6 Best IP6 Supplements of 2023

Inositol hexaphosphate (IP6), a polyphosphorylated carbohydrate is a naturally occurring compound that abundantly present in most plants, mammalian cells, and in certain high-fiber diets, such as cereals and legumes. Moreover, IP6 is marketed as a supplement.

IP(6) has long been acknowledged as a natural antioxidant. Recently, IP(6) has drawn a lot of attention for its function in controlling experimental tumor growth, progression, and metastasis as well as in the prevention of cancer.

IP6 Benefits

IP6 are known for supporting and restoring immune system. It was also discovered that IP6 increased the activity of natural killer (NK).

IP6 for Cancer Prevention and Therapy
A striking anticancer action of IP(6) was demonstrated in different experimental models. In addition to reducing cell proliferation, IP(6) also induces differentiation of malignant cells. Enhanced immunity and antioxidant properties also contribute to tumor cell destruction.

Preliminary studies in humans show that IP(6) and inositol, the precursor molecule of IP(6), appear to enhance the anticancer effect of conventional chemotherapy, control cancer metastases, and improve quality of life.

IP6 for Kidney Stone Prevention
IP-6 reduces urinary calcium levels and may reduce the risk of forming a kidney stone. In one trial, 120 mg per day of IP-6 for 15 days significantly reduced the formation of calcium oxalate crystals in the urine of people with a history of kidney stone formation.

IP6 Supplements for Treating Diabetes Mellitus
The hypoglycemic activity of inositols by way of IP6 and inositol supplements may partly be due to intestinal weight reduction that results in the alteration of the activities of some enzymes involved in carbohydrate digestion. Hence, the consumption of these supplements may step down intestinal carbohydrate digestion, which in turn leads to reduced blood glucose levels.

Moreover, supplementation with IP6 and lower inositols may be beneficial in the prevention of diabetic complications since it reverses the diabetes-induced down regulation of the antioxidant defense system.

Best IP6 Supplements 

1. Nature's Way Cell Forté IP-6 & Inositol Supplement

IP-6 is found in rice bran and other foods, while inositol is a type of sugar that is a component of cell membranes. IP-6 is often lacking in foods that have been processed since IP-6 is usually found in the bran or hull, which is often milled away.

This IP6 supplement is gluten-free and vegan. No yeast-derived ingredients, wheat, soy, dairy, or artificial colors, flavors, or preservatives.

Calcium (from calcium magnesium phytate); Phosphorus (from calcium magnesium phytate); Magnesium (from calcium magnesium phytate); IP-6 (inositol hexaphosphate) (from calcium magnesium phytate); Inositol; Cellulose; Plant-Derived Capsule (Hypromellose); Magnesium Stearate

4.7 out of 5 - more than 1,300 global ratings

I began taking this supplement about 9 years ago. I started taking it to increase my immune system, so I wouldn’t get sick often. It seemed to really make a difference. But the reason I would not want to stop taking it, ever, is because soon after I had been using it, I realized that my skin was looking much better, and this has continued. (Before I started taking it, I was seeing a lot of brown spots appearing. I’m 69 years old.) And I take only two each morning, on an empty stomach, so the bottle of 240 capsules is very economical, really. I recommend this product, for sure!

2. IP6 Gold Immune Support Formula

- Trusted Sourcing
IP6 Gold is the IP6 supplement you can trust. IP6 Gold is made from the purest grade of IP6 (Inositol Hexaphosphate) & Inositol (as Myo-Inositol) available from Japan. Many companies source IP6 & Inositol from China so buyer beware! IP6 Gold is the only IP6 product certified non-GMO by the Non-GMO Project Verified.

- Gold Standard
To achieve our Gold Standard level, we third-party test raw materials to exacting guidelines ensuring a safe, pure, and potent product. In fact, IP6 Gold is so revered that it has been used in published scientific research.

- Pure, Simple Ingredients
IP6 Gold capsules are manufactured without unnecessary excipients such as magnesium stearate, silicon dioxide or gelatin capsules.

- Safely Made
IP6 Gold is manufactured in the United States to strict Good Manufacturing Practices (cGMP).

- Dynamic Duo
IP6 Gold is a dynamic duo of IP6 and Inositol derived from non-GMO rice bran. IP6 & Myo Inositol are recognized as powerful antioxidants that have the ability to neutralize multiple oxidants at the same time providing a profound effect on immune function, glucose metabolism, kidney, cardiovascular, brain health and more!

4.6 out of 5 - more than 600 global ratings

This product was originally "prescribed" for me by a practitioner of Chinese medicine as an immune booster. It helped the reason it was prescribed for and I have taken it for many, many years (going off it occasionally for a week or two at a time). I believe that building your immune system definitely helps keep one from contracting viruses. Can't remember the last time I had a cold!

3. Best Naturals IP-6 510 mg 

- 3rd party lab tested for purity & quality.
- non-GMO & gluten-free.
- proudly made in usa, gmp compliant, FDA registered facility.
- no artificial color, flavor, or sweetener, no preservatives, no sugar, no milk, no corn, no soy, no egg, no lactose, no gluten, no wheat, no yeast, no fish. Sodium free.

The most important thing I like...... Is that IP-6 is an excellent "cancer prevention" supplement !!
I take it 5 nights a week before bedtime ( along with some Chlorophyll ) to help my body kill-off
most of the cancer cells that need to be removed, while I am sleeping.
Also, there are ( 180 ) capsules in the bottle, so that's a pretty good deal.

4. Pure Encapsulations IP6 Supplement

- Antioxidant Support
IP6 is a natural antioxidant component of fiber-rich foods and is found in almost every cell in the body.*

- Cellular Health
IP6 promotes healthy cell metabolism and helps maintain proper enzyme activity in cells.*

- Antioxidant Defense Support
The unique conformation of IP6 also gives it the specific ability to modulate hydroxyl radical formation, supporting natural defense mechanisms.*

- Pure Quality
Our supplements are made with only premium ingredients sourced from trusted suppliers and guided by our nutritional experts, then carefully manufactured and tested to verify their potency and purity.

- Pure Difference
What makes us different isn't just our process or what goes into our supplements -- what we leave out matters, too. Pure Encapsulations products are FREE FROM wheat, eggs, tree nuts & peanuts, gluten, artificial colors, flavors & sweeteners, coatings and shellacs, GMOs, and unnecessary binders, fillers & preservatives.

I had been taking an other Manufacturer's IP-6 and ran out. They did not have it in stock so to Amazon I went.
I found these guys and I will never switch back! Vegetarian capsule and ZERO additives. All at a great price!
You will not feel a whole lot different but was with most supplements they have a long term effect, IP-6 is one of those while you may not feel a whole different, your body will appreciate it years down the line.

5. BulkSupplements.com IP6 Powder

- source of antioxidants 
- maintains liver health
- supports neurotransmitter production

- Pure and Clean Supplement 
Our Inositol Hexaphosphate, which is also an inositol powder, is pure and clean without any fillers, additives, and artificial flavors. Not only that it's filler free, this Inositol supplement, an immune support supplement, is dairy free, soy free, gluten free and especially no added sugars.

- High Quality  
All products by BulkSupplements are manufactured according to cGMP Standards to ensure the highest quality for manufacturing, packaging, labeling, and holding operations. We’ve made a significant investment in our in-house lab so we can test our products at multiple stages during production. We third party test products, procedures and equipment when required to ensure compliance, standards and consistency.

I am on a number of supplements for my alternative cancer treatment protocol. I like the quality I receive from this provider. As with most supplements you do need to get accustomed to the taste but I mix this with carrot juice and it's fine. Love this provider. Also purchased MSM. They offer multiple size options for greater savings which is wonderful when you are multiple supplements the cost does get expensive.. Great products, great pricing fast shipping. Can't ask for more.

6. Source Naturals IP-6 Powder 

- powerful antioxidant supports cardiovascular and immune system health
- 2,400 mg of ip-6 per serving
- suitable for vegetarians
- gluten free, vegetarian

Quick shipping! Pricey, but worth the price if it helps my health.


a. Who Should Not Take IP6 Supplement?

- People who consume mineral supplements. Phytic acid can bind with calcium, iron, magnesium, and zinc and lessen their bioavailability.

- People who take anticoagulants/antiplatelets. IP6 also can slow blood clotting and may increase bleeding risk.

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