The Medical Advisor

Introduction: Exploring Fenbendazole as a Potential Treatment for Stage 4 Pancreatic Cancer Pancreatic cancer  is among the most aggressive and difficult cancers to treat, particularly in its later stages. Approaches to improve pancreatic cancer therapy are essential as this disease has a very bleak outcome. Approximately 80% of pancreatic cancers are pancreatic ductal adenocarcinomas (PDAC). PDAC is a cancer which is difficult to effectively treat as it is often detected late in the disease process. Almost all PDACs (over 90%) have activating mutations in the  GTPase  gene  KRAS . Pancreatic cancer has a high mortality rate and is often resistant to conventional treatments. Standard therapeutic options include surgical resection, chemotherapy, and radiation therapy, yet survival rates remain low. Recently, alternative treatment strategies have gained interest, including the repurposing of existing drugs originally developed for non-cancer indications.  Given th...