IVERMECTIN Solution vs Pills vs Capsules: Study

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Ivermectin Solution vs Pills vs Capsules: What's the Difference?

In 2023, a research team in Argentina led by Ceballos et al. analyzed systemic availability and disposition kinetics of Ivermectin orally administered as different pharmaceutical formulations (tablet, solution, or capsule) to healthy adults. Volunteers were randomly assigned to 1 of 3 experimental groups and orally treated with IVM as either, a tablet, solution, or capsules at 0.4 mg/kg Blood samples were taken as dried blood spots (DBS) between 2 and 48 h post-treatment and IVM was analyzed by HPLC with fluorescence detection .

IVERMECTIN Solution vs Pills vs Capsules

Conclusion: 
  • Liquid Ivermectin gives 68% higher peak blood level than tablet (120.4 vs 71.8) 
  • Liquid Ivermectin gives 56% higher systemic availability than tablet (1653 vs 1056) 
  • Women reach 76% higher peak blood level with Liquid Ivermectin than men (153.7 vs 87.1) 
  • Women get 27% more systemic availability from Liquid Ivermectin than men

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