛІКУВАННЯ КОРОНАВІРУСНОЇ ХВОРОБИ (COVID-19), https://moz.gov.ua/uploads/5/26129-dn_2106_17_09_2020_dod_1.pdf.
184.
Mitchell et al., SSRN, doi:10.2139/ssrn.3586954, Markedly Lower Rates of Coronavirus Infection and Fatality in Malaria-Endemic Regions – A Clue As to Treatment?, https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3586954.
185.
Mitjà et al., Clinical Infectious Diseases, ciaa1009, doi:10.1093/cid/ciaa1009, Hydroxychloroquine for Early Treatment of Adults with Mild Covid-19: A Randomized-Controlled Trial, https://academic.oup.com/cid/article/doi/10.1093/cid/ciaa1009/5872589.
186.
Mitjà (B) et al., NEJM, doi:10.1056/NEJMoa2021801 (preprint 7/26), A Cluster-Randomized Trial of Hydroxychloroquine as Prevention of Covid-19 Transmission and Disease, https://www.nejm.org/doi/full/10.1056/NEJMoa2021801.
187.
Modrák et al., medRxiv, doi:10.1101/2020.12.03.20239863, Detailed disease progression of 213 patients hospitalized with Covid-19 in the Czech Republic: An exploratory analysis, https://www.medrxiv.org/content/10.1101/2020.12.03.20239863v1.
188.
Morocco World News, Moroccan Scientist: Morocco’s Chloroquine Success Reveals European Failures, https://www.moroccoworldnews.com/2..success-reveals-european-failures/.
189.
Mosaique Guinee, Traitement des malades de covid19 en Guinée: « nous continuons avec l’hydroxychloroquine » (ANSS), https://mosaiqueguinee.com/traitem..ons-avec-lhydroxychloroquine-anss/.
190.
Nachega et al., The American Journal of Tropical Medicine and Hygiene, doi:10.4269/ajtmh.20-1240, Clinical Characteristics and Outcomes of Patients Hospitalized for COVID-19 in Africa: Early Insights from the Democratic Republic of the Congo, https://www.ajtmh.org/content/journals/10.4269/ajtmh.20-1240.
191.
Ñamendys-Silva et al., Heart & Lung, doi:10.1016/j.hrtlng.2020.10.013, Outcomes of patients with COVID-19 in the Intensive Care Unit in Mexico: A multicenter observational study, https://www.sciencedirect.com/science/article/pii/S014795632030412X.
192.
Naseem et al., medRxiv, doi:10.1101/2020.12.13.20247254, Predicting mortality in SARS-COV-2 (COVID-19) positive patients in the inpatient setting using a Novel Deep Neural Network, https://www.medrxiv.org/content/10.1101/2020.12.13.20247254v1.
194.
Nigeria News World, COVID-19: Jigawa govt reveals secret behind mass recovery of patients, https://nigerianewsworld.com/news/..-behind-mass-recovery-of-patients/.
195.
NPR News, Senegal pledges a bed for every coronavirus patient, https://wfuv.org/content/senegal-p..t-%E2%80%94-and-their-contacts-too.
196.
Núñez-Gil et al., Intern. Emerg. Med., doi:10.1007/s11739-020-02543-5, Mortality risk assessment in Spain and Italy, insights of the HOPE COVID-19 registry, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649104/.
197.
Omrani et al., EClinicalMedicine, doi:10.1016/j.eclinm.2020.100645, Randomized double-blinded placebo-controlled trial of hydroxychloroquine with or without azithromycin for virologic cure of non-severe Covid-19, https://www.sciencedirect.com/science/article/pii/S2589537020303898.
198.
Oneindia, No COVID-19 death in Manipur, Mizoram, Nagaland, Sikkim so far: Govt, https://www.oneindia.com/india/no-..o-far-health-ministry-3111048.html.
199.
Orioli et al., Diabetes & Metabolic Syndrome: Clinical Research & Reviews, doi:10.1016/j.dsx.2020.12.020, Clinical characteristics and short-term prognosis of in-patients with diabetes and COVID-19: A retrospective study from an academic center in Belgium, https://www.sciencedirect.com/science/article/pii/S1871402120305154.
200.
Ozturk et al., Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfaa271, Mortality analysis of COVID-19 infection in chronic kidney disease, haemodialysis and renal transplant patients compared with patients without kidney disease: a nationwide analysis from Turkey, https://academic.oup.com/ndt/article/35/12/2083/6020341.
201.
Paccoud et al., Clinical Infectious Diseases, doi:10.1093/cid/ciaa791, Compassionate use of hydroxychloroquine in clinical practice for patients with mild to severe Covid-19 in a French university hospital, https://academic.oup.com/cid/article/doi/10.1093/cid/ciaa791/5859555.
202.
Pan African Medical Journal, Clinical characteristics, treatment regimen and duration of hospitalization among COVID-19 patients in Ghana: a retrospective cohort study, https://www.panafrican-med-journal.com/content/series/37/1/9/full/.
204.
Peng et al., Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfaa288, Early versus late acute kidney injury among patients with COVID-19—a multicenter study from Wuhan, China , https://academic.oup.com/ndt/article/35/12/2095/6020340.
205.
Peters et al., Clinical Microbiology and Infection, doi:10.1016/j.cmi.2020.10.004 (preprint 8/15), Outcomes of Persons With COVID-19 in Hospitals With and Without Standard Treatment With (Hydroxy)chloroquine, https://www.clinicalmicrobiologyan..cle/S1198-743X(20)30615-7/fulltext.
206.
Pilot News, Chloroquine Can Treat Coronavirus at Early Stage – NAFDAC DG, https://www.westafricanpilotnews.c..onavirus-at-early-stage-nafdac-dg/.
208.
PledgeTimes, Russian Ministry of Health has updated recommendations for the treatment of COVID-19, https://pledgetimes.com/russian-mi..ons-for-the-treatment-of-covid-19/.
209.
Pleno.News, Cuba stands out in combating Covid with hydroxychloroquine, https://pleno.news/saude/coronavir..a-covid-com-hidroxicloroquina.html.
211.
Prodromos et al., New Microbes and New Infections, doi:10.1016/j.nmni.2020.100776, Hydroxychloroquine is effective, and consistently so used early, for Covid-19: A systematic review, https://www.sciencedirect.com/science/article/pii/S2052297520301281.
212.
Psevdos et al., Open Forum Infectious Diseases, doi:10.1093/ofid/ofaa439.721, Corona Virus Disease-19 (COVID-19) in a Veterans Affairs Hospital at Suffolk County, Long Island, New York, https://academic.oup.com/ofid/article/7/Supplement_1/S330/6057008.
213.
Q Costa Rica, Hydroxychloroquine: The Drug Costa Rica Uses Successfully To Fight Covid-19, https://qcostarica.com/hydroxychlo..es-successfully-to-fight-covid-19/.
214.
Qin et al., Thrombosis Research, doi:10.1016/j.thromres.2020.11.020, Low molecular weight heparin and 28-day mortality among patients with coronavirus disease 2019: A cohort study in the early epidemic era, https://www.sciencedirect.com/science/article/pii/S0049384820306277.
215.
Rajasingham et al., medRxiv, doi:10.1101/2020.09.18.20197327, Hydroxychloroquine as pre-exposure prophylaxis for COVID-19 in healthcare workers: a randomized trial, https://academic.oup.com/cid/advan..e/doi/10.1093/cid/ciaa1571/5929230.
218.
RECOVERY Collaborative Group, NEJM, doi:10.1056/NEJMoa2022926 (press release 6/5), Effect of Hydroxychloroquine in Hospitalized Patients with COVID-19: Preliminary results from a multi-centre, randomized, controlled trial, https://www.nejm.org/doi/full/10.1056/NEJMoa2022926.
219.
Rentsch et al., The Lancet Rheumatology, doi:10.1016/S2665-9913(20)30378-7 (preprint 9/9, https://www.medrxiv.org/content/10.1101/2020.09.04.20187781v1), Effect of pre-exposure use of hydroxychloroquine on COVID-19 mortality: a population-based cohort study in patients with rheumatoid arthritis or systemic lupus erythematosus using the OpenSAFELY platform, https://www.sciencedirect.com/science/article/pii/S2665991320303787.
221.
Rivera et al., Cancer Discovery, doi:10.1158/2159-8290.CD-20-0941, Utilization of COVID-19 Treatments and Clinical Outcomes among Patients with Cancer: A COVID-19 and Cancer Consortium (CCC19) Cohort Study, https://cancerdiscovery.aacrjourna..ly/2020/09/12/2159-8290.CD-20-0941.
222.
Rivera-Izquierdo et al., Medicina Clínica, doi:10.1016/j.medcli.2020.06.025, Agentes terapéuticos utilizados en 238 pacientes hospitalizados por COVID-19 y su relación con la mortalidad, https://www.sciencedirect.com/science/article/pii/S0025775320304486.
224.
Rodriguez-Nava et al., Mayo Clinic Proceedings: Innovations, Quality & Outcomes, Clinical characteristics and risk factors for mortality of hospitalized patients with COVID-19 in a community hospital: A retrospective cohort study, https://www.sciencedirect.com/science/article/pii/S2542454820302071.
225.
Roomi et al., J. Medical Internet Research, doi:10.2196/21758, Efficacy of hydroxychloroquine and tocilizumab in patients with COVID-19: A single-center retrospective chart review, https://www.jmir.org/2020/9/e21758/.
226.
Rosenberg et al., JAMA, May 11, 2020, doi:10.1001/jama.2020.8630, Association of Treatment With Hydroxychloroquine or Azithromycin With In-Hospital Mortality in Patients With COVID-19 in New York State, https://jamanetwork.com/journals/jama/fullarticle/2766117.
227.
Russian Government, ВРЕМЕННЫЕ МЕТОДИЧЕСКИЕ РЕКОМЕНДАЦИИ ПРОФИЛАКТИКА, ДИАГНОСТИКА И ЛЕЧЕНИЕ НОВОЙ КОРОНАВИРУСНОЙ ИНФЕКЦИИ (COVID-19), https://static-0.minzdrav.gov.ru/s..D0%9C%D0%A0_COVID-19_%28v.9%29.pdf.
228.
Russian Government (B), Распоряжение Правительства Российской Федерации от 16.04.2020 № 1030-р, http://publication.pravo.gov.ru/Document/View/0001202004160037#print.
229.
Salazar et al., The American Journal of Pathology, doi:10.1016/j.ajpath.2020.10.008, Significantly Decreased Mortality in a Large Cohort of Coronavirus Disease 2019 (COVID-19) Patients Transfused Early with Convalescent Plasma Containing High-Titer Anti–Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein IgG, https://www.sciencedirect.com/science/article/pii/S0002944020304892.
230.
Saleemi et al., medRxiv, doi:10.1101/2020.08.05.20151027, Time to negative PCR from symptom onset in COVID-19 patients on Hydroxychloroquine and Azithromycin - A real world experience, https://www.medrxiv.org/content/10.1101/2020.08.05.20151027v1.
231.
Sánchez-Álvarez et al., Nefrología, doi:10.1016/j.nefroe.2020.04.002, Status of SARS-CoV-2 infection in patients on renal replacement therapy. Report of the COVID-19 Registry of the Spanish Society of Nephrology (SEN), https://www.sciencedirect.com/science/article/pii/S201325142030050X.
232.
Sands et al., International Journal of Infectious Diseases, doi:/10.1016/j.ijid.2020.12.060, No clinical benefit in mortality associated with hydroxychloroquine treatment in patients with COVID-19, https://www.sciencedirect.com/science/article/pii/S1201971220325832.
233.
Sarfaraz et al., medRxiv, doi:10.1101/2020.12.28.20248920, Determinants of in-hospital mortality in COVID-19; a prospective cohort study from Pakistan, https://www.medrxiv.org/content/10.1101/2020.12.28.20248920v1.
234.
Sbidian et al., medRxiv, doi:10.1101/2020.06.16.20132597, Hydroxychloroquine with or without azithromycin and in-hospital mortality or discharge in patients hospitalized for COVID-19 infection: a cohort study of 4,642 in-patients in France, https://www.medrxiv.org/content/10.1101/2020.06.16.20132597v1.
235.
Self et al., JAMA, doi:10.1001/jama.2020.22240, Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19: A Randomized Clinical Trial, https://jamanetwork.com/journals/jama/fullarticle/2772922.
237.
Shabrawishi et al., medRxix, doi:10.1101/2020.05.08.20095679, Negative nasopharyngeal SARS-CoV-2 PCR conversion in response to different therapeutic interventions, https://www.medrxiv.org/content/10.1101/2020.05.08.20095679v1.
238.
Sheshah et al., Diabetes Research and Clinical Practice, doi:10.1016/j.diabres.2020.108538, Prevalence of Diabetes, Management and Outcomes among Covid-19 Adult Patients Admitted in a Specialized Tertiary Hospital in Riyadh, Saudi Arabia, https://www.sciencedirect.com/science/article/pii/S0168822720307956.
244.
Singh et al., medRxiv, doi:10.1101/2020.05.12.20099028, Outcomes of Hydroxychloroquine Treatment Among Hospitalized COVID-19 Patients in the United States- Real-World Evidence From a Federated Electronic Medical Record Network, https://www.medrxiv.org/content/10.1101/2020.05.12.20099028v1.
245.
Skipper et al., Annals of Internal Medicine, doi:10.7326/M20-4207, Hydroxychloroquine in Nonhospitalized Adults With Early COVID-19: A Randomized Trial, https://www.acpjournals.org/doi/10.7326/M20-4207.
246.
Solh et al., medRxiv, doi:10.1101/2020.10.16.20214130, Clinical course and outcome of COVID-19 acute respiratory distress syndrome: data from a national repository, https://www.medrxiv.org/content/10.1101/2020.10.16.20214130v1.
248.
Sosa-García et al., Cir Cir. 2020, 88:5, 569-575, doi:10.24875/CIRU.20000675, Experience in the management of severe COVID-19 patients in an intensive care unit, https://cirugiaycirujanos.com/frame_esp.php?id=358.
249.
Soto-Becerra et al., medRxiv, doi:10.1101/2020.10.06.20208066, Real-World Effectiveness of hydroxychloroquine, azithromycin, and ivermectin among hospitalized COVID-19 patients: Results of a target trial emulation using observational data from a nationwide Healthcare System in Peru, https://www.medrxiv.org/content/10.1101/2020.10.06.20208066v1.
250.
Su et al., BioScience Trends, doi:10.5582/bst.2020.03340, Efficacy of early hydroxychloroquine treatment in preventing COVID-19 pneumonia aggravation, the experience from Shanghai, China, https://www.jstage.jst.go.jp/artic..vpub_2020.03340/_article/-char/ja/.
251.
Sulaiman et al., medRxiv, doi:10.1101/2020.09.09.20184143, The Effect of Early Hydroxychloroquine-based Therapy in COVID-19 Patients in Ambulatory Care Settings: A Nationwide Prospective Cohort Study, https://www.medrxiv.org/content/10.1101/2020.09.09.20184143v1.
252.
Sweeting et al., Statistics in Medicine, doi:10.1002/sim.1761, What to add to nothing? Use and avoidance of continuity corrections in meta‐analysis of sparse data, https://onlinelibrary.wiley.com/doi/10.1002/sim.1761.
253.
Synolaki et al., medRxiv, doi:10.1101/2020.09.05.20184655, The Activin/Follistatin-axis is severely deregulated in COVID-19 and independently associated with in-hospital mortality, https://www.medrxiv.org/content/10.1101/2020.09.05.20184655v2.
254.
Taccone et al., The Lancet Regional Health - Europe, doi:10.1016/j.lanepe.2020.100019, The role of organizational characteristics on the outcome of COVID-19 patients admitted to the ICU in Belgium, https://www.sciencedirect.com/science/article/pii/S2666776220300193.
256.
Tang et al., BMJ 2020, 369, doi:10.1136/bmj.m1849, Hydroxychloroquine in patients with COVID-19: an open-label, randomized, controlled trial, https://www.bmj.com/content/369/bmj.m1849.
257.
Tehrani et al., International Journal of Infectious Diseases, doi:10.1016/j.ijid.2020.10.071, Risk factors for mortality in adult COVID-19 patients; frailty predicts fatal outcome in older patients, https://www.sciencedirect.com/science/article/pii/S1201971220322761.
258.
Teller Report, Coronavirus: a study in Senegal confirms the effectiveness of hydroxychloroquine, http://www.tellerreport.com/news/2..hydroxychloroquine.BJeet4Kst8.html.
259.
Texeira et al., Open Forum Infectious Diseases, doi:10.1093/ofid/ofaa439.560, Characteristics and outcomes of COVID-19 patients admitted to a regional health system in the southeast, https://academic.oup.com/ofid/article/7/Supplement_1/S251/6058327.
260.
The Africa Report, Coronavirus: Didier Raoult the African and chloroquine, from Dakar to Brazzaville, https://www.theafricareport.com/26..roquine-from-dakar-to-brazzaville/.
262.
The BL, Russia supports the use of hydroxychloroquine, the drug to treat the CCP Virus suggested by Trump, https://thebl.com/world-news/russi..oroquine-drug-ccp-virus-trump.html.
263.
The East African, Algeria backs use of malaria drug despite WHO dropping trials, https://www.theeastafrican.co.ke/n../4552902-5564930-duphp6/index.html.
264.
The Guardian, Chloroquine potent for COVID-19 prevention, says NAFDAC, https://guardian.ng/news/nigeria/n..r-covid-19-prevention-says-nafdac/.
265.
The Indian Express, Vadodara administration drive: HCQ helping in containing Covid-19 cases, say docs as analysis begins, https://indianexpress.com/article/..y-docs-as-analysis-begins-6486049/.
266.
The Moscow Times, Russia Approves Unproven Malaria Drug to Treat Coronavirus, https://www.themoscowtimes.com/202..a-drug-to-treat-coronavirus-a70025.
267.
The New York Times, Malaria Drug Taken by Trump Is Tied to Increased Risk of Heart Problems and Death in New Study, https://www.nytimes.com/2020/05/22..alaria-drug-trump-coronavirus.html.
268.
The New York Times (B), Small Chloroquine Study Halted Over Risk of Fatal Heart Complications, https://www.nytimes.com/2020/04/12..ronavirus-trump.html?smid=em-share.
269.
The New York Times (C), Malaria Drug Promoted by Trump Did Not Prevent Covid Infections, Study Finds, https://www.nytimes.com/2020/06/03..chloroquine-coronavirus-trump.html.
270.
The New York Times (D), Coronavirus Can Be Deadly for Young Adults, Too, Study Finds, https://www.nytimes.com/2020/09/10/world/covid-19-coronavirus.html.
272.
The Tico Times, News briefs: Reopening plans on-track, hydroxychloroquine use to continue, partnership with Coursera, https://ticotimes.net/2020/06/15/n..continue-partnership-with-coursera.
273.
Treanor et al., JAMA, 2000, 283:8, 1016-1024, doi:10.1001/jama.283.8.1016, Efficacy and Safety of the Oral Neuraminidase Inhibitor Oseltamivir in Treating Acute Influenza: A Randomized Controlled Trial, https://jamanetwork.com/journals/jama/fullarticle/192425.
274.
Trefond et al., SSRM, doi:10.2139/ssrn.3754815, Impact of hydroxychloroquine used as DMARD on SARS CoV-2 tests and COVID-19 evolution, https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3754815.
275.
Trullàs et al., Research Square, doi:10.21203/rs.3.rs-39421/v1 , High in-hospital mortality due to COVID-19 in a community hospital in Spain: a prospective observational study, https://www.researchsquare.com/article/rs-39421/v1.
276.
Ukrinform, Ukraine receives batch of hydroxychloroquine tablets from India, https://www.ukrinform.net/rubric-e..ose-down-in-ukraine-on-june-3.html.
277.
Ulrich et al., Open Forum Infectious Diseases, doi:10.1093/ofid/ofaa446, Treating Covid-19 With Hydroxychloroquine (TEACH): A Multicenter, Double-Blind, Randomized Controlled Trial in Hospitalized Patients, https://academic.oup.com/ofid/adva..e/doi/10.1093/ofid/ofaa446/5910201.
279.
van Halem et al., BMC Infect Dis., doi:10.1186/s12879-020-05605-3, Risk factors for mortality in hospitalized patients with COVID-19 at the start of the pandemic in Belgium: a retrospective cohort study, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691970/.
280.
Vanguard, COVID-19: Nigerian study finds Chloroquine, Hydroxychloroquine effective as Prophylaxis, https://www.vanguardngr.com/2020/0..oroquine-effective-as-prophylaxis/.
281.
Vernaz et al., Swiss Medical Weekly, doi:10.4414/smw.2020.20446 , Early experimental COVID-19 therapies: associations with length of hospital stay, mortality and related costs, https://smw.ch/article/doi/smw.2020.20446.
283.
Wang et al., medRxiv, doi:10.1101/2020.06.11.20128926, Comorbidity and Sociodemographic determinants in COVID-19 Mortality in an US Urban Healthcare System, https://www.medrxiv.org/content/10.1101/2020.06.11.20128926v1.
284.
Xia et al., ChiCTR2000029741, Efficacy of Chloroquine and Lopinavir/ Ritonavir in mild/general novel coronavirus (CoVID-19) infections: a prospective, open-label, multicenter randomized controlled clinical study, http://www.chictr.org.cn/showproj.aspx?proj=49263.
285.
Yegerov et al., medRxiv, doi:10.1101/2021.01.06.20249091, Epidemiological and Clinical Characteristics, and Virologic Features of COVID-19 Patients in Kazakhstan: a Nation-Wide, Retrospective, Cohort Study, https://www.medrxiv.org/content/10.1101/2021.01.06.20249091v1.
286.
Yu et al., Science China Life Sciences, 2020 Aug 3, doi:10.1007/s11427-020-1782-1, Beneficial effects exerted by hydroxychloroquine in treating COVID-19 patients via protecting multiple organs, https://link.springer.com/article/10.1007/s11427-020-1782-1.
287.
Yu (B) et al., Science China Life Sciences, 2020 Aug 3, doi:10.1007/s11427-020-1782-1, Beneficial effects exerted by hydroxychloroquine in treating COVID-19 patients via protecting multiple organs, https://link.springer.com/article/10.1007/s11427-020-1782-1.
289.
Zhang et al., JAMA, 80:19, 1690, doi:10.1001/jama.280.19.1690, What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes, https://jamanetwork.com/journals/jama/fullarticle/188182.
290.
Zhong Nanshan (钟南山), Efficacy and safety of chloroquine for treatment of COVID-19. An open-label, multi-center, non-randomized trial, https://twitter.com/JamesTodaroMD/status/1243260720944480265.
291. Zhong (B) et al., Lancent Rheumatology, 10.1016/S2665-9913(20)30227-7, COVID-19 in patients with rheumatic disease in Hubei province, China: a multicentre retrospective observational study, https://www.thelancet.com/journals../PIIS2665-9913(20)30227-7/fulltext.
SOURCE: https://hcqmeta.com/

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Lumbrokinase, nattokinase, and serrapeptase are all enzymes that have been studied for their potential health benefits. They are all considered as proteolytic enzymes. Proteolytic enzymes have a variety of roles in the body, from helping to digest food to taking part in the immune response. What is Lumbrokinase? Lumbrokinase (LK) is an enzyme derived from earthworms is thought to aid in blood clot prevention, inflammation reduction, and circulation problems.  Lumbrokinase for Blood Clots Thrombolytic agents typically used to dissolve clots are urokinase (u-PA), streptokinase, and tissue plasminogen activator (t-PA). These drugs, however, are not specific for fibrin and have adverse and dangerous side effects including severe bleeding and heavy blood loss which may result in death. In contrast, LK is very specific to fibrin as a substrate and it does not cause excessive bleeding. It can dissolve the fibrin itself or convert plasminogen to plasmin by inducing endogenous t-PA activity to
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Fenbendazole vs Mebendazole: What is the Difference?

By Dr. Frank Yap, MD -
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Fenbendazole for Humans Fenbendazole (also known as fenben) is a veterinary medication used to treat parasites and worms such as tapeworms, hookworms, roundworms, and whipworms, in animals. It is commonly used under brand names like Panacur C and Safe-Guard. Recently, researchers have been experimenting with fenbendazole for humans cancer. Though the studies are limited, what researchers have found so far is promising for cancer patients. Many cancer patients have been following the Fenbendazole for cancer Protocol . However, fenbendazole isn’t the only worming medication that has the potential to fight cancer. Researchers have also been studying how Mebendazole, a drug that can treat worms in humans, could be just as, or even more, effective at shrinking tumors and killing cancer cells. Here’s what you need to know about each of these medications: Fenbendazole vs. Mebendazole Fenbendazole is part of a larger group of drugs known as benzimidazole, which are anthelmintic dr
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NAC vs NAD vs NR vs NMN? What are the Differences?

By Dr. Frank Yap, MD -
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NAC vs NAD vs NR vs NMN ? Due to the small alphabetical differences, these supplements are often mixed up and confused by most consumers. We will cover the essentials and explain about each of these supplements below. NAD NAD is derived from Nicotinamide Riboside (NR). The levels of NAD in our body determine the speed of aging process. In younger cells and tissues, the levels of NAD are higher. As a result, younger people tend to have better physical activity, cognitive function and potential for cell repair and regeneration. As we grow, the levels of NAD in our body start to decline. This is reflected in the form of slowed cognitive response, loss of memory and reduced agility. Research suggests it may be possible to reverse mitochondrial decay with dietary supplements that increase cellular levels of a molecule called NAD (nicotinamide adenine dinucleotide).  NAD is a linchpin of energy metabolism, among other roles, and its diminishing level with age has been implicated in mitochond
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How Linoleic Acid Wrecks Your Health (2024) - Dr Mercola

By Dr. Frank Yap, MD -
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The majority of Americans might be misled by official health recommendations to eat “healthy” vegetable oils. Even the term “vegetable oil” is misleading because it gives you the impression that you are receiving vegetable micronutrients when these oils are actually highly toxic, industrially-processed seed oils. Seed oils are some of the most dangerous items you could eat. Tucker Goodrich and Dr Mercola discussed what will be the topic of Dr Mercola's next book, namely linoleic acid (LA), which he believed is likely the leading contributing cause of virtually all chronic diseases we've encountered over the last century. Unfortunately, this is a topic that most clinicians and health care practitioners who focus on natural medicine have only a superficial understanding of.   Goodrich has a business background as a stockbroker and asset manager, and developed an IT risk management system used by two of the largest hedge funds in the w
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FLCCC I-MASK+ Protocol for COVID-19

By Dr. Frank Yap, MD -
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FLCCC (Front Line COVID-19 Critical Care) I-MASK+ Protocol I-MASK+ Prevention & Early Outpatient Treatment Protocol for COVID-19 was designed for use as a prevention and in early outpatient treatment, for those who test positive for COVID-19. Component nutrients include vitamin D, C, melatonin, quercetin and zinc . All the component medicines are FDA-approved (except ivermectin), inexpensive, readily available and have been used for decades with well-established safety profiles. Please take note that I-MASK+ protocols are now: I-PREVENT protocol for prevention (prophylaxis) I-CARE protocol for early treatment . PREVENTION PROTOCOL As rates of infection with influenza and RSV rose in fall/winter 2022, FLCCC adapted th
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The Key to Reversing All Autoimmune Diseases - Dr Mercola

By Dr. Frank Yap, MD -
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It has been estimated that over 54.4 million people in the United States have an autoimmune disease  ( R ).   Some of the major ones would be rheumatoid arthritis (RA), multiple sclerosis and inflammatory bowel diseases like Crohn's and ulcerative colitis. Since I have a massive clinical experience with RA (Rheumatoid Arthritis), I am going to use it as an example of how all autoimmune diseases can be treated. Why? Because they all have similar origins which are related to an antigen sneaking into your body and your immune system confusing it as a foreign invader. The antigen that gets into your system determines which of your body's tissues will be impacted. From the late 1980s and for the following 10 years, I treated over 3,000 patients with rheumatic illnesses, including systemic lupus erythematosus (SLE), scleroderma, polymyositis and dermatomyositis. RA has a devastating prognosis in many patients. Rheumatoid arthritis affects about 1% of our population
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Fenbendazole Joe Tippens Protocol: A Simple Step-by-Step Guide

By Dr. Frank Yap, MD -
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If you have been diagnosed with cancer, or have a loved one that is suffering from cancer, chances are you have heard about the Joe Tippens Cancer Protocol. The Fenbendazole Cancer Protocol has been gaining rapid interest over the past years following some fenbendazole advanced cancer success stories. Joe Tippens  founded the protocol  after he was told a story about a scientist at Merck Animal Health that had been performing cancer research on mice. The research included injecting different types of cancers into different mice body parts. The scientists discovered, through trial and error, a product in their canine product line, fenbendazole, that was batting 1.000 in killing these different cancers in the mice. The scientist was later diagnosed with stage 4 brain cancer and was given a grim prognosis of only three months to live. She decided to try the fenbendazole, and after six weeks, showed a clean scan. Joe Tippens had been initially diagnosed with small cell lung cancer. The can
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