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Blood iron levels could be key to slowing aging, gene study shows
Genes linked to ageing that could help explain why some people age at different rates to others have been identified by scientists.
The international study (Nature Communications, 2020) using genetic data from more than a million people suggests that maintaining healthy levels of iron in the blood could be a key to ageing better and living longer.
The findings could accelerate the development of drugs to reduce age-related diseases, extend healthy years of life and increase the chances of living to old age free of disease, the researchers say.
Scientists from the University of Edinburgh and the Max Planck Institute for Biology of Ageing in Germany focused on three measures linked to biological ageing -- lifespan, years of life lived free of disease (healthspan), and being extremely long-lived (longevity).
Biological ageing -- the rate at which our bodies decline over time -- varies between people and drives the world's most fatal diseases, including heart disease, dementia and cancers.
The researchers pooled information from three public datasets to enable an analysis in unprecedented detail. The combined dataset was equivalent to studying 1.75 million lifespans or more than 60,000 extremely long-lived people.
The team pinpointed ten regions of the genome linked to long lifespan, healthspan and longevity. They also found that gene sets linked to iron were overrepresented in their analysis of all three measures of ageing.
The researchers confirmed this using a statistical method -- known as Mendelian randomisation -- that suggested that genes involved in metabolising iron in the blood are partly responsible for a healthy long life.
Blood iron is affected by diet and abnormally high or low levels are linked to age-related conditions such as Parkinson's disease, liver disease and a decline in the body's ability to fight infection in older age.
The researchers say that designing a drug that could mimic the influence of genetic variation on iron metabolism could be a future step to overcome some of the effects of ageing, but caution that more work is required.
The study was funded by the Medical Research Council and is published in the journal Nature Communications.
Anonymised datasets linking genetic variation to healthspan, lifespan, and longevity were downloaded from the publically available Zenodo, Edinburgh DataShare and Longevity Genomics servers.
Dr Paul Timmers from the Usher Institute at the University of Edinburgh, said: "We are very excited by these findings as they strongly suggest that high levels of iron in the blood reduces our healthy years of life, and keeping these levels in check could prevent age-related damage. We speculate that our findings on iron metabolism might also start to explain why very high levels of iron-rich red meat in the diet has been linked to age-related conditions such as heart disease."
Dr Joris Deelen from the Max Planck Institute for Biology of Ageing in Germany, said: "Our ultimate aim is to discover how ageing is regulated and find ways to increase health during ageing. The ten regions of the genome we have discovered that are linked to lifespan, healthspan and longevity are all exciting candidates for further studies."
If you're looking for the best orthopaedic doctors in Klang Valley, you've come to the right place. Best Orthopedic Doctors in Klang Valley Choosing the right orthopedic surgeon in Malaysia is not as simple as choosing a GP to get your next MC. An orthopedic surgeon is a medical specialist and they do sub-specialize in various orthopedic related sub-specialties. Examples of orthopedic sub-specialties include: Hand surgery Shoulder and elbow surgery Total joint reconstruction (arthroplasty) Skull reconstruction Pediatric orthopedics Foot and ankle surgery Spine surgery Musculoskeletal oncology Surgical sports medicine Orthopedic trauma Orthopaedic Oncology To assist you in finding the best orthopedic doctor in Malaysia, we have compiled a list of orthopedic surgery clinics below. Selection Methodology: The selection of the clinics is based on Google Search Results, reviews and information available on blogs and forums . Disclaimer: The list of clinics has been arranged in no par
If you are looking for the best urologists in Malaysia , you've come to the right place. Urology is the surgical specialty that focuses on the urinary tracts of males and females, and on the reproductive system of males. Some of the diseases treated by an urologist are: Erectile Dysfunction Fallen Bladder Bladder Control Problems Painful Bladder System Prostate/Bladder Cancer A testicular mass Infertility (Male) Male Circumcision Urinary or Kidney Stones Difficulty Urinating Stress Incontinence Urinary Tract Infection Here is a list of the best urologists you can find in Malaysia. Note: This list is in no particular order. 1. Dr. Kenneth Koh Beng Hock - Gleneagles (Ampang) Kuala Lumpur Address and Contact: Gleneagles Kuala Lumpur Address: 282 and 286, Jalan Ampang, 50450 Kuala Lumpur, Malaysia. Telephone Contact Number: +603-4141 3000 Ambulance Line: +603 4141 3131 Other Urologists in Gleneagles Kuala Lumpur: Dr. Chua Chong Beng - Urologist (Surgeon) Dr. Lam Hock Shang - Urologist
If you are looking for Dr Ranjit Skin Specialist Clinic reviews , you've come to the right place. Image via Source Address for Dr Ranjit's clinic: Klinik Pakar Kulit Ranjit C4, Jalan SS15/4D , 47500 Subang Jaya, Selangor Darul Ehsan, Malaysia. Ranjit Skin Specialist Reviews: Dr Ko vs Dr Ranjit https://forum.lowyat.net/topic/4374192/all Any recommendation for a good Skin Specialist around SJ? http://www.usj.com.my/bulletin Skin disease doctor - USJ-Subang Jaya e-community May 24, 2012 - 8 posts - 7 authors But be prepared to wait for longggggg Q since Dr Ting also a very very popular Skin Specialist in KL. Best is to make an appointment to find out ... Facial surgery - USJ-Subang Jaya e-community Feb 20, 2010 - 15 posts - 9 authors I saw someone who used some prescribed cream from a skin specialist but didnt follow proper instructions and ended up with more dark ... Decent Pakar Kulit in USJ - USJ-Subang Jaya e-community Sep 19, 2007 - 11 posts - 9 authors Ranjit Skin clinic
If you are looking for the best and recommended hair loss treatment centres in Malaysia , you are in the right place. “Hair loss treatment Malaysia” is one of the most Googled aesthetic clinic related terms locally. Many at times, most patients visit a doctor only after they have tried many ineffective hair loss treatments. With so much misinformation out there, we are compelled to clear up the misinformation and compose this hair loss treatment guide for the public. There are many causes for hair loss in both men and women. The first step in solving your hair loss problem is to find out the 'cause' of your hair loss. The cause of your hair loss will need to be determined before you consider the hair loss treatment solution that is right and effective for you. A hair loss treatment solution is not a one size fits all solution. Most hair loss centres in Malaysia have over-simplified solutions and do not dig deep enough to your problem. You may have a medical problem or you could
VitaminDforAll.org - In an open letter being sent to world governments on the 21st December, 2020; 120 health, science and medical experts from the UK, US and Europe said there is clear scientific evidence that vitamin D reduces COVID-19 infections, hospitalisations and deaths. The Letter To all governments, public health officials, doctors, and healthcare workers, Research shows low vitamin D levels almost certainly promote COVID-19 infections, hospitalizations, and deaths. Given its safety, w e call for immediate widespread increased vitamin D intakes . Vitamin D modulates thousands of genes and many aspects of immune function, both innate and adaptive. The scientific evidence 1 shows that: Higher vitamin D blood levels are associated with lower rates of SARS-CoV-2 infection. Higher D levels are associated with lower risk of a severe case (hospitalization, ICU, or death). Intervention studies (including RCTs) indicate that vitamin D can be a very effective treatment. Many pape
How many times have you tried Googling and asking your friends for recommended acne skincare products, but found yourself confused and overwhelmed? If you are looking for the best acne treatment product in Malaysia , you are in the right place. This article was written with you in mind. Pimples form when dead skin cells mix with excess oil (sebum). This mixture plugs the pore, causing swelling. Bacteria can grow in the mix and lead to infection and pus. In order to treat acne, dead skin cells need to be cleared and oil-polluted pores need to be unclogged as well. The secret? ... Benzoyl Peroxide. When applied to the skin, benzoyl peroxide works by reducing the amount of acne-causing bacteria and also by causing the skin to dry and peel; therefore unclogging the infected oil-polluted pores as well. Benzoyl peroxide for acne treatment is typically applied to the affected areas in gel or cream form, in concentrations of 2.5% increasing through 5.0%, and up to 10%.No strong evide
As of January 2021, there are more than 4,300 studies that have been launched to investigate various treatments for COVID-19. You can review the details of these trials on ClinicalTrials.gov . New ones are being added every day. Below, we look at the top 10 most tested categories. 1. Vaccine This is the most watched and anticipated category. Technically, vaccine is not considered to be a treatment but rather a preventive strategy to reduce the risk of getting COVID-19. As of January 2021, there are more than 170 on-going trials in various phases. The vaccine remains a promising agent for COVID-19 protection, and the published reports of the candidate vaccines showcase some encouraging results. Major vaccine candidates: Pfizer/BioNTech COVID-19 mRNA vaccine - This is the first vaccine to receive WHO validation for emergency use. Oxford - AstraZeneca (inactivated vaccine) Moderna (mRNA vaccine) SinoVac Biotech inactivated vaccine (Beijing-based biopharmaceutical company Sinovac is be
Dec. 31, 2020 /PRNewswire/ -- A peer-reviewed updated summary of COVID-19 early-treatment best practices was published in Reviews in Cardiovascular Medicine , an interdisciplinary scientific, open access journal. This international collaboration — comprised of physicians, like lead author Peter McCullough , MD, outlines the urgency of "prompt early initiation of sequenced multi-drug therapy (SMDT) … to stem the tide of hospitalizations and death." The authors explain: The early stage of viral replication provides a therapeutic window of tremendous opportunity to potentially reduce the risk of more severe sequelae in high risk patients. Precious time is squandered with a 'wait and see' approach … resulting in unnecessary hospitalization, morbidity, and death.… In newly diagnosed, high-risk, symptomatic patients with COVID-19, SMDT has a reasonable chance of therapeutic gain with an acceptable benefit-to-risk profile. Included in the paper is a "sequential multi
Whether homemade or commercially manufactured, breathable cloth and disposable face masks fit everybody differently, leaving gaps at the top, sides, bottom — or any combination thereof — that could allow virus particles to escape. Now, a team of University of Wisconsin–Madison engineers has developed a simple and inexpensive do-it-yourself fitter that ensures a tighter mask seal around the wearer’s nose, mouth and face. Known as the Badger Seal , the mask fitter is a soft, adjustable “frame” with elastic worn either as ear loops or behind the head. With readily available materials, such as elastic cord, foam wire or pipe cleaners, the fitter is easy to make at home in minutes. When worn over non-medical-grade disposable masks, the Badger Seal significantly improves the masks’ filtration performance, according to research conducted by Scott Sanders and David Rothamer, UW–Madison professors of mechanical engineering and experts in measuring gases and particles in internal combustion eng
It's December 2020 and it has been more than 6 months since the World Health Organisation announced COVID-19 outbreak a pandemic in March 2020. As time passes in a pandemic, new evidence has emerged and there are things about supplements that we know now that we didn't know in March 2020. 'Supplements and COVID-19' is a controversial subject. On one side are experts telling you that supplements don't work and you should avoid them and just rely on wholesome foods. On the other, are experts telling you to take all kinds of supplements that will help protect you against COVID-19. Do they actually work? Some supplements do have evidence and some don't. This guide can help you make sense of the options and to separate the facts from fiction. 'Supplements and COVID-19' is not a static science and is highly dynamic. Therefore, this article is a work-in-progress article as new evidence might be added from time to time. We will list the top 10 supplements that